Crosstalk between CD4 T cells and synovial fibroblasts from human arthritic joints promotes hyaluronan-dependent leukocyte adhesion and inflammatory cytokine expression in vitro

Crosstalk between CD4 T cells and synovial fibroblasts from human arthritic joints promotes hyaluronan-dependent leukocyte adhesion and inflammatory cytokine expression in vitro

The content and organization of hyaluronan (HA) in the extracellular matrix (ECM) have been identified as strong indicators of inflammation in joint disease, although the source and role of HA as an effector of inflammation is not clear. In this study, we established co-cultures of activated human C...

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Bibliographic Details
Main Authors: Inkyung Kang, Christian Hundhausen, Stephen P. Evanko, Prasanthi Malapati, Gail Workman, Christina K. Chan, Cliff Rims, Gary S. Firestein, David L. Boyle, Kevin M. MacDonald, Jane H. Buckner, Thomas N. Wight
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Matrix Biology Plus
Subjects:
Arthritis
Extracellular matrix
Hyaluronan
IL6
Synovial fibroblasts
Online Access:http://www.sciencedirect.com/science/article/pii/S2590028522000102

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