Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection.
<h4>Background</h4>Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in p...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0243882 |
| _version_ | 1818581091810803712 |
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| author | Laurie G Jacobs Elli Gourna Paleoudis Dineen Lesky-Di Bari Themba Nyirenda Tamara Friedman Anjali Gupta Lily Rasouli Marygrace Zetkulic Bindu Balani Chinwe Ogedegbe Harinder Bawa Lauren Berrol Nabiha Qureshi Judy L Aschner |
| author_facet | Laurie G Jacobs Elli Gourna Paleoudis Dineen Lesky-Di Bari Themba Nyirenda Tamara Friedman Anjali Gupta Lily Rasouli Marygrace Zetkulic Bindu Balani Chinwe Ogedegbe Harinder Bawa Lauren Berrol Nabiha Qureshi Judy L Aschner |
| author_sort | Laurie G Jacobs |
| collection | DOAJ |
| description | <h4>Background</h4>Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitalization and their impact on quality of life, health, physical, mental, and psychosocial function.<h4>Methods and findings</h4>This prospective cohort study used the PROMIS® Instruments to identify symptoms and quality of life parameters in consecutively enrolled patients between March 22 and April 16, 2020, in New Jersey. The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI: 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI: 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI: 0.016, 0.193], p <0.0001), mental health (43.7%, OR 0.093 [95% CI: 0.021, 0.418], p = 0.0019) and social active role (38.7%, OR 0.095 [95% CI: 0.031, 0.291], p<0.0001), as very good/excellent, particularly adults aged 65 to 75 years (OR 8·666 [95% CI: 2·216, 33·884], p = 0·0019).<h4>Conclusions</h4>COVID-19 symptoms commonly persist to 35 days, impacting quality of life, health, physical and mental function. Early post-acute evaluation of symptoms and their impact on function is necessary to plan community-based services. |
| first_indexed | 2024-12-16T07:27:59Z |
| format | Article |
| id | doaj.art-672a19a9ed864f8f94c28b32ee104e27 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T07:27:59Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-672a19a9ed864f8f94c28b32ee104e272022-12-21T22:39:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011512e024388210.1371/journal.pone.0243882Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection.Laurie G JacobsElli Gourna PaleoudisDineen Lesky-Di BariThemba NyirendaTamara FriedmanAnjali GuptaLily RasouliMarygrace ZetkulicBindu BalaniChinwe OgedegbeHarinder BawaLauren BerrolNabiha QureshiJudy L Aschner<h4>Background</h4>Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitalization and their impact on quality of life, health, physical, mental, and psychosocial function.<h4>Methods and findings</h4>This prospective cohort study used the PROMIS® Instruments to identify symptoms and quality of life parameters in consecutively enrolled patients between March 22 and April 16, 2020, in New Jersey. The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI: 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI: 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI: 0.016, 0.193], p <0.0001), mental health (43.7%, OR 0.093 [95% CI: 0.021, 0.418], p = 0.0019) and social active role (38.7%, OR 0.095 [95% CI: 0.031, 0.291], p<0.0001), as very good/excellent, particularly adults aged 65 to 75 years (OR 8·666 [95% CI: 2·216, 33·884], p = 0·0019).<h4>Conclusions</h4>COVID-19 symptoms commonly persist to 35 days, impacting quality of life, health, physical and mental function. Early post-acute evaluation of symptoms and their impact on function is necessary to plan community-based services.https://doi.org/10.1371/journal.pone.0243882 |
| spellingShingle | Laurie G Jacobs Elli Gourna Paleoudis Dineen Lesky-Di Bari Themba Nyirenda Tamara Friedman Anjali Gupta Lily Rasouli Marygrace Zetkulic Bindu Balani Chinwe Ogedegbe Harinder Bawa Lauren Berrol Nabiha Qureshi Judy L Aschner Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection. PLoS ONE |
| title | Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection. |
| title_full | Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection. |
| title_fullStr | Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection. |
| title_full_unstemmed | Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection. |
| title_short | Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection. |
| title_sort | persistence of symptoms and quality of life at 35 days after hospitalization for covid 19 infection |
| url | https://doi.org/10.1371/journal.pone.0243882 |
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