Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance
Caffeine may reduce cardiovascular disease risk, but the underlying mechanisms for these effects are incompletely understood. Here the authors report that caffeine inhibits the activation of the transcription factor SREBP2 to promote LDLc clearance through the PCSK9-LDLR axis.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28240-9 |
| _version_ | 1819274295347511296 |
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| author | Paul F. Lebeau Jae Hyun Byun Khrystyna Platko Paul Saliba Matthew Sguazzin Melissa E. MacDonald Guillaume Paré Gregory R. Steinberg Luke J. Janssen Suleiman A. Igdoura Mark A. Tarnopolsky S. R. Wayne Chen Nabil G. Seidah Jakob Magolan Richard C. Austin |
| author_facet | Paul F. Lebeau Jae Hyun Byun Khrystyna Platko Paul Saliba Matthew Sguazzin Melissa E. MacDonald Guillaume Paré Gregory R. Steinberg Luke J. Janssen Suleiman A. Igdoura Mark A. Tarnopolsky S. R. Wayne Chen Nabil G. Seidah Jakob Magolan Richard C. Austin |
| author_sort | Paul F. Lebeau |
| collection | DOAJ |
| description | Caffeine may reduce cardiovascular disease risk, but the underlying mechanisms for these effects are incompletely understood. Here the authors report that caffeine inhibits the activation of the transcription factor SREBP2 to promote LDLc clearance through the PCSK9-LDLR axis. |
| first_indexed | 2024-12-23T23:06:09Z |
| format | Article |
| id | doaj.art-6733f73670aa4d5a807867eed2c293ea |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T23:06:09Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6733f73670aa4d5a807867eed2c293ea2022-12-21T17:26:48ZengNature PortfolioNature Communications2041-17232022-02-0113111710.1038/s41467-022-28240-9Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearancePaul F. Lebeau0Jae Hyun Byun1Khrystyna Platko2Paul Saliba3Matthew Sguazzin4Melissa E. MacDonald5Guillaume Paré6Gregory R. Steinberg7Luke J. Janssen8Suleiman A. Igdoura9Mark A. Tarnopolsky10S. R. Wayne Chen11Nabil G. Seidah12Jakob Magolan13Richard C. Austin14Department of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe’s Hamilton and the Hamilton Center for Kidney ResearchDepartment of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe’s Hamilton and the Hamilton Center for Kidney ResearchDepartment of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe’s Hamilton and the Hamilton Center for Kidney ResearchDepartment of Biochemistry and Biomedical Sciences, McMaster UniversityDepartment of Biochemistry and Biomedical Sciences, McMaster UniversityDepartment of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe’s Hamilton and the Hamilton Center for Kidney ResearchPopulation Health Research Institute, McMaster UniversityDepartment of Biochemistry and Biomedical Sciences, McMaster UniversityFirestone Institute for Respiratory Health, St. Joseph’s HospitalDepartment of Biology and Pathology, McMaster UniversityDepartment of Medicine/Neurology, McMaster UniversityLibin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of CalgaryLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, affiliated to the University of MontrealDepartment of Biochemistry and Biomedical Sciences, McMaster UniversityDepartment of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe’s Hamilton and the Hamilton Center for Kidney ResearchCaffeine may reduce cardiovascular disease risk, but the underlying mechanisms for these effects are incompletely understood. Here the authors report that caffeine inhibits the activation of the transcription factor SREBP2 to promote LDLc clearance through the PCSK9-LDLR axis.https://doi.org/10.1038/s41467-022-28240-9 |
| spellingShingle | Paul F. Lebeau Jae Hyun Byun Khrystyna Platko Paul Saliba Matthew Sguazzin Melissa E. MacDonald Guillaume Paré Gregory R. Steinberg Luke J. Janssen Suleiman A. Igdoura Mark A. Tarnopolsky S. R. Wayne Chen Nabil G. Seidah Jakob Magolan Richard C. Austin Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance Nature Communications |
| title | Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance |
| title_full | Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance |
| title_fullStr | Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance |
| title_full_unstemmed | Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance |
| title_short | Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance |
| title_sort | caffeine blocks srebp2 induced hepatic pcsk9 expression to enhance ldlr mediated cholesterol clearance |
| url | https://doi.org/10.1038/s41467-022-28240-9 |
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