Improved Adipose Tissue Function after Single Anastomosis Duodeno-Ileal Bypass with Sleeve-Gastrectomy (SADI-S) in Diet-Induced Obesity
Bariatric surgery has been recognized as the safest and most effective procedure for controlling type 2 diabetes (T2D) and obesity in carefully selected patients. The aim of the present study was to compare the effects of Sleeve Gastrectomy (SG) and Single Anastomosis Duodenoileal Bypass with SG (SA...
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/19/11641 |
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| author | Sara Becerril Carlota Tuero Javier A. Cienfuegos Amaia Rodríguez Victoria Catalán Beatriz Ramírez Víctor Valentí Rafael Moncada Xabier Unamuno Javier Gómez-Ambrosi Gema Frühbeck |
| author_facet | Sara Becerril Carlota Tuero Javier A. Cienfuegos Amaia Rodríguez Victoria Catalán Beatriz Ramírez Víctor Valentí Rafael Moncada Xabier Unamuno Javier Gómez-Ambrosi Gema Frühbeck |
| author_sort | Sara Becerril |
| collection | DOAJ |
| description | Bariatric surgery has been recognized as the safest and most effective procedure for controlling type 2 diabetes (T2D) and obesity in carefully selected patients. The aim of the present study was to compare the effects of Sleeve Gastrectomy (SG) and Single Anastomosis Duodenoileal Bypass with SG (SADI-S) on the metabolic profile of diet-induced obese rats. A total of 35 four-week-old male Wistar rats were submitted to surgical interventions (sham operation, SG and SADI-S) after 4 months of being fed a high-fat diet. Body weight, metabolic profile and the expression of molecules involved in the control of subcutaneous white (SCWAT), brown (BAT) and beige (BeAT) adipose tissue function were analyzed. SADI-S surgery was associated with significantly decreased amounts of total fat pads (<i>p</i> < 0.001) as well as better control of lipid and glucose metabolism compared to the SG counterparts. An improved expression of molecules involved in fat browning in SCWAT and in the control of BAT and BeAT differentiation and function was observed following SADI-S. Together, our findings provide evidence that the enhanced metabolic improvement and their continued durability after SADI-S compared to SG rely, at least in part, on the improvement of the BeAT phenotype and function. |
| first_indexed | 2024-03-09T21:38:12Z |
| format | Article |
| id | doaj.art-671a4ff783054b8182e512550473002e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:38:12Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-671a4ff783054b8182e512550473002e2023-11-23T20:36:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123191164110.3390/ijms231911641Improved Adipose Tissue Function after Single Anastomosis Duodeno-Ileal Bypass with Sleeve-Gastrectomy (SADI-S) in Diet-Induced ObesitySara Becerril0Carlota Tuero1Javier A. Cienfuegos2Amaia Rodríguez3Victoria Catalán4Beatriz Ramírez5Víctor Valentí6Rafael Moncada7Xabier Unamuno8Javier Gómez-Ambrosi9Gema Frühbeck10Metabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, SpainDepartment of Surgery, Clínica Universidad de Navarra, 31008 Pamplona, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, SpainMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, SpainMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, SpainMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, SpainMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, SpainMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, SpainMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, SpainBariatric surgery has been recognized as the safest and most effective procedure for controlling type 2 diabetes (T2D) and obesity in carefully selected patients. The aim of the present study was to compare the effects of Sleeve Gastrectomy (SG) and Single Anastomosis Duodenoileal Bypass with SG (SADI-S) on the metabolic profile of diet-induced obese rats. A total of 35 four-week-old male Wistar rats were submitted to surgical interventions (sham operation, SG and SADI-S) after 4 months of being fed a high-fat diet. Body weight, metabolic profile and the expression of molecules involved in the control of subcutaneous white (SCWAT), brown (BAT) and beige (BeAT) adipose tissue function were analyzed. SADI-S surgery was associated with significantly decreased amounts of total fat pads (<i>p</i> < 0.001) as well as better control of lipid and glucose metabolism compared to the SG counterparts. An improved expression of molecules involved in fat browning in SCWAT and in the control of BAT and BeAT differentiation and function was observed following SADI-S. Together, our findings provide evidence that the enhanced metabolic improvement and their continued durability after SADI-S compared to SG rely, at least in part, on the improvement of the BeAT phenotype and function.https://www.mdpi.com/1422-0067/23/19/11641sleeve gastrectomysingle anastomosis duodenoileal bypassdiet-induced obesitybrown adipose tissuebeige adipose tissue |
| spellingShingle | Sara Becerril Carlota Tuero Javier A. Cienfuegos Amaia Rodríguez Victoria Catalán Beatriz Ramírez Víctor Valentí Rafael Moncada Xabier Unamuno Javier Gómez-Ambrosi Gema Frühbeck Improved Adipose Tissue Function after Single Anastomosis Duodeno-Ileal Bypass with Sleeve-Gastrectomy (SADI-S) in Diet-Induced Obesity International Journal of Molecular Sciences sleeve gastrectomy single anastomosis duodenoileal bypass diet-induced obesity brown adipose tissue beige adipose tissue |
| title | Improved Adipose Tissue Function after Single Anastomosis Duodeno-Ileal Bypass with Sleeve-Gastrectomy (SADI-S) in Diet-Induced Obesity |
| title_full | Improved Adipose Tissue Function after Single Anastomosis Duodeno-Ileal Bypass with Sleeve-Gastrectomy (SADI-S) in Diet-Induced Obesity |
| title_fullStr | Improved Adipose Tissue Function after Single Anastomosis Duodeno-Ileal Bypass with Sleeve-Gastrectomy (SADI-S) in Diet-Induced Obesity |
| title_full_unstemmed | Improved Adipose Tissue Function after Single Anastomosis Duodeno-Ileal Bypass with Sleeve-Gastrectomy (SADI-S) in Diet-Induced Obesity |
| title_short | Improved Adipose Tissue Function after Single Anastomosis Duodeno-Ileal Bypass with Sleeve-Gastrectomy (SADI-S) in Diet-Induced Obesity |
| title_sort | improved adipose tissue function after single anastomosis duodeno ileal bypass with sleeve gastrectomy sadi s in diet induced obesity |
| topic | sleeve gastrectomy single anastomosis duodenoileal bypass diet-induced obesity brown adipose tissue beige adipose tissue |
| url | https://www.mdpi.com/1422-0067/23/19/11641 |
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