Adult T-cell leukemia and lymphoma in French Guiana: a retrospective analysis with real-life data from 2009 to 2019Research in context
Summary: Background: Adult T-cell leukemia/lymphoma (ATL), one of the most aggressive cancers in the world, occurs in 5% of the 10 million people living with HTLV-1 worldwide. French Guiana, a French overseas territory in South America, is one of the highest endemic areas of HTLV-1 worldwide. Here,...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | The Lancet Regional Health. Americas |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667193X23000662 |
| _version_ | 1827962578276450304 |
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| author | Karim Abdelmoumen Kinan Drak Alsibai Sébastien Rabier Mathieu Nacher N'detodji-Bill Wankpo Antoine Gessain Florin Santa Olivier Hermine Ambroise Marçais Pierre Couppié Jean-Pierre Droz Loïc Epelboin |
| author_facet | Karim Abdelmoumen Kinan Drak Alsibai Sébastien Rabier Mathieu Nacher N'detodji-Bill Wankpo Antoine Gessain Florin Santa Olivier Hermine Ambroise Marçais Pierre Couppié Jean-Pierre Droz Loïc Epelboin |
| author_sort | Karim Abdelmoumen |
| collection | DOAJ |
| description | Summary: Background: Adult T-cell leukemia/lymphoma (ATL), one of the most aggressive cancers in the world, occurs in 5% of the 10 million people living with HTLV-1 worldwide. French Guiana, a French overseas territory in South America, is one of the highest endemic areas of HTLV-1 worldwide. Here, we describe the demographic and clinical characteristics and outcome of ATL in this area. Methods: We retrospectively collected data from all patients diagnosed between 2009 and 2019. Patients were distributed according to Shimoyama's classification. Prognostic factors were explored through univariate analysis. Findings: Over the 10-year study period, 41 patients with a median age of 54 years at diagnosis were identified, among whom 56% were women. Sixteen (39%) patients were Maroons, a cultural group descendant of the runaway enslaved Africans from former Dutch Guiana. Among the study population, 23 (56%) had an acute type, 14 (34%) a lymphoma type, and one and one chronic and primary cutaneous tumour, respectively. First-lines of treatment included either chemotherapy or Zidovudine combined with pegylated interferon alpha. The 4-year overall survival was 11.4% for the entire population with 0% and 11% for lymphoma and acute forms, respectively. The median progression-free survival was 93 and 115 days for the acute and lymphoma groups (p = 0.37), respectively. Among the twenty-nine patients who died, 8 (28%) died of toxicity, 7 (24%) died of disease progression and the cause of death remained unknown in 14 (48%) patients. Due to the overall poor prognosis, no significant prognostic factors could be identified. Interpretation: This study provides real-life data from ATL patients in French Guiana, a remote territory in a middle-income region. Patients, mostly Maroons, presented with a younger age and the prognosis was worse than expected compared to Japanese patients. Funding: None. |
| first_indexed | 2024-04-09T16:44:43Z |
| format | Article |
| id | doaj.art-67195c0b2b5a4bf2963c7f1b04641e87 |
| institution | Directory Open Access Journal |
| issn | 2667-193X |
| language | English |
| last_indexed | 2024-04-09T16:44:43Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Americas |
| spelling | doaj.art-67195c0b2b5a4bf2963c7f1b04641e872023-04-23T06:07:58ZengElsevierThe Lancet Regional Health. Americas2667-193X2023-05-0121100492Adult T-cell leukemia and lymphoma in French Guiana: a retrospective analysis with real-life data from 2009 to 2019Research in contextKarim Abdelmoumen0Kinan Drak Alsibai1Sébastien Rabier2Mathieu Nacher3N'detodji-Bill Wankpo4Antoine Gessain5Florin Santa6Olivier Hermine7Ambroise Marçais8Pierre Couppié9Jean-Pierre Droz10Loïc Epelboin11Department of Internal Medicine, University of la Réunion, Reunion Island, France; Department of Dermatology, Cayenne Hospital, French Guiana, France; Corresponding author. Université de La Réunion, département de médecine interne, Site du Tampon-Campus Sud, 117 Rue du Général Ailleret, 97430 Le Tampon, La Réunion; Unité des Maladies infectieuses et tropicales, CH de Cayenne Andrée Rosemon, 97300, French Guiana, France.Department of Pathology, Cayenne Hospital, French Guiana, FranceCorevih Guyane, Cayenne Hospital, French Guiana, FranceCentre d’Investigation Clinique Antilles Guyane – CIC Inserm 1424, Centre Hospitalier de Cayenne Andrée Rosemon, and French Guiana University, French Guiana, FranceOncology Program, Centre Hospitalier de l’Ouest-Guyane, Saint-Laurent du Maroni, French Guiana, FranceEpidemiology and Physiopathology of Oncogenic Viruses, Pasteur Institute, Paris, FranceDepartment of Oncology, Cayenne Hospital, French Guiana, FranceDepartment of Hematology, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, INSERM UMR 1163 et CNRS ERL 8254, Institut Imagine, Université Paris Cité, Paris, FranceDepartment of Hematology, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, INSERM UMR 1151 and CNRS, Institut Necker, Université Paris Cité, Paris, FranceDepartment of Dermatology, Cayenne Hospital, French Guiana, FranceDepartment of Medical Oncology, Centre Léon-Bérard, Lyon, France; Claude-Bernard Lyon University, Lyon, FranceCorevih Guyane, Cayenne Hospital, French Guiana, France; Infectious and Tropical Diseases Unit, Cayenne Hospital and French Guiana University, French Guiana, FranceSummary: Background: Adult T-cell leukemia/lymphoma (ATL), one of the most aggressive cancers in the world, occurs in 5% of the 10 million people living with HTLV-1 worldwide. French Guiana, a French overseas territory in South America, is one of the highest endemic areas of HTLV-1 worldwide. Here, we describe the demographic and clinical characteristics and outcome of ATL in this area. Methods: We retrospectively collected data from all patients diagnosed between 2009 and 2019. Patients were distributed according to Shimoyama's classification. Prognostic factors were explored through univariate analysis. Findings: Over the 10-year study period, 41 patients with a median age of 54 years at diagnosis were identified, among whom 56% were women. Sixteen (39%) patients were Maroons, a cultural group descendant of the runaway enslaved Africans from former Dutch Guiana. Among the study population, 23 (56%) had an acute type, 14 (34%) a lymphoma type, and one and one chronic and primary cutaneous tumour, respectively. First-lines of treatment included either chemotherapy or Zidovudine combined with pegylated interferon alpha. The 4-year overall survival was 11.4% for the entire population with 0% and 11% for lymphoma and acute forms, respectively. The median progression-free survival was 93 and 115 days for the acute and lymphoma groups (p = 0.37), respectively. Among the twenty-nine patients who died, 8 (28%) died of toxicity, 7 (24%) died of disease progression and the cause of death remained unknown in 14 (48%) patients. Due to the overall poor prognosis, no significant prognostic factors could be identified. Interpretation: This study provides real-life data from ATL patients in French Guiana, a remote territory in a middle-income region. Patients, mostly Maroons, presented with a younger age and the prognosis was worse than expected compared to Japanese patients. Funding: None.http://www.sciencedirect.com/science/article/pii/S2667193X23000662ATLHTLV-1French GuianaPrognosisRetrospective cohort |
| spellingShingle | Karim Abdelmoumen Kinan Drak Alsibai Sébastien Rabier Mathieu Nacher N'detodji-Bill Wankpo Antoine Gessain Florin Santa Olivier Hermine Ambroise Marçais Pierre Couppié Jean-Pierre Droz Loïc Epelboin Adult T-cell leukemia and lymphoma in French Guiana: a retrospective analysis with real-life data from 2009 to 2019Research in context The Lancet Regional Health. Americas ATL HTLV-1 French Guiana Prognosis Retrospective cohort |
| title | Adult T-cell leukemia and lymphoma in French Guiana: a retrospective analysis with real-life data from 2009 to 2019Research in context |
| title_full | Adult T-cell leukemia and lymphoma in French Guiana: a retrospective analysis with real-life data from 2009 to 2019Research in context |
| title_fullStr | Adult T-cell leukemia and lymphoma in French Guiana: a retrospective analysis with real-life data from 2009 to 2019Research in context |
| title_full_unstemmed | Adult T-cell leukemia and lymphoma in French Guiana: a retrospective analysis with real-life data from 2009 to 2019Research in context |
| title_short | Adult T-cell leukemia and lymphoma in French Guiana: a retrospective analysis with real-life data from 2009 to 2019Research in context |
| title_sort | adult t cell leukemia and lymphoma in french guiana a retrospective analysis with real life data from 2009 to 2019research in context |
| topic | ATL HTLV-1 French Guiana Prognosis Retrospective cohort |
| url | http://www.sciencedirect.com/science/article/pii/S2667193X23000662 |
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