Adipokines as Regulators of Autophagy in Obesity-Linked Cancer
Excess body weight and obesity have become significant risk factors for cancer development. During obesity, adipose tissue alters its biological function, deregulating the secretion of bioactive factors such as hormones, cytokines, and adipokines that promote an inflammatory microenvironment conduci...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/20/3230 |
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| author | Alin García-Miranda Alejandra Garcia-Hernandez Eduardo Castañeda-Saucedo Napoleon Navarro-Tito Paola Maycotte |
| author_facet | Alin García-Miranda Alejandra Garcia-Hernandez Eduardo Castañeda-Saucedo Napoleon Navarro-Tito Paola Maycotte |
| author_sort | Alin García-Miranda |
| collection | DOAJ |
| description | Excess body weight and obesity have become significant risk factors for cancer development. During obesity, adipose tissue alters its biological function, deregulating the secretion of bioactive factors such as hormones, cytokines, and adipokines that promote an inflammatory microenvironment conducive to carcinogenesis and tumor progression. Adipokines regulate tumor processes such as apoptosis, proliferation, migration, angiogenesis, and invasion. Additionally, it has been found that they can modulate autophagy, a process implicated in tumor suppression in healthy tissue and cancer progression in established tumors. Since the tumor-promoting role of autophagy has been well described, the process has been suggested as a therapeutic target in cancer. However, the effects of targeting autophagy might depend on the tumor type and microenvironmental conditions, where circulating adipokines could influence the role of autophagy in cancer. Here, we review recent evidence related to the role of adipokines in cancer cell autophagy in an effort to understand the tumor response in the context of obesity under the assumption of an autophagy-targeting treatment. |
| first_indexed | 2024-03-09T20:29:08Z |
| format | Article |
| id | doaj.art-671d4b31904846b4bb46dfc8422513a0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T20:29:08Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-671d4b31904846b4bb46dfc8422513a02023-11-23T23:27:40ZengMDPI AGCells2073-44092022-10-011120323010.3390/cells11203230Adipokines as Regulators of Autophagy in Obesity-Linked CancerAlin García-Miranda0Alejandra Garcia-Hernandez1Eduardo Castañeda-Saucedo2Napoleon Navarro-Tito3Paola Maycotte4Laboratorio de Biología Celular del Cáncer, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39090, MexicoLaboratorio Estatal de Salud Pública, Secretaría de Salud, Chilpancingo 39715, MexicoLaboratorio de Biología Celular del Cáncer, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39090, MexicoLaboratorio de Biología Celular del Cáncer, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39090, MexicoCentro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla 74360, MexicoExcess body weight and obesity have become significant risk factors for cancer development. During obesity, adipose tissue alters its biological function, deregulating the secretion of bioactive factors such as hormones, cytokines, and adipokines that promote an inflammatory microenvironment conducive to carcinogenesis and tumor progression. Adipokines regulate tumor processes such as apoptosis, proliferation, migration, angiogenesis, and invasion. Additionally, it has been found that they can modulate autophagy, a process implicated in tumor suppression in healthy tissue and cancer progression in established tumors. Since the tumor-promoting role of autophagy has been well described, the process has been suggested as a therapeutic target in cancer. However, the effects of targeting autophagy might depend on the tumor type and microenvironmental conditions, where circulating adipokines could influence the role of autophagy in cancer. Here, we review recent evidence related to the role of adipokines in cancer cell autophagy in an effort to understand the tumor response in the context of obesity under the assumption of an autophagy-targeting treatment.https://www.mdpi.com/2073-4409/11/20/3230adipokinesautophagycancerobesityleptinadiponectin |
| spellingShingle | Alin García-Miranda Alejandra Garcia-Hernandez Eduardo Castañeda-Saucedo Napoleon Navarro-Tito Paola Maycotte Adipokines as Regulators of Autophagy in Obesity-Linked Cancer Cells adipokines autophagy cancer obesity leptin adiponectin |
| title | Adipokines as Regulators of Autophagy in Obesity-Linked Cancer |
| title_full | Adipokines as Regulators of Autophagy in Obesity-Linked Cancer |
| title_fullStr | Adipokines as Regulators of Autophagy in Obesity-Linked Cancer |
| title_full_unstemmed | Adipokines as Regulators of Autophagy in Obesity-Linked Cancer |
| title_short | Adipokines as Regulators of Autophagy in Obesity-Linked Cancer |
| title_sort | adipokines as regulators of autophagy in obesity linked cancer |
| topic | adipokines autophagy cancer obesity leptin adiponectin |
| url | https://www.mdpi.com/2073-4409/11/20/3230 |
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