The potentials of human adipose tissue derived mesenchymal stem cells in targeted therapy of experimental glioma
Glioblastoma is the most common primary malignant brain tumor in adults. With current standard therapy which includes extensive microsurgical resection along with concurrent chemoradiotherapy and adjuvant temozolomide (TMZ), the median survival of glioblastoma patients is only 14.60 months nowadays....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tianjin Huanhu Hospital
2012-12-01
|
| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/616 |
| _version_ | 1819315411461603328 |
|---|---|
| author | Cun⁃gang FAN Qing⁃jun ZHANG |
| author_facet | Cun⁃gang FAN Qing⁃jun ZHANG |
| author_sort | Cun⁃gang FAN |
| collection | DOAJ |
| description | Glioblastoma is the most common primary malignant brain tumor in adults. With current standard therapy which includes extensive microsurgical resection along with concurrent chemoradiotherapy and adjuvant temozolomide (TMZ), the median survival of glioblastoma patients is only 14.60 months nowadays. Recent studies demonstrated that human adipose tissue derived mesenchymal stem cells (hAT⁃ MSCs) possessed the glioma ⁃ trophic migratory capacity. The engineered hAT ⁃ MSCs expressing herpes simplex virus⁃thymidine kinase (HSV⁃tk), yeast cytosine deaminase::uracil phosphoribosyltransferase (CDy:: UPRT), and rabbit carboxylesterase (rCE) could exert inhibitory effects on glioma when combined with prodrugs, such as ganciclovir (GCV), 5⁃fluorocytosine (5⁃FC) and irinotecan (CPT⁃11), respectively. hAT⁃ MSCs carrying the oncolytic virus or expressing tumor necrosis factor ⁃ related apoptosis ⁃ inducing ligand (TRAIL) also could inhibit the growth of glioma. This paper summarizes the recent progress in this field to pave the way for hAT⁃MSCs based targeted therapy of glioma in future.
DOI：10.3969/j.issn.1672⁃6731.2012.06.005 |
| first_indexed | 2024-12-24T09:59:41Z |
| format | Article |
| id | doaj.art-672a7f98392042fda715619fa65ee872 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-24T09:59:41Z |
| publishDate | 2012-12-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-672a7f98392042fda715619fa65ee8722022-12-21T17:01:08ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312012-12-01126651654615The potentials of human adipose tissue derived mesenchymal stem cells in targeted therapy of experimental gliomaCun⁃gang FANQing⁃jun ZHANGGlioblastoma is the most common primary malignant brain tumor in adults. With current standard therapy which includes extensive microsurgical resection along with concurrent chemoradiotherapy and adjuvant temozolomide (TMZ), the median survival of glioblastoma patients is only 14.60 months nowadays. Recent studies demonstrated that human adipose tissue derived mesenchymal stem cells (hAT⁃ MSCs) possessed the glioma ⁃ trophic migratory capacity. The engineered hAT ⁃ MSCs expressing herpes simplex virus⁃thymidine kinase (HSV⁃tk), yeast cytosine deaminase::uracil phosphoribosyltransferase (CDy:: UPRT), and rabbit carboxylesterase (rCE) could exert inhibitory effects on glioma when combined with prodrugs, such as ganciclovir (GCV), 5⁃fluorocytosine (5⁃FC) and irinotecan (CPT⁃11), respectively. hAT⁃ MSCs carrying the oncolytic virus or expressing tumor necrosis factor ⁃ related apoptosis ⁃ inducing ligand (TRAIL) also could inhibit the growth of glioma. This paper summarizes the recent progress in this field to pave the way for hAT⁃MSCs based targeted therapy of glioma in future. DOI：10.3969/j.issn.1672⁃6731.2012.06.005http://www.cjcnn.org/index.php/cjcnn/article/view/616Mesenchymal stem cell transplantationDrug carriersAdipose tissueNeoplasms, experimentalGliomaReview |
| spellingShingle | Cun⁃gang FAN Qing⁃jun ZHANG The potentials of human adipose tissue derived mesenchymal stem cells in targeted therapy of experimental glioma Chinese Journal of Contemporary Neurology and Neurosurgery Mesenchymal stem cell transplantation Drug carriers Adipose tissue Neoplasms, experimental Glioma Review |
| title | The potentials of human adipose tissue derived mesenchymal stem cells in targeted therapy of experimental glioma |
| title_full | The potentials of human adipose tissue derived mesenchymal stem cells in targeted therapy of experimental glioma |
| title_fullStr | The potentials of human adipose tissue derived mesenchymal stem cells in targeted therapy of experimental glioma |
| title_full_unstemmed | The potentials of human adipose tissue derived mesenchymal stem cells in targeted therapy of experimental glioma |
| title_short | The potentials of human adipose tissue derived mesenchymal stem cells in targeted therapy of experimental glioma |
| title_sort | potentials of human adipose tissue derived mesenchymal stem cells in targeted therapy of experimental glioma |
| topic | Mesenchymal stem cell transplantation Drug carriers Adipose tissue Neoplasms, experimental Glioma Review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/616 |
| work_keys_str_mv | AT cungangfan thepotentialsofhumanadiposetissuederivedmesenchymalstemcellsintargetedtherapyofexperimentalglioma AT qingjunzhang thepotentialsofhumanadiposetissuederivedmesenchymalstemcellsintargetedtherapyofexperimentalglioma AT cungangfan potentialsofhumanadiposetissuederivedmesenchymalstemcellsintargetedtherapyofexperimentalglioma AT qingjunzhang potentialsofhumanadiposetissuederivedmesenchymalstemcellsintargetedtherapyofexperimentalglioma |