Comparative Hepatotoxicity of Fluconazole, Ketoconazole, Itraconazole, Terbinafine, and Griseofulvin in Rats

Comparative Hepatotoxicity of Fluconazole, Ketoconazole, Itraconazole, Terbinafine, and Griseofulvin in Rats

Oral ketoconazole was recently the subject of regulatory safety warnings because of its association with increased risk of inducing hepatic injury. However, the relative hepatotoxicity of antifungal agents has not been clearly established. The aim of this study was to compare the hepatotoxicity indu...

Descripció completa

Dades bibliogràfiques
Autors principals:	Star Khoza, Ishmael Moyo, Denver Ncube
Format:	Article
Idioma:	English
Publicat:	Hindawi Limited 2017-01-01
Col·lecció:	Journal of Toxicology
Accés en línia:	http://dx.doi.org/10.1155/2017/6746989

Ítems similars

In Vitro Comparison of MIC Crude Extracts of Active Actinomycetes Isolated with Terbinafine, Griseofulvin Ketoconazole and Fluconazole against Microsporum Canis, Microsporum Gypseum and Trichophyton Mentagrophytes
per: Keikha, N, et al.
Publicat: (2015-04-01)

Hepatotoxic effect of antifungal drugs itraconazole and fluconazole on rats
per: Yaacob, Azhar
Publicat: (2013)

Differential effects of ketoconazole, fluconazole, and itraconazole on the pharmacokinetics of pyrotinib in vitro and in vivo
per: Li Wang, et al.
Publicat: (2022-09-01)

Hepatotoxicity induced by antifungal drugs itraconazole and fluconazole in rats: a comparative in vivo study
per: Abdullah, Muhammad Nazrul Hakim, et al.
Publicat: (2004)

Efficacy and Safety of Oral Terbinafine with Itraconazole or Griseofulvin Combination Therapy in the Management of Dermatophytosis- A Randomised Clinical Trial
per: A Ramesh, et al.
Publicat: (2022-01-01)

An Analysis of the Use of Systemic Antifungals (Fluconazole, Itraconazole, and Terbinafine) in Galicia, Spain, between 2019 and 2022
per: Severo Vázquez-Prieto, et al.
Publicat: (2024-01-01)

Compare resistance and antifngal effects of Fluconazole, Itraconazole , Ketoconazole and nystatin on ( Candida albicans) isolated from Vulvovaginitis in Qom in 1395
per: Ameneh basem hamid, et al.
Publicat: (2018-09-01)

Comparative study of Griseofulvin versus Terbinafine in treatment of Tinea Corporis patients
per: K Vijaya Chandra Reddy, et al.
Publicat: (2016-01-01)

Antifungal effect of Allium sativum either individually or in combination with Fluconazole, Itraconazole and Ketoconazole against pathogenic yeasts
per: Atoosa Razzagh Parast (MSc), et al.
Publicat: (2009-05-01)

Chromomycosis Treatment With Combination Of Itraconazole And Terbinafine
per: Amalia Rositawati, et al.
Publicat: (2017-08-01)

Toxicity of Antifungal Drugs Itraconazole and Fluconazole in Rats
per: Abdul Rahman, Nor Shahida
Publicat: (2004)

Leukogram pada Infeksi Buatan Microsporum canis yang Diterapi Dengan Ketokonazole, Griseofulvin serta Kombinasi Griseofulvin dan Ketoconazole
per: , FIRDAUS AHADI, et al.
Publicat: (2013)

Comparision between therapeutic efficacy of terbinafine and ketoconazole in Tinea versicolor
per: Rostami Mogaddam M (MD), et al.
Publicat: (2011-02-01)

In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes
per: Aline Jacobi Dalla Lana, et al.
Publicat: (2018-07-01)

A randomized control study of oral itraconazole versus itraconazole with terbinafine in the treatment of dermatophytosis
per: Divya Sharma, et al.
Publicat: (2023-01-01)

Efficacy and Safety of Oral Itraconazole and Griseofulvin versus Itraconazole Alone in Patients with Tinea Corporis and Cruris Infection: A Comparative Clinical Study
per: Yagub Salem Saleh, et al.
Publicat: (2024-12-01)

Antifungal activities of fluconazole and ketoconazole agentsagainst Malassezia species
per: Mehdi Nazeri1, et al.
Publicat: (2009-01-01)

EFEK KOMBINASI GRISEOFULVIN DENGAN KETOCONAZOLE PADA PENGOBATAN INFEKSI Microsporum Canis PADA ANJING
per: , HENRI YUDAMUKTI PRIAWAN, et al.
Publicat: (2013)

A meta-analysis comparing efficacy of continuous terbinafine with intermittent itraconazole for toenail onychomycosis
per: Trivedi N, et al.
Publicat: (2010-01-01)

Itraconazole and fluconazole-induced toxicity in rat hepatocytes: a comparativein vitro study
per: Somchit, N, et al.
Publicat: (2002)

Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy
per: Heli Yang, et al.
Publicat: (2020-05-01)

PERBANDINGAN EFEKTIVITAS KETOCONAZOLE DAN GRISEOFULVIN TERHADAP PERKEMBANGAN LESI KULIT ANJING YANG DIINFEKSI Microsporum canis
per: , DWIATMOKO HARTONO, et al.
Publicat: (2013)

Esporotricose cutânea experimental: Avaliação in vivo do itraconazol e terbinafina Experimental cutaneous sporotrichosis: in vivo evaluation of itraconazole and terbinafine
per: Tatiana de Ávila Antunes, et al.
Publicat: (2009-12-01)

Effects of the CYP3A inhibitors, voriconazole, itraconazole, and fluconazole on the pharmacokinetics of osimertinib in rats
per: Yutao Lou, et al.
Publicat: (2023-08-01)

UPLC-MS/MS Measurement of the Effect of Isavuconazole, Itraconazole and Fluconazole on the Pharmacokinetics of Selinexor in Rats
per: Li S, et al.
Publicat: (2020-09-01)

Chiral separation of ketoconazole and itraconazole anti-fungal drugs using experimental and computational approaches /
per: Siti Rosilah Arsad, 1986-, author 491726, et al.
Publicat: (2019)

Chiral separation of ketoconazole and itraconazole anti-fungal drugs using experimental and computational approaches /
per: Siti Rosilah Arsad, 1986-, author 491726
Publicat: (2019)

Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis
per: Narges Alizadeh, et al.
Publicat: (2014-01-01)

Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans
per: Letícia Fernandes da Rocha, et al.
Publicat: (2020-09-01)

Gentiana lutea attenuates hepatotoxicity induced by ketoconazole in rats by fortifying the cellular antioxidant defense system
per: Alaaeldin Ahmed Hamza, et al.
Publicat: (2023-01-01)

Chromoblastomycosis murine model and in vitro test to evaluate the sensitivity of Fonsecaea pedrosoi to ketoconazole, itraconazole and saperconazole
per: Nora Cardona-Castro, et al.
Publicat: (1996-12-01)

A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine
per: Xu-Cheng Shen, et al.
Publicat: (2020-02-01)

Comparison of Efficacy of Double Dose Oral Terbinafine versus Itraconazole in the Treatment of Dermatophyte Infections of Skin
per: Umar Abdul Ali, et al.
Publicat: (2023-02-01)

Griseofulvin
per: 982 SIRIM

Suscetibilidade in vitro de isolados de Sporothrix schenckii frente à terbinafina e itraconazol In vitro susceptibility of isolates of Sporothrix schenckii to terbinafine and itraconazole
per: Ana Raquel Mano Meinerz, et al.
Publicat: (2007-02-01)

Comparison between the efficacy of terbinafine and itraconazole orally vs. the combination of the two drugs in treating recalcitrant dermatophytosis
per: Zinab Rabia Abo Almaati Hassaan, et al.
Publicat: (2023-11-01)

The Possible Efficacy of Artichoke in Fluconazole Related Hepatotoxicity
per: Hüseyin Kurt, et al.
Publicat: (2014-01-01)

Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes
per: Nhareet Somchit, et al.
Publicat: (2009-01-01)

Itraconazole Improves Vulvodynia in Fungus Culture-Negative Patients Post Fluconazole Failure
per: Rodger Rothenberger, MD, et al.
Publicat: (2021-08-01)

Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
per: Rodrigo Vettorato, et al.
Publicat: (2018-03-01)