Composite Polyurethane-Polylactide (PUR/PLA) Flexible Filaments for 3D Fused Filament Fabrication (FFF) of Antibacterial Wound Dressings for Skin Regeneration
This paper addresses the potential application of flexible thermoplastic polyurethane (TPU) and poly(lactic acid) (PLA) compositions as a material for the production of antibacterial wound dressings using the Fused Filament Fabrication (FFF) 3D printing method. On the market, there are medical-grade...
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2021-10-01
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| Online Access: | https://www.mdpi.com/1996-1944/14/20/6054 |
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| author | Paweł Szarlej Iga Carayon Przemysław Gnatowski Marta Glinka Martyna Mroczyńska Anna Brillowska-Dąbrowska Justyna Kucińska-Lipka |
| author_facet | Paweł Szarlej Iga Carayon Przemysław Gnatowski Marta Glinka Martyna Mroczyńska Anna Brillowska-Dąbrowska Justyna Kucińska-Lipka |
| author_sort | Paweł Szarlej |
| collection | DOAJ |
| description | This paper addresses the potential application of flexible thermoplastic polyurethane (TPU) and poly(lactic acid) (PLA) compositions as a material for the production of antibacterial wound dressings using the Fused Filament Fabrication (FFF) 3D printing method. On the market, there are medical-grade polyurethane filaments available, but few of them have properties required for the fabrication of wound dressings, such as flexibility and antibacterial effects. Thus, research aimed at the production, characterization and modification of filaments based on different TPU/PLA compositions was conducted. The combination of mechanical (tensile, hardness), structural (FTIR), microscopic (optical and SEM), degradation (2 M HCl, 5 M NaOH, and 0.1 M CoCl<sub>2</sub> in 20% H<sub>2</sub>O<sub>2</sub>) and printability analysis allowed us to select the most promising composition for further antibacterial modification (COMP-7,5PLA). The thermal stability of the chosen antibiotic—amikacin—was tested using processing temperature and HPLC. Two routes were used for the antibacterial modification of the selected filament—post-processing modification (AMI-1) and modification during processing (AMI-2). The antibacterial activity and amikacin release profiles were studied. The postprocessing modification method turned out to be superior and suitable for wound dressing fabrication due to its proven antimicrobial activity against <i>E. coli</i>, <i>P. fluorescens</i>, <i>S. aureus</i> and <i>S. epidermidis</i> bacteria. |
| first_indexed | 2024-03-10T06:25:58Z |
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| id | doaj.art-671662d161cd4f0e85f5b061919465b6 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T06:25:58Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-671662d161cd4f0e85f5b061919465b62023-11-22T18:58:17ZengMDPI AGMaterials1996-19442021-10-011420605410.3390/ma14206054Composite Polyurethane-Polylactide (PUR/PLA) Flexible Filaments for 3D Fused Filament Fabrication (FFF) of Antibacterial Wound Dressings for Skin RegenerationPaweł Szarlej0Iga Carayon1Przemysław Gnatowski2Marta Glinka3Martyna Mroczyńska4Anna Brillowska-Dąbrowska5Justyna Kucińska-Lipka6Faculty of Chemistry, Department of Polymer Technology, Gdansk University of Technology, 80-233 Gdansk, PolandFaculty of Chemistry, Department of Polymer Technology, Gdansk University of Technology, 80-233 Gdansk, PolandFaculty of Chemistry, Department of Polymer Technology, Gdansk University of Technology, 80-233 Gdansk, PolandFaculty of Chemistry, Department of Analytical Chemistry, Gdansk University of Technology, 80-233 Gdansk, PolandFaculty of Chemistry, Department of Molecular Biotechnology and Microbiology, Gdansk University of Technology, 80-233 Gdansk, PolandFaculty of Chemistry, Department of Molecular Biotechnology and Microbiology, Gdansk University of Technology, 80-233 Gdansk, PolandFaculty of Chemistry, Department of Polymer Technology, Gdansk University of Technology, 80-233 Gdansk, PolandThis paper addresses the potential application of flexible thermoplastic polyurethane (TPU) and poly(lactic acid) (PLA) compositions as a material for the production of antibacterial wound dressings using the Fused Filament Fabrication (FFF) 3D printing method. On the market, there are medical-grade polyurethane filaments available, but few of them have properties required for the fabrication of wound dressings, such as flexibility and antibacterial effects. Thus, research aimed at the production, characterization and modification of filaments based on different TPU/PLA compositions was conducted. The combination of mechanical (tensile, hardness), structural (FTIR), microscopic (optical and SEM), degradation (2 M HCl, 5 M NaOH, and 0.1 M CoCl<sub>2</sub> in 20% H<sub>2</sub>O<sub>2</sub>) and printability analysis allowed us to select the most promising composition for further antibacterial modification (COMP-7,5PLA). The thermal stability of the chosen antibiotic—amikacin—was tested using processing temperature and HPLC. Two routes were used for the antibacterial modification of the selected filament—post-processing modification (AMI-1) and modification during processing (AMI-2). The antibacterial activity and amikacin release profiles were studied. The postprocessing modification method turned out to be superior and suitable for wound dressing fabrication due to its proven antimicrobial activity against <i>E. coli</i>, <i>P. fluorescens</i>, <i>S. aureus</i> and <i>S. epidermidis</i> bacteria.https://www.mdpi.com/1996-1944/14/20/6054compositepolyurethanepoly(lactic acid)3D printingskin engineeringamikacin sulfate |
| spellingShingle | Paweł Szarlej Iga Carayon Przemysław Gnatowski Marta Glinka Martyna Mroczyńska Anna Brillowska-Dąbrowska Justyna Kucińska-Lipka Composite Polyurethane-Polylactide (PUR/PLA) Flexible Filaments for 3D Fused Filament Fabrication (FFF) of Antibacterial Wound Dressings for Skin Regeneration Materials composite polyurethane poly(lactic acid) 3D printing skin engineering amikacin sulfate |
| title | Composite Polyurethane-Polylactide (PUR/PLA) Flexible Filaments for 3D Fused Filament Fabrication (FFF) of Antibacterial Wound Dressings for Skin Regeneration |
| title_full | Composite Polyurethane-Polylactide (PUR/PLA) Flexible Filaments for 3D Fused Filament Fabrication (FFF) of Antibacterial Wound Dressings for Skin Regeneration |
| title_fullStr | Composite Polyurethane-Polylactide (PUR/PLA) Flexible Filaments for 3D Fused Filament Fabrication (FFF) of Antibacterial Wound Dressings for Skin Regeneration |
| title_full_unstemmed | Composite Polyurethane-Polylactide (PUR/PLA) Flexible Filaments for 3D Fused Filament Fabrication (FFF) of Antibacterial Wound Dressings for Skin Regeneration |
| title_short | Composite Polyurethane-Polylactide (PUR/PLA) Flexible Filaments for 3D Fused Filament Fabrication (FFF) of Antibacterial Wound Dressings for Skin Regeneration |
| title_sort | composite polyurethane polylactide pur pla flexible filaments for 3d fused filament fabrication fff of antibacterial wound dressings for skin regeneration |
| topic | composite polyurethane poly(lactic acid) 3D printing skin engineering amikacin sulfate |
| url | https://www.mdpi.com/1996-1944/14/20/6054 |
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