Sol-Gel-Derived Fibers Based on Amorphous <i>α</i>-Hydroxy-Carboxylate-Modified Titanium(IV) Oxide as a 3-Dimensional Scaffold
The development of novel fibrous biomaterials and further processing of medical devices is still challenging. For instance, titanium(IV) oxide is a well-established biocompatible material, and the synthesis of TiO<sub>x</sub> particles and coatings via the sol-gel process has frequently...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/15/8/2752 |
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| author | Bastian Christ Walther Glaubitt Katrin Berberich Tobias Weigel Jörn Probst Gerhard Sextl Sofia Dembski |
| author_facet | Bastian Christ Walther Glaubitt Katrin Berberich Tobias Weigel Jörn Probst Gerhard Sextl Sofia Dembski |
| author_sort | Bastian Christ |
| collection | DOAJ |
| description | The development of novel fibrous biomaterials and further processing of medical devices is still challenging. For instance, titanium(IV) oxide is a well-established biocompatible material, and the synthesis of TiO<sub>x</sub> particles and coatings via the sol-gel process has frequently been published. However, synthesis protocols of sol-gel-derived TiO<sub>x</sub> fibers are hardly known. In this publication, the authors present a synthesis and fabrication of purely sol-gel-derived TiO<sub>x</sub> fiber fleeces starting from the liquid sol-gel precursor titanium ethylate (TEOT). Here, the <i>α</i>-hydroxy-carboxylic acid lactic acid (LA) was used as a chelating ligand to reduce the reactivity towards hydrolysis of TEOT enabling a spinnable sol. The resulting fibers were processed into a non-woven fleece, characterized with FTIR, <sup>13</sup>C-MAS-NMR, XRD, and screened with regard to their stability in physiological solution. They revealed an unexpected dependency between the LA content and the dissolution behavior. Finally, in vitro cell culture experiments proved their potential suitability as an open-mesh structured scaffold material, even for challenging applications such as therapeutic medicinal products (ATMPs). |
| first_indexed | 2024-03-09T10:32:00Z |
| format | Article |
| id | doaj.art-672e35169b3743e6be2577697111a890 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T10:32:00Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-672e35169b3743e6be2577697111a8902023-12-01T21:11:00ZengMDPI AGMaterials1996-19442022-04-01158275210.3390/ma15082752Sol-Gel-Derived Fibers Based on Amorphous <i>α</i>-Hydroxy-Carboxylate-Modified Titanium(IV) Oxide as a 3-Dimensional ScaffoldBastian Christ0Walther Glaubitt1Katrin Berberich2Tobias Weigel3Jörn Probst4Gerhard Sextl5Sofia Dembski6Fraunhofer Institute for Silicate Research ISC, Translational Center Regenerative Therapies TLC-RT, Neunerplatz 2, 97082 Würzburg, GermanyFraunhofer Institute for Silicate Research ISC, Translational Center Regenerative Therapies TLC-RT, Neunerplatz 2, 97082 Würzburg, GermanyFraunhofer Institute for Silicate Research ISC, Translational Center Regenerative Therapies TLC-RT, Neunerplatz 2, 97082 Würzburg, GermanyFraunhofer Institute for Silicate Research ISC, Translational Center Regenerative Therapies TLC-RT, Neunerplatz 2, 97082 Würzburg, GermanyFraunhofer Institute for Silicate Research ISC, Translational Center Regenerative Therapies TLC-RT, Neunerplatz 2, 97082 Würzburg, GermanyFraunhofer Institute for Silicate Research ISC, Translational Center Regenerative Therapies TLC-RT, Neunerplatz 2, 97082 Würzburg, GermanyFraunhofer Institute for Silicate Research ISC, Translational Center Regenerative Therapies TLC-RT, Neunerplatz 2, 97082 Würzburg, GermanyThe development of novel fibrous biomaterials and further processing of medical devices is still challenging. For instance, titanium(IV) oxide is a well-established biocompatible material, and the synthesis of TiO<sub>x</sub> particles and coatings via the sol-gel process has frequently been published. However, synthesis protocols of sol-gel-derived TiO<sub>x</sub> fibers are hardly known. In this publication, the authors present a synthesis and fabrication of purely sol-gel-derived TiO<sub>x</sub> fiber fleeces starting from the liquid sol-gel precursor titanium ethylate (TEOT). Here, the <i>α</i>-hydroxy-carboxylic acid lactic acid (LA) was used as a chelating ligand to reduce the reactivity towards hydrolysis of TEOT enabling a spinnable sol. The resulting fibers were processed into a non-woven fleece, characterized with FTIR, <sup>13</sup>C-MAS-NMR, XRD, and screened with regard to their stability in physiological solution. They revealed an unexpected dependency between the LA content and the dissolution behavior. Finally, in vitro cell culture experiments proved their potential suitability as an open-mesh structured scaffold material, even for challenging applications such as therapeutic medicinal products (ATMPs).https://www.mdpi.com/1996-1944/15/8/2752sol-gel chemistryscaffolddry spinning |
| spellingShingle | Bastian Christ Walther Glaubitt Katrin Berberich Tobias Weigel Jörn Probst Gerhard Sextl Sofia Dembski Sol-Gel-Derived Fibers Based on Amorphous <i>α</i>-Hydroxy-Carboxylate-Modified Titanium(IV) Oxide as a 3-Dimensional Scaffold Materials sol-gel chemistry scaffold dry spinning |
| title | Sol-Gel-Derived Fibers Based on Amorphous <i>α</i>-Hydroxy-Carboxylate-Modified Titanium(IV) Oxide as a 3-Dimensional Scaffold |
| title_full | Sol-Gel-Derived Fibers Based on Amorphous <i>α</i>-Hydroxy-Carboxylate-Modified Titanium(IV) Oxide as a 3-Dimensional Scaffold |
| title_fullStr | Sol-Gel-Derived Fibers Based on Amorphous <i>α</i>-Hydroxy-Carboxylate-Modified Titanium(IV) Oxide as a 3-Dimensional Scaffold |
| title_full_unstemmed | Sol-Gel-Derived Fibers Based on Amorphous <i>α</i>-Hydroxy-Carboxylate-Modified Titanium(IV) Oxide as a 3-Dimensional Scaffold |
| title_short | Sol-Gel-Derived Fibers Based on Amorphous <i>α</i>-Hydroxy-Carboxylate-Modified Titanium(IV) Oxide as a 3-Dimensional Scaffold |
| title_sort | sol gel derived fibers based on amorphous i α i hydroxy carboxylate modified titanium iv oxide as a 3 dimensional scaffold |
| topic | sol-gel chemistry scaffold dry spinning |
| url | https://www.mdpi.com/1996-1944/15/8/2752 |
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