A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice
Located in the midbrain, the inferior colliculus (IC) is the hub of the central auditory system. Although the IC plays important roles in speech processing, sound localization, and other auditory computations, the organization of the IC microcircuitry remains largely unknown. Using a multifaceted ap...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-04-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/43770 |
| _version_ | 1811200036471570432 |
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| author | David Goyer Marina A Silveira Alexander P George Nichole L Beebe Ryan M Edelbrock Peter T Malinski Brett R Schofield Michael T Roberts |
| author_facet | David Goyer Marina A Silveira Alexander P George Nichole L Beebe Ryan M Edelbrock Peter T Malinski Brett R Schofield Michael T Roberts |
| author_sort | David Goyer |
| collection | DOAJ |
| description | Located in the midbrain, the inferior colliculus (IC) is the hub of the central auditory system. Although the IC plays important roles in speech processing, sound localization, and other auditory computations, the organization of the IC microcircuitry remains largely unknown. Using a multifaceted approach in mice, we have identified vasoactive intestinal peptide (VIP) neurons as a novel class of IC principal neurons. VIP neurons are glutamatergic stellate cells with sustained firing patterns. Their extensive axons project to long-range targets including the auditory thalamus, auditory brainstem, superior colliculus, and periaqueductal gray. Using optogenetic circuit mapping, we found that VIP neurons integrate input from the contralateral IC and the dorsal cochlear nucleus. The dorsal cochlear nucleus also drove feedforward inhibition to VIP neurons, indicating that inhibitory circuits within the IC shape the temporal integration of ascending inputs. Thus, VIP neurons are well-positioned to influence auditory computations in a number of brain regions. |
| first_indexed | 2024-04-12T01:58:01Z |
| format | Article |
| id | doaj.art-672f590527af4c7295ad0010648aa36b |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:58:01Z |
| publishDate | 2019-04-01 |
| publisher | eLife Sciences Publications Ltd |
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| series | eLife |
| spelling | doaj.art-672f590527af4c7295ad0010648aa36b2022-12-22T03:52:45ZengeLife Sciences Publications LtdeLife2050-084X2019-04-01810.7554/eLife.43770A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre miceDavid Goyer0https://orcid.org/0000-0001-7547-8285Marina A Silveira1Alexander P George2Nichole L Beebe3Ryan M Edelbrock4Peter T Malinski5Brett R Schofield6https://orcid.org/0000-0002-0875-7759Michael T Roberts7https://orcid.org/0000-0003-2835-8752Kresge Hearing Research Institute, Department of Otolaryngology – Head and Neck Surgery, University of Michigan, Ann Arbor, United StatesKresge Hearing Research Institute, Department of Otolaryngology – Head and Neck Surgery, University of Michigan, Ann Arbor, United StatesKresge Hearing Research Institute, Department of Otolaryngology – Head and Neck Surgery, University of Michigan, Ann Arbor, United StatesDepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, United StatesDepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, United StatesKresge Hearing Research Institute, Department of Otolaryngology – Head and Neck Surgery, University of Michigan, Ann Arbor, United StatesDepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, United StatesKresge Hearing Research Institute, Department of Otolaryngology – Head and Neck Surgery, University of Michigan, Ann Arbor, United StatesLocated in the midbrain, the inferior colliculus (IC) is the hub of the central auditory system. Although the IC plays important roles in speech processing, sound localization, and other auditory computations, the organization of the IC microcircuitry remains largely unknown. Using a multifaceted approach in mice, we have identified vasoactive intestinal peptide (VIP) neurons as a novel class of IC principal neurons. VIP neurons are glutamatergic stellate cells with sustained firing patterns. Their extensive axons project to long-range targets including the auditory thalamus, auditory brainstem, superior colliculus, and periaqueductal gray. Using optogenetic circuit mapping, we found that VIP neurons integrate input from the contralateral IC and the dorsal cochlear nucleus. The dorsal cochlear nucleus also drove feedforward inhibition to VIP neurons, indicating that inhibitory circuits within the IC shape the temporal integration of ascending inputs. Thus, VIP neurons are well-positioned to influence auditory computations in a number of brain regions.https://elifesciences.org/articles/43770auditoryneuron typesinferior colliculusVIPoptogeneticsneural circuits |
| spellingShingle | David Goyer Marina A Silveira Alexander P George Nichole L Beebe Ryan M Edelbrock Peter T Malinski Brett R Schofield Michael T Roberts A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice eLife auditory neuron types inferior colliculus VIP optogenetics neural circuits |
| title | A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice |
| title_full | A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice |
| title_fullStr | A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice |
| title_full_unstemmed | A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice |
| title_short | A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice |
| title_sort | novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide cre mice |
| topic | auditory neuron types inferior colliculus VIP optogenetics neural circuits |
| url | https://elifesciences.org/articles/43770 |
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