Comparision effects of solifenacin, darifenacin, propiverine on ocular parameters in eyes: A prospective study
ABSTRACT Objective To evaluate the effects of solifenacin, darifenacin, and propiverine on nasal-, subfoveal-, temporal choroidal thicknesses (NCT, SFCT, TCT), intraocular pressure (IOP) and pupil diameter (PD). Materials and Methods Patients with overactive bladder (OAB) diagnosed according to...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2020-02-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382020000200185&tlng=en |
| _version_ | 1819282463811174400 |
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| author | Mahmut Taha Ölçücü Kerem Teke Kadir Yildirim Mesut Toğaç Burcu Işık Yusuf Cem Yilmaz |
| author_facet | Mahmut Taha Ölçücü Kerem Teke Kadir Yildirim Mesut Toğaç Burcu Işık Yusuf Cem Yilmaz |
| author_sort | Mahmut Taha Ölçücü |
| collection | DOAJ |
| description | ABSTRACT Objective To evaluate the effects of solifenacin, darifenacin, and propiverine on nasal-, subfoveal-, temporal choroidal thicknesses (NCT, SFCT, TCT), intraocular pressure (IOP) and pupil diameter (PD). Materials and Methods Patients with overactive bladder (OAB) diagnosed according to The International Continence Society were administered with solifenacin, darifenacin or propiverine on a daily basis between November 2017 and May 2018. NCT, SFCT, TCT, IOP, and PD of these patients were measured and compared as initial, fourth and twelfth weeks. Results A total of 165 patients (330 eyes) with OAB were evaluated. Solifenacin (n=140) significantly reduced IOP from 17.30±2.72 mmHg to 16.67±2.56 mmHg (p=0.006) and 16.57±2.41 mmHg (p=0.002), at the fourth and twelfth weeks, respectively. Darifenacin (n=110) significantly reduced NCT from 258.70±23.96 μm to 257.51±22.66 μm (p=0.002) and 255.36±19.69 μm (p=0.038), at the fourth and twelfth weeks, respectively. Propiverine (n=80) significantly increased PD from 4.04±0.48 mm to 4.08±0.44 mm (p=0.009) and 4.09±0.45 mm (p=0.001), at the fourth and twelfth weeks, respectively. Conclusion These findings can help to decide appropriate anticholinergic drug choice in OAB patients. We finally suggest further well-designed randomized prospective studies with a larger population to evaluate the anticholinergic-related complications in eyes. |
| first_indexed | 2024-12-24T01:16:00Z |
| format | Article |
| id | doaj.art-673184f594374c33a48ac91cf472d79c |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-12-24T01:16:00Z |
| publishDate | 2020-02-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-673184f594374c33a48ac91cf472d79c2022-12-21T17:22:46ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192020-02-0146218519310.1590/s1677-5538.ibju.2019.0094Comparision effects of solifenacin, darifenacin, propiverine on ocular parameters in eyes: A prospective studyMahmut Taha Ölçücühttps://orcid.org/0000-0002-4721-2807Kerem TekeKadir YildirimMesut ToğaçBurcu IşıkYusuf Cem YilmazABSTRACT Objective To evaluate the effects of solifenacin, darifenacin, and propiverine on nasal-, subfoveal-, temporal choroidal thicknesses (NCT, SFCT, TCT), intraocular pressure (IOP) and pupil diameter (PD). Materials and Methods Patients with overactive bladder (OAB) diagnosed according to The International Continence Society were administered with solifenacin, darifenacin or propiverine on a daily basis between November 2017 and May 2018. NCT, SFCT, TCT, IOP, and PD of these patients were measured and compared as initial, fourth and twelfth weeks. Results A total of 165 patients (330 eyes) with OAB were evaluated. Solifenacin (n=140) significantly reduced IOP from 17.30±2.72 mmHg to 16.67±2.56 mmHg (p=0.006) and 16.57±2.41 mmHg (p=0.002), at the fourth and twelfth weeks, respectively. Darifenacin (n=110) significantly reduced NCT from 258.70±23.96 μm to 257.51±22.66 μm (p=0.002) and 255.36±19.69 μm (p=0.038), at the fourth and twelfth weeks, respectively. Propiverine (n=80) significantly increased PD from 4.04±0.48 mm to 4.08±0.44 mm (p=0.009) and 4.09±0.45 mm (p=0.001), at the fourth and twelfth weeks, respectively. Conclusion These findings can help to decide appropriate anticholinergic drug choice in OAB patients. We finally suggest further well-designed randomized prospective studies with a larger population to evaluate the anticholinergic-related complications in eyes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382020000200185&tlng=enPressureUrinary BladderOveractiveAnisocoria |
| spellingShingle | Mahmut Taha Ölçücü Kerem Teke Kadir Yildirim Mesut Toğaç Burcu Işık Yusuf Cem Yilmaz Comparision effects of solifenacin, darifenacin, propiverine on ocular parameters in eyes: A prospective study International Brazilian Journal of Urology Pressure Urinary Bladder Overactive Anisocoria |
| title | Comparision effects of solifenacin, darifenacin, propiverine on ocular parameters in eyes: A prospective study |
| title_full | Comparision effects of solifenacin, darifenacin, propiverine on ocular parameters in eyes: A prospective study |
| title_fullStr | Comparision effects of solifenacin, darifenacin, propiverine on ocular parameters in eyes: A prospective study |
| title_full_unstemmed | Comparision effects of solifenacin, darifenacin, propiverine on ocular parameters in eyes: A prospective study |
| title_short | Comparision effects of solifenacin, darifenacin, propiverine on ocular parameters in eyes: A prospective study |
| title_sort | comparision effects of solifenacin darifenacin propiverine on ocular parameters in eyes a prospective study |
| topic | Pressure Urinary Bladder Overactive Anisocoria |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382020000200185&tlng=en |
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