Establishment of iPSC (KRIBBi001-A) from CD34+ group O D-negative bone marrow blood
Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD−) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from g...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-03-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506121000453 |
| Summary: | Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD−) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from group O/RhD− sample as a new cellular source to generate universal RBCs. The resulting iPSC line derived from group O/RhD− somatic source showed typical features of pluripotent stem cells and could provide an unprecedented cellular tool to develop universal therapeutics for blood transfusion. |
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| ISSN: | 1873-5061 |