Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam

We tested pre-pandemic (2015–-2019) plasma samples from 148 Vietnamese children and 100 Vietnamese adults at high risk of zoonotic infections for antibodies against SARS-CoV-2 nucleocapsid and spike proteins. None was positive. The data thus demonstrated no evidence of prior serological cross-reacti...

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Main Authors: Nguyen Van Vinh Chau, Le Nguyen Thanh Nhan, Lam Anh Nguyet, Nguyen Thi Kha Tu, Nguyen Thi Thu Hong, Dinh Nguyen Huy Man, Dinh Thi Bich Ty, Le Nguyen Truc Nhu, Lam Minh Yen, Truong Huu Khanh, Du Tuan Quy, Ngo Ngoc Quang Minh, Nguyen Thi Han Ny, Danielle Anderson, Lin-Fa Wang, H. Rogier van Doorn, Nguyen Thanh Hung, Tran Tan Thanh, Guy Thwaites, Le Van Tan
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:International Journal of Infectious Diseases
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971221006299
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author Nguyen Van Vinh Chau
Le Nguyen Thanh Nhan
Lam Anh Nguyet
Nguyen Thi Kha Tu
Nguyen Thi Thu Hong
Dinh Nguyen Huy Man
Dinh Thi Bich Ty
Le Nguyen Truc Nhu
Lam Minh Yen
Truong Huu Khanh
Du Tuan Quy
Ngo Ngoc Quang Minh
Nguyen Thi Han Ny
Danielle Anderson
Lin-Fa Wang
H. Rogier van Doorn
Nguyen Thanh Hung
Tran Tan Thanh
Guy Thwaites
Le Van Tan
author_facet Nguyen Van Vinh Chau
Le Nguyen Thanh Nhan
Lam Anh Nguyet
Nguyen Thi Kha Tu
Nguyen Thi Thu Hong
Dinh Nguyen Huy Man
Dinh Thi Bich Ty
Le Nguyen Truc Nhu
Lam Minh Yen
Truong Huu Khanh
Du Tuan Quy
Ngo Ngoc Quang Minh
Nguyen Thi Han Ny
Danielle Anderson
Lin-Fa Wang
H. Rogier van Doorn
Nguyen Thanh Hung
Tran Tan Thanh
Guy Thwaites
Le Van Tan
author_sort Nguyen Van Vinh Chau
collection DOAJ
description We tested pre-pandemic (2015–-2019) plasma samples from 148 Vietnamese children and 100 Vietnamese adults at high risk of zoonotic infections for antibodies against SARS-CoV-2 nucleocapsid and spike proteins. None was positive. The data thus demonstrated no evidence of prior serological cross-reactivity with SARS-CoV-2 that might explain the low numbers of COVID-19 in Vietnam. No pre-existing cross-reactivity might explain Vietnam success of COVID-19 control.
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spelling doaj.art-672af21ae5fb41f996c4818f5934dc0c2022-12-21T20:45:24ZengElsevierInternational Journal of Infectious Diseases1201-97122021-10-01111127129Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in VietnamNguyen Van Vinh Chau0Le Nguyen Thanh Nhan1Lam Anh Nguyet2Nguyen Thi Kha Tu3Nguyen Thi Thu Hong4Dinh Nguyen Huy Man5Dinh Thi Bich Ty6Le Nguyen Truc Nhu7Lam Minh Yen8Truong Huu Khanh9Du Tuan Quy10Ngo Ngoc Quang Minh11Nguyen Thi Han Ny12Danielle Anderson13Lin-Fa Wang14H. Rogier van Doorn15Nguyen Thanh Hung16Tran Tan Thanh17Guy Thwaites18Le Van Tan19Hospital for Tropical Diseases, Ho Chi Minh City, VietnamChildren's Hospital 1, Ho Chi Minh City, VietnamOxford University Clinical Research Unit, Ho Chi Minh City, VietnamDong Thap Provincial Center for Disease Control, Dong Thap Province, VietnamOxford University Clinical Research Unit, Ho Chi Minh City, VietnamHospital for Tropical Diseases, Ho Chi Minh City, VietnamHospital for Tropical Diseases, Ho Chi Minh City, VietnamOxford University Clinical Research Unit, Ho Chi Minh City, VietnamOxford University Clinical Research Unit, Ho Chi Minh City, VietnamChildren's Hospital 1, Ho Chi Minh City, VietnamChildren's Hospital 1, Ho Chi Minh City, VietnamChildren's Hospital 1, Ho Chi Minh City, VietnamOxford University Clinical Research Unit, Ho Chi Minh City, VietnamDuke-NUS Medical School, SingaporeDuke-NUS Medical School, Singapore; SingHealth Duke-NUS Global Health Institute, SingaporeOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UKChildren's Hospital 1, Ho Chi Minh City, VietnamOxford University Clinical Research Unit, Ho Chi Minh City, VietnamOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UKOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Correspondence: Le Van TanWe tested pre-pandemic (2015–-2019) plasma samples from 148 Vietnamese children and 100 Vietnamese adults at high risk of zoonotic infections for antibodies against SARS-CoV-2 nucleocapsid and spike proteins. None was positive. The data thus demonstrated no evidence of prior serological cross-reactivity with SARS-CoV-2 that might explain the low numbers of COVID-19 in Vietnam. No pre-existing cross-reactivity might explain Vietnam success of COVID-19 control.http://www.sciencedirect.com/science/article/pii/S1201971221006299Cross-reactivitySARS-CoV-2zoonosisCOVID-19
spellingShingle Nguyen Van Vinh Chau
Le Nguyen Thanh Nhan
Lam Anh Nguyet
Nguyen Thi Kha Tu
Nguyen Thi Thu Hong
Dinh Nguyen Huy Man
Dinh Thi Bich Ty
Le Nguyen Truc Nhu
Lam Minh Yen
Truong Huu Khanh
Du Tuan Quy
Ngo Ngoc Quang Minh
Nguyen Thi Han Ny
Danielle Anderson
Lin-Fa Wang
H. Rogier van Doorn
Nguyen Thanh Hung
Tran Tan Thanh
Guy Thwaites
Le Van Tan
Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam
International Journal of Infectious Diseases
Cross-reactivity
SARS-CoV-2
zoonosis
COVID-19
title Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam
title_full Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam
title_fullStr Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam
title_full_unstemmed Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam
title_short Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam
title_sort absence of sars cov 2 antibodies in pre pandemic plasma from children and adults in vietnam
topic Cross-reactivity
SARS-CoV-2
zoonosis
COVID-19
url http://www.sciencedirect.com/science/article/pii/S1201971221006299
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