Parallel Synthesis of 2-Substituted 6-(5-Oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides

Parallel Synthesis of 2-Substituted 6-(5-Oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides

A library of 24 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides <strong>10</strong>{<em>1</em>,<em>2</em>; <em>1–12</em>} was prepared by a parallel solution-phase approach. The...

Full description

Bibliographic Details
Main Authors:	Branko Stanovnik, Uroš Grošelj, Jurij Svete, Georg Dahmann, Drago Kočar, Jernej Baškovč, Bojana Črček
Format:	Article
Language:	English
Published:	MDPI AG 2012-05-01
Series:	Molecules
Subjects:	parallel synthesis pyrimidines 2-(heteroaryl)ethylamines
Online Access:	http://www.mdpi.com/1420-3049/17/5/5363

Similar Items

Synthesis of 3-(2-aminoethyl)-5-hydroxy-1H-pyrazole derivatives
by: Uroš Grošelj, et al.
Published: (2011-11-01)

4,5,6-Trichloropyrimidine-2-carboxamide
by: Andreas S. Kalogirou, et al.
Published: (2021-02-01)

Transformations of (Z)-2-benzoylamino-4-dimethylamino-2-oxo-3-butene and (E)-3-benzoylamino-4-cyano-2-oxo-3-butene into pyrimidine, pyrazole and isoxazole derivatives
by: Urska Bratusek, et al.
Published: (2003-04-01)

4,6-Diamino-5-(3,4-dichlorobenzylidene)pyrimidin-2(5H)-one
by: Antonieta Taddei, et al.
Published: (2010-09-01)

1-(4-Bromobenzoyl)-2-phenylpyrrolidine-2-carboxamide
by: Vahan Martirosyan, et al.
Published: (2008-03-01)

Pyrimidine 5’Nucleotidase I and II Activities in Acute Leukaemias
by: Haci Kemal Erdemli, et al.
Published: (2004-01-01)

Heteroaryl Chalcones: Design, Synthesis, X-ray Crystal Structures and Biological Evaluation
by: Hoong-Kun Fun, et al.
Published: (2013-10-01)

Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles
by: Hussein El-Kashef, et al.
Published: (2010-04-01)

Design and Synthesis of Novel Indole Ethylamine Derivatives as a Lipid Metabolism Regulator Targeting PPARα/CPT1 in AML12 Cells
by: Yu-Chen Liu, et al.
Published: (2023-12-01)

Facilely reducing recalcitrance of lignocellulosic biomass by a newly developed ethylamine-based deep eutectic solvent for biobutanol fermentation
by: Guochao Xu, et al.
Published: (2020-10-01)

Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives
by: Yanjun Xu, et al.
Published: (2011-10-01)

Electrochemical behavior of some new pyrimidine derivatives
by: MUSTAFA LUTFU BERKEM, et al.
Published: (2004-09-01)

Electrochemical behavior of some new pyrimidine derivatives
by: Kiliç Hasan, et al.
Published: (2004-01-01)

Synthesis of five membered ring hetero cyclic compounds derived from methyl-6- methyl-2- oxo-4-substituted 1,2,3,4- tetrahydro pyrimidine-5-carboxylate
by: Shaima S. Ismmaeel
Published: (2018-03-01)

Crystal structure, electrochemical and spectroscopic investigation of mer-tris[2-(1H-imidazol-2-yl-κN3)pyrimidine-κN1]ruthenium(II) bis(hexafluoridophosphate) trihydrate
by: Naheed Bibi, et al.
Published: (2018-07-01)

A Review on Fused Pyrimidine Systems as EGFR Inhibitors and Their Structure–Activity Relationship
by: Tanuja T. Yadav, et al.
Published: (2022-06-01)

(Acetato-κO){2-[(2-aminoethyl-κN)disulfanyl]ethanaminium}dichloridozinc(II)
by: Naoto Kuwamura, et al.
Published: (2016-01-01)

Design, Synthesis, and Antibacterial Screening of Some Novel Heteroaryl-Based Ciprofloxacin Derivatives as DNA Gyrase and Topoisomerase IV Inhibitors
by: Lamya H. Al-Wahaibi, et al.
Published: (2021-04-01)

Pyrimidine and Pyrrolidine Compounds /
by: Hendrix, Tabatha, author 648455, et al.
Published: (2012)

The Administration of the New Pyrimidine Derivative—4-{2-[2-(3,4-Dimethoxyphenyl)-Vinyl]-6-Ethyl-4-Oxo-5-Phenyl-4H-Pyrimidine-1-Il}Benzsulfamide Restores the Activity of Brain Cells in Experimental Chronic Traumatic Encephalopathy by Maintaining Mitochondrial Function
by: Dmitry I. Pozdnyakov, et al.
Published: (2019-07-01)

Reactions of Polychlorinated Pyrimidines with DABCO
by: Andreas S. Kalogirou, et al.
Published: (2019-10-01)

2-Amino-5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one
by: Sanae Lahmidi, et al.
Published: (2018-11-01)

9-(1H-Benzo[d]imidazol-2-yl)-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline
by: Gerardo García González, et al.
Published: (2017-03-01)

Synthesis of N-Heteroarenemethyl Esters via C–C Bond Cleavage of Acyl Cyanides Under Transition Metal-Free Conditions
by: Miao Lai, et al.
Published: (2022-01-01)

A rare mutation (p.F149del) of the NT5C3A gene is associated with pyrimidine 5′-nucleotidase deficiency
by: Dżamila M. Bogusławska, et al.
Published: (2022-11-01)

4-Chloro-6-ethoxy-2-(methylthio)pyrimidine
by: Andreas S. Kalogirou, et al.
Published: (2016-12-01)

2-(2-Amino-5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7-yl)acetohydrazide monohydrate
by: Sanae Lahmidi, et al.
Published: (2016-06-01)

4-Amino-6-(piperidin-1-yl)pyrimidine-5-carbonitrile
by: Radhika Bhat, et al.
Published: (2020-03-01)

Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine
by: Wanyan Wang, et al.
Published: (2021-05-01)

Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents
by: Alexander Zubenko, et al.
Published: (2022-11-01)

Heteroaryl-Ethylenes as New Effective Agents for High Priority Gram-Positive and Gram-Negative Bacterial Clinical Isolates
by: Dalida Angela Bivona, et al.
Published: (2022-06-01)

Deoxygenative C2-heteroarylation of quinoline N-oxides: facile access to α-triazolylquinolines
by: Geetanjali S. Sontakke, et al.
Published: (2021-02-01)

Unexpected reactions of 7-amino-8-nitrotetrazolo[1,5-c]pyrimidine
by: Zhi-wei Zeng, et al.
Published: (2021-12-01)

Anti-Mycobacterial Activity of Flavonoid and Pyrimidine Compounds
by: Saurabh Garg, et al.
Published: (2022-10-01)

Inhibition Properties of Some Pyrimidine Derivatives as Anticancer Agents on Glutathione S-Transferase
by: Hatice Esra Duran
Published: (2021-10-01)

Severe Encephalopathy, Lactic Acidosis, Vegetative Instability and Neuropathy with 5-Fluorouracil Treatment – Pyrimidine Degradation Defect or Beriberi
by: A. Rosen, et al.
Published: (2011-08-01)

Synthesis and Antitumor Evaluation of Novel Dihydropyrimidine, Thiazolo[3,2-a]Pyrimidine and Pyrano[2,3-d]Pyrimidine Derivatives
by: Nadia Y. Megally Abdo
Published: (2015-01-01)

Synthesis and Antimicrobial Evaluation of Novel Pyrazole, Imidazole and Pyrimidine Derivatives Possessing Imidazo[4,5-b]indol Moiety
by: Nadia Ali Ahmed Elkanzi, et al.
Published: (2019-12-01)

Fresh insights into the pyrimidine metabolism in the trypanosomatids
by: Kartikeya Tiwari, et al.
Published: (2018-02-01)

8-(Pyrimidin-2-yl)-1,2,3,4,5,6,7,8-heptathiazocane
by: Vladimir A. Ogurtsov, et al.
Published: (2019-11-01)