Role of Nano-miRNAs in Diagnostics and Therapeutics
MicroRNAs (miRNA) are key regulators of gene expression, controlling different biological processes such as cellular development, differentiation, proliferation, metabolism, and apoptosis. The relationships between miRNA expression and the onset and progression of different diseases, such as tumours...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/12/6836 |
| _version_ | 1797486364558622720 |
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| author | Donatella Coradduzza Emanuela Bellu Antonella Congiargiu Aleksei Pashchenko Evzen Amler Alois Necas Ciriaco Carru Serenella Medici Margherita Maioli |
| author_facet | Donatella Coradduzza Emanuela Bellu Antonella Congiargiu Aleksei Pashchenko Evzen Amler Alois Necas Ciriaco Carru Serenella Medici Margherita Maioli |
| author_sort | Donatella Coradduzza |
| collection | DOAJ |
| description | MicroRNAs (miRNA) are key regulators of gene expression, controlling different biological processes such as cellular development, differentiation, proliferation, metabolism, and apoptosis. The relationships between miRNA expression and the onset and progression of different diseases, such as tumours, cardiovascular and rheumatic diseases, and neurological disorders, are well known. A nanotechnology-based approach could match miRNA delivery and detection to move beyond the proof-of-concept stage. Different kinds of nanotechnologies can have a major impact on the diagnosis and treatment of miRNA-related diseases such as cancer. Developing novel methodologies aimed at clinical practice represents a big challenge for the early diagnosis of specific diseases. Within this context, nanotechnology represents a wide emerging area at the forefront of research over the last two decades, whose potential has yet to be fully attained. Nanomedicine, derived from nanotechnology, can exploit the unique properties of nanometer-sized particles for diagnostic and therapeutic purposes. Through nanomedicine, specific treatment to counteract only cancer-cell proliferation will be improved, while leaving healthy cells intact. In this review, we dissect the properties of different nanocarriers and their roles in the early detection and treatment of cancer. |
| first_indexed | 2024-03-09T23:32:09Z |
| format | Article |
| id | doaj.art-67153f3c9eec4015bb83fe64d498c5c6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:32:09Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-67153f3c9eec4015bb83fe64d498c5c62023-11-23T17:07:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012312683610.3390/ijms23126836Role of Nano-miRNAs in Diagnostics and TherapeuticsDonatella Coradduzza0Emanuela Bellu1Antonella Congiargiu2Aleksei Pashchenko3Evzen Amler4Alois Necas5Ciriaco Carru6Serenella Medici7Margherita Maioli8Department of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyInstitute of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague, Czech RepublicFaculty of Veterinary Medicine, University of Veterinary and Sciences Brno, Palackeho tr. 1946/1, 612 42 Brno, Czech RepublicDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Chemistry and Pharmacy, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyMicroRNAs (miRNA) are key regulators of gene expression, controlling different biological processes such as cellular development, differentiation, proliferation, metabolism, and apoptosis. The relationships between miRNA expression and the onset and progression of different diseases, such as tumours, cardiovascular and rheumatic diseases, and neurological disorders, are well known. A nanotechnology-based approach could match miRNA delivery and detection to move beyond the proof-of-concept stage. Different kinds of nanotechnologies can have a major impact on the diagnosis and treatment of miRNA-related diseases such as cancer. Developing novel methodologies aimed at clinical practice represents a big challenge for the early diagnosis of specific diseases. Within this context, nanotechnology represents a wide emerging area at the forefront of research over the last two decades, whose potential has yet to be fully attained. Nanomedicine, derived from nanotechnology, can exploit the unique properties of nanometer-sized particles for diagnostic and therapeutic purposes. Through nanomedicine, specific treatment to counteract only cancer-cell proliferation will be improved, while leaving healthy cells intact. In this review, we dissect the properties of different nanocarriers and their roles in the early detection and treatment of cancer.https://www.mdpi.com/1422-0067/23/12/6836nano–microRNAnanotechnology biomarkertarget therapy |
| spellingShingle | Donatella Coradduzza Emanuela Bellu Antonella Congiargiu Aleksei Pashchenko Evzen Amler Alois Necas Ciriaco Carru Serenella Medici Margherita Maioli Role of Nano-miRNAs in Diagnostics and Therapeutics International Journal of Molecular Sciences nano–microRNA nanotechnology biomarker target therapy |
| title | Role of Nano-miRNAs in Diagnostics and Therapeutics |
| title_full | Role of Nano-miRNAs in Diagnostics and Therapeutics |
| title_fullStr | Role of Nano-miRNAs in Diagnostics and Therapeutics |
| title_full_unstemmed | Role of Nano-miRNAs in Diagnostics and Therapeutics |
| title_short | Role of Nano-miRNAs in Diagnostics and Therapeutics |
| title_sort | role of nano mirnas in diagnostics and therapeutics |
| topic | nano–microRNA nanotechnology biomarker target therapy |
| url | https://www.mdpi.com/1422-0067/23/12/6836 |
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