Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation through inhibiting COX-2

Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation through inhibiting COX-2

The mechanisms of Salvia miltiorrhiza (SM) and Tanshinone IIA (Tan IIA) in the treatment of atherosclerosis was examined by combining network pharmacology and molecular biology experiments. The TCMSP and BATMAN-TCM databases provided 104 SM candidate ingredients and 813 target genes, while GEO and G...

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Bibliographic Details
Main Authors: Xiangke Ma, Lei Zhang, Fujun Gao, Weihua Jia, Chao Li
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Salvia miltiorrhiza
Tanshinone IIA
Coronary artery disease
Atherosclerosis
Network pharmacology
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223012994

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http://www.sciencedirect.com/science/article/pii/S0753332223012994

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