Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure
The increased generation of reactive oxygen species (ROS) by mitochondria under stress conditions leads to lipid peroxidation (LPO) as a consequence of the ROS interactions with polyunsaturated fatty acids in the lipid bilayer of cell membranes, causing their damage. It was assumed that chemical pre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/17/13172 |
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| author | Irina V. Zhigacheva Irina F. Rusina Natalia I. Krikunova Aleksandr N. Goloschapov Timur L. Veprintsev Olga I. Yablonskaya Aleksei V. Trofimov |
| author_facet | Irina V. Zhigacheva Irina F. Rusina Natalia I. Krikunova Aleksandr N. Goloschapov Timur L. Veprintsev Olga I. Yablonskaya Aleksei V. Trofimov |
| author_sort | Irina V. Zhigacheva |
| collection | DOAJ |
| description | The increased generation of reactive oxygen species (ROS) by mitochondria under stress conditions leads to lipid peroxidation (LPO) as a consequence of the ROS interactions with polyunsaturated fatty acids in the lipid bilayer of cell membranes, causing their damage. It was assumed that chemical preparations that reduce the excessive ROS generation by mitochondria should exhibit protecting properties under oxidative-stress conditions. In this context, the antioxidants resveratrol (RSV) and 2-ethyl-6-methyl-3-hydroxypyridine N-acetylcysteinate (NAC-3-HP) were examined as potential chemical protectors upon the exposure to stress, able to maintain the functional state of mitochondria. |
| first_indexed | 2024-03-10T23:22:33Z |
| format | Article |
| id | doaj.art-672fddf2216c4980be517e4af45b2087 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:22:33Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-672fddf2216c4980be517e4af45b20872023-11-19T08:13:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124171317210.3390/ijms241713172Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress ExposureIrina V. Zhigacheva0Irina F. Rusina1Natalia I. Krikunova2Aleksandr N. Goloschapov3Timur L. Veprintsev4Olga I. Yablonskaya5Aleksei V. Trofimov6Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, RussiaN.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, RussiaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, RussiaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, RussiaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, RussiaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, RussiaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, RussiaThe increased generation of reactive oxygen species (ROS) by mitochondria under stress conditions leads to lipid peroxidation (LPO) as a consequence of the ROS interactions with polyunsaturated fatty acids in the lipid bilayer of cell membranes, causing their damage. It was assumed that chemical preparations that reduce the excessive ROS generation by mitochondria should exhibit protecting properties under oxidative-stress conditions. In this context, the antioxidants resveratrol (RSV) and 2-ethyl-6-methyl-3-hydroxypyridine N-acetylcysteinate (NAC-3-HP) were examined as potential chemical protectors upon the exposure to stress, able to maintain the functional state of mitochondria.https://www.mdpi.com/1422-0067/24/17/13172oxidative stressROS generation and scavengingbioantioxidantsmitochondriachemiluminescence assayresveratrol |
| spellingShingle | Irina V. Zhigacheva Irina F. Rusina Natalia I. Krikunova Aleksandr N. Goloschapov Timur L. Veprintsev Olga I. Yablonskaya Aleksei V. Trofimov Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure International Journal of Molecular Sciences oxidative stress ROS generation and scavenging bioantioxidants mitochondria chemiluminescence assay resveratrol |
| title | Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure |
| title_full | Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure |
| title_fullStr | Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure |
| title_full_unstemmed | Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure |
| title_short | Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure |
| title_sort | resveratrol and 2 ethyl 6 methyl 3 hydroxypiridine n acetyl cysteinate as protecting agents upon the stress exposure |
| topic | oxidative stress ROS generation and scavenging bioantioxidants mitochondria chemiluminescence assay resveratrol |
| url | https://www.mdpi.com/1422-0067/24/17/13172 |
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