Electrochemical Oxidation and Determination of Antiviral Drug Acyclovir by Modified Carbon Paste Electrode With Magnetic CdO Nanoparticles
With the development of nanomaterials in electrochemical sensors, the use of nanostructures to modify the electrode surface has been shown to improve the kinetics of the electron transfer process. In this study, a sensor was developed for the electrochemical determination of Acyclovir (ACV) based on...
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| Format: | Article |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2020.00689/full |
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| author | Ebrahim Naghian Ebrahim Naghian Ebrahim Naghian Elnaz Marzi Khosrowshahi Esmail Sohouli Hamid Reza Pazoki-Toroudi Ali Sobhani-Nasab Ali Sobhani-Nasab Mehdi Rahimi-Nasrabadi Mehdi Rahimi-Nasrabadi Farhad Ahmadi Farhad Ahmadi |
| author_facet | Ebrahim Naghian Ebrahim Naghian Ebrahim Naghian Elnaz Marzi Khosrowshahi Esmail Sohouli Hamid Reza Pazoki-Toroudi Ali Sobhani-Nasab Ali Sobhani-Nasab Mehdi Rahimi-Nasrabadi Mehdi Rahimi-Nasrabadi Farhad Ahmadi Farhad Ahmadi |
| author_sort | Ebrahim Naghian |
| collection | DOAJ |
| description | With the development of nanomaterials in electrochemical sensors, the use of nanostructures to modify the electrode surface has been shown to improve the kinetics of the electron transfer process. In this study, a sensor was developed for the electrochemical determination of Acyclovir (ACV) based on the modified carbon paste electrode (CPE) by CdO/Fe3O4. The magnetic CdO nanoparticles characterization was studied by energy-dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD). To study of the modified CPE surface morphology, scanning electron microscopy (SEM) was used. At the optimal conditions, a noteworthy enhancement in the electrochemical behavior of ACV was observed at the surface of the modified CPE compared to the unmodified CPE. A detection limit of 300 nM and a linear range of 1–100 μM were obtained for the quantitative monitoring of ACV at the modified CPE surface using differential pulse voltammetry (DPV) in phosphate buffer. The RSD% (relative standard deviation) of the electrode response was <4.3% indicating the development of a high precision method. Also, satisfactory results were obtained in the determination of ACV with the modified electrode in tablet, blood serum, and urine samples with a satisfactory relative recovery (RR%) in the range of 94.0–104.4%. |
| first_indexed | 2024-12-19T22:05:47Z |
| format | Article |
| id | doaj.art-6723cf00fbc34867a52d5dc4a0ce82b7 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-19T22:05:47Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-6723cf00fbc34867a52d5dc4a0ce82b72022-12-21T20:04:02ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462020-09-01810.3389/fchem.2020.00689556696Electrochemical Oxidation and Determination of Antiviral Drug Acyclovir by Modified Carbon Paste Electrode With Magnetic CdO NanoparticlesEbrahim Naghian0Ebrahim Naghian1Ebrahim Naghian2Elnaz Marzi Khosrowshahi3Esmail Sohouli4Hamid Reza Pazoki-Toroudi5Ali Sobhani-Nasab6Ali Sobhani-Nasab7Mehdi Rahimi-Nasrabadi8Mehdi Rahimi-Nasrabadi9Farhad Ahmadi10Farhad Ahmadi11Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, IranFaculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, IranDepartment of Chemistry, South Tehran Branch Islamic Azad University, Tehran, IranFaculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IranYoung Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, IranPhysiology Research Center, Iran University of Medical Sciences, Tehran, IranSocial Determinants of Health (SDH) Research Center, Kashan University of Medical Sciences, Kashan, IranCore Research Lab, Kashan University of Medical Sciences, Kashan, IranChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, IranFaculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, IranPhysiology Research Center, Iran University of Medical Sciences, Tehran, IranDepartment of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, IranWith the development of nanomaterials in electrochemical sensors, the use of nanostructures to modify the electrode surface has been shown to improve the kinetics of the electron transfer process. In this study, a sensor was developed for the electrochemical determination of Acyclovir (ACV) based on the modified carbon paste electrode (CPE) by CdO/Fe3O4. The magnetic CdO nanoparticles characterization was studied by energy-dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD). To study of the modified CPE surface morphology, scanning electron microscopy (SEM) was used. At the optimal conditions, a noteworthy enhancement in the electrochemical behavior of ACV was observed at the surface of the modified CPE compared to the unmodified CPE. A detection limit of 300 nM and a linear range of 1–100 μM were obtained for the quantitative monitoring of ACV at the modified CPE surface using differential pulse voltammetry (DPV) in phosphate buffer. The RSD% (relative standard deviation) of the electrode response was <4.3% indicating the development of a high precision method. Also, satisfactory results were obtained in the determination of ACV with the modified electrode in tablet, blood serum, and urine samples with a satisfactory relative recovery (RR%) in the range of 94.0–104.4%.https://www.frontiersin.org/article/10.3389/fchem.2020.00689/fullacyclovirantiviral drugcarbon paste electrodeelectrochemical sensormagnetic cadmium oxidenanoparticle |
| spellingShingle | Ebrahim Naghian Ebrahim Naghian Ebrahim Naghian Elnaz Marzi Khosrowshahi Esmail Sohouli Hamid Reza Pazoki-Toroudi Ali Sobhani-Nasab Ali Sobhani-Nasab Mehdi Rahimi-Nasrabadi Mehdi Rahimi-Nasrabadi Farhad Ahmadi Farhad Ahmadi Electrochemical Oxidation and Determination of Antiviral Drug Acyclovir by Modified Carbon Paste Electrode With Magnetic CdO Nanoparticles Frontiers in Chemistry acyclovir antiviral drug carbon paste electrode electrochemical sensor magnetic cadmium oxide nanoparticle |
| title | Electrochemical Oxidation and Determination of Antiviral Drug Acyclovir by Modified Carbon Paste Electrode With Magnetic CdO Nanoparticles |
| title_full | Electrochemical Oxidation and Determination of Antiviral Drug Acyclovir by Modified Carbon Paste Electrode With Magnetic CdO Nanoparticles |
| title_fullStr | Electrochemical Oxidation and Determination of Antiviral Drug Acyclovir by Modified Carbon Paste Electrode With Magnetic CdO Nanoparticles |
| title_full_unstemmed | Electrochemical Oxidation and Determination of Antiviral Drug Acyclovir by Modified Carbon Paste Electrode With Magnetic CdO Nanoparticles |
| title_short | Electrochemical Oxidation and Determination of Antiviral Drug Acyclovir by Modified Carbon Paste Electrode With Magnetic CdO Nanoparticles |
| title_sort | electrochemical oxidation and determination of antiviral drug acyclovir by modified carbon paste electrode with magnetic cdo nanoparticles |
| topic | acyclovir antiviral drug carbon paste electrode electrochemical sensor magnetic cadmium oxide nanoparticle |
| url | https://www.frontiersin.org/article/10.3389/fchem.2020.00689/full |
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