Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report
Abstract Background Ethanol dependence is associated with a discontinuation withdrawal delirium. Chlordiazepoxide is frequently successfully used in its treatment. Case presentation A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening...
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-022-03456-x |
| _version_ | 1828760911735685120 |
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| author | Melissa A. Arabadjief Omar H. Elsayed Sabina Bashir Meenakshi R. Gundumalla Derek S. Menefee Cody L. Bergman Nayeem Z. Moulana Rif S. El-Mallakh |
| author_facet | Melissa A. Arabadjief Omar H. Elsayed Sabina Bashir Meenakshi R. Gundumalla Derek S. Menefee Cody L. Bergman Nayeem Z. Moulana Rif S. El-Mallakh |
| author_sort | Melissa A. Arabadjief |
| collection | DOAJ |
| description | Abstract Background Ethanol dependence is associated with a discontinuation withdrawal delirium. Chlordiazepoxide is frequently successfully used in its treatment. Case presentation A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening of her delirium after administration of chlordiazepoxide, but improved with lorazepam and cleared with discontinuation of benzodiazepine administration. Conclusions Worsening of delirium appears to be related to the specific use of chlordiazepoxide, but the mechanism of this effect is not clear. While this case does not alter the standard care of ethanol dependence, it does alert clinicians that our treatment approach may not be fully benign. |
| first_indexed | 2024-12-11T01:21:44Z |
| format | Article |
| id | doaj.art-671db01e1e314d46b6b2c66411dfd813 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-11T01:21:44Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-671db01e1e314d46b6b2c66411dfd8132022-12-22T01:25:41ZengBMCJournal of Medical Case Reports1752-19472022-07-011611410.1186/s13256-022-03456-xChlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case reportMelissa A. Arabadjief0Omar H. Elsayed1Sabina Bashir2Meenakshi R. Gundumalla3Derek S. Menefee4Cody L. Bergman5Nayeem Z. Moulana6Rif S. El-Mallakh7Department of Psychiatry and Behavioral Sciences, University of Louisville School of MedicineDepartment of Psychiatry and Behavioral Sciences, University of Louisville School of MedicineDepartment of Psychiatry and Behavioral Sciences, University of Louisville School of MedicineDepartment of Psychiatry and Behavioral Sciences, University of Louisville School of MedicineDepartment of Psychiatry and Behavioral Sciences, University of Louisville School of MedicineDepartment of Psychiatry and Behavioral Sciences, University of Louisville School of MedicineDepartment of Psychiatry and Behavioral Sciences, University of Louisville School of MedicineDepartment of Psychiatry and Behavioral Sciences, University of Louisville School of MedicineAbstract Background Ethanol dependence is associated with a discontinuation withdrawal delirium. Chlordiazepoxide is frequently successfully used in its treatment. Case presentation A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening of her delirium after administration of chlordiazepoxide, but improved with lorazepam and cleared with discontinuation of benzodiazepine administration. Conclusions Worsening of delirium appears to be related to the specific use of chlordiazepoxide, but the mechanism of this effect is not clear. While this case does not alter the standard care of ethanol dependence, it does alert clinicians that our treatment approach may not be fully benign.https://doi.org/10.1186/s13256-022-03456-xAcetylcholineAlcohol withdrawalBenzodiazepineCase reportChlordiazepoxideDelirium tremens |
| spellingShingle | Melissa A. Arabadjief Omar H. Elsayed Sabina Bashir Meenakshi R. Gundumalla Derek S. Menefee Cody L. Bergman Nayeem Z. Moulana Rif S. El-Mallakh Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report Journal of Medical Case Reports Acetylcholine Alcohol withdrawal Benzodiazepine Case report Chlordiazepoxide Delirium tremens |
| title | Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report |
| title_full | Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report |
| title_fullStr | Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report |
| title_full_unstemmed | Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report |
| title_short | Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report |
| title_sort | chlordiazepoxide induced delirium in a patient undergoing alcohol withdrawal a case report |
| topic | Acetylcholine Alcohol withdrawal Benzodiazepine Case report Chlordiazepoxide Delirium tremens |
| url | https://doi.org/10.1186/s13256-022-03456-x |
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