Quantifying Delivered Dose with Jet and Mesh Nebulizers during Spontaneous Breathing, Noninvasive Ventilation, and Mechanical Ventilation in a Simulated Pediatric Lung Model with Exhaled Humidity
Acutely ill children may transition between spontaneous breathing (SB), noninvasive ventilation (NIV), and mechanical ventilation (MV), and commonly receive the same drug dosage with each type of ventilatory support and interface. This study aims to determine the aerosol deposition with jet (JN) and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/8/1179 |
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| author | Arzu Ari James B. Fink |
| author_facet | Arzu Ari James B. Fink |
| author_sort | Arzu Ari |
| collection | DOAJ |
| description | Acutely ill children may transition between spontaneous breathing (SB), noninvasive ventilation (NIV), and mechanical ventilation (MV), and commonly receive the same drug dosage with each type of ventilatory support and interface. This study aims to determine the aerosol deposition with jet (JN) and mesh nebulizers (MN) during SB, NIV, and MV using a pediatric lung model. Drug delivery with JN (Mistymax10) and MN (Aerogen Solo) was compared during SB, NIV, and MV using three different lung models set to simulate the same breathing parameters (Vt 250 mL, RR 20 bpm, I:E ratio 1:3). A heated humidifier was placed between the filter and test lung to simulate exhaled humidity (35 ± 2 °C, 100% RH) with all lung models. Albuterol sulfate (2.5 mg/3 mL) was delivered, and the drug deposited on an absolute filter was eluted and analyzed with spectrophotometry. Aerosol delivery with JN was not significantly different during MV, NIV, and SB (<i>p</i> = 0.075), while inhaled dose obtained with MN during MV was greater than NIV and SB (<i>p</i> = 0.001). The delivery efficiency of MN was up to 3-fold more than JN during MV (<i>p</i> = 0.008), NIV (<i>p</i> = 0.005), and SB (<i>p</i> = 0.009). Delivered dose with JN was similar during MV, NIV, and SB, although the delivery efficiency of MN differs with different modes of ventilation. |
| first_indexed | 2024-03-10T08:29:17Z |
| format | Article |
| id | doaj.art-67110dc933424739a7019bab4147bce9 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T08:29:17Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-67110dc933424739a7019bab4147bce92023-11-22T09:13:49ZengMDPI AGPharmaceutics1999-49232021-07-01138117910.3390/pharmaceutics13081179Quantifying Delivered Dose with Jet and Mesh Nebulizers during Spontaneous Breathing, Noninvasive Ventilation, and Mechanical Ventilation in a Simulated Pediatric Lung Model with Exhaled HumidityArzu Ari0James B. Fink1Department of Respiratory Care, College of Health Profession, Texas State University, Round Rock, TX 78665, USADepartment of Respiratory Care, College of Health Profession, Texas State University, Round Rock, TX 78665, USAAcutely ill children may transition between spontaneous breathing (SB), noninvasive ventilation (NIV), and mechanical ventilation (MV), and commonly receive the same drug dosage with each type of ventilatory support and interface. This study aims to determine the aerosol deposition with jet (JN) and mesh nebulizers (MN) during SB, NIV, and MV using a pediatric lung model. Drug delivery with JN (Mistymax10) and MN (Aerogen Solo) was compared during SB, NIV, and MV using three different lung models set to simulate the same breathing parameters (Vt 250 mL, RR 20 bpm, I:E ratio 1:3). A heated humidifier was placed between the filter and test lung to simulate exhaled humidity (35 ± 2 °C, 100% RH) with all lung models. Albuterol sulfate (2.5 mg/3 mL) was delivered, and the drug deposited on an absolute filter was eluted and analyzed with spectrophotometry. Aerosol delivery with JN was not significantly different during MV, NIV, and SB (<i>p</i> = 0.075), while inhaled dose obtained with MN during MV was greater than NIV and SB (<i>p</i> = 0.001). The delivery efficiency of MN was up to 3-fold more than JN during MV (<i>p</i> = 0.008), NIV (<i>p</i> = 0.005), and SB (<i>p</i> = 0.009). Delivered dose with JN was similar during MV, NIV, and SB, although the delivery efficiency of MN differs with different modes of ventilation.https://www.mdpi.com/1999-4923/13/8/1179aerosolsdrug deliverydrug dosagenebulizerschildren |
| spellingShingle | Arzu Ari James B. Fink Quantifying Delivered Dose with Jet and Mesh Nebulizers during Spontaneous Breathing, Noninvasive Ventilation, and Mechanical Ventilation in a Simulated Pediatric Lung Model with Exhaled Humidity Pharmaceutics aerosols drug delivery drug dosage nebulizers children |
| title | Quantifying Delivered Dose with Jet and Mesh Nebulizers during Spontaneous Breathing, Noninvasive Ventilation, and Mechanical Ventilation in a Simulated Pediatric Lung Model with Exhaled Humidity |
| title_full | Quantifying Delivered Dose with Jet and Mesh Nebulizers during Spontaneous Breathing, Noninvasive Ventilation, and Mechanical Ventilation in a Simulated Pediatric Lung Model with Exhaled Humidity |
| title_fullStr | Quantifying Delivered Dose with Jet and Mesh Nebulizers during Spontaneous Breathing, Noninvasive Ventilation, and Mechanical Ventilation in a Simulated Pediatric Lung Model with Exhaled Humidity |
| title_full_unstemmed | Quantifying Delivered Dose with Jet and Mesh Nebulizers during Spontaneous Breathing, Noninvasive Ventilation, and Mechanical Ventilation in a Simulated Pediatric Lung Model with Exhaled Humidity |
| title_short | Quantifying Delivered Dose with Jet and Mesh Nebulizers during Spontaneous Breathing, Noninvasive Ventilation, and Mechanical Ventilation in a Simulated Pediatric Lung Model with Exhaled Humidity |
| title_sort | quantifying delivered dose with jet and mesh nebulizers during spontaneous breathing noninvasive ventilation and mechanical ventilation in a simulated pediatric lung model with exhaled humidity |
| topic | aerosols drug delivery drug dosage nebulizers children |
| url | https://www.mdpi.com/1999-4923/13/8/1179 |
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