Application of High-Resolution Terahertz Gas Spectroscopy for Studying the Composition of Thermal Decomposition Products in Human Urine of Prostate Cancer Patients
The results of using nonstationary high-resolution THz spectroscopy for detecting a characteristic set of metabolites of thermal decomposition products of urine from prostate cancer patients, aimed at identifying specific markers, are presented. Studies of the composition of biological fluid in pros...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/14/5/1955 |
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| author | Vladimir Vaks Elena Domracheva Maria Chernyaeva Vladimir Anfertev Anna Maslennikova Vagif Atduev Kurban Atduev Mikhail Rodionov |
| author_facet | Vladimir Vaks Elena Domracheva Maria Chernyaeva Vladimir Anfertev Anna Maslennikova Vagif Atduev Kurban Atduev Mikhail Rodionov |
| author_sort | Vladimir Vaks |
| collection | DOAJ |
| description | The results of using nonstationary high-resolution THz spectroscopy for detecting a characteristic set of metabolites of thermal decomposition products of urine from prostate cancer patients, aimed at identifying specific markers, are presented. Studies of the composition of biological fluid in prostate cancer were carried out using 12 urine samples from cancer patients and 4 samples from conditionally healthy volunteers. Differences in the composition and content of substances in the urine samples of cancer patients compared to the urine of conditionally healthy volunteers were identified, which allows preliminary conclusions to be drawn about substances promising for use as markers of prostate cancer in urine. The presented approach is promising for developing a method for noninvasive study of the composition of biological fluids, which makes it possible to identify metabolite markers of various pathologies and diseases. |
| first_indexed | 2024-04-25T00:35:25Z |
| format | Article |
| id | doaj.art-6736b9ad39854bf590d9f9a7d207d2a2 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-04-25T00:35:25Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-6736b9ad39854bf590d9f9a7d207d2a22024-03-12T16:39:35ZengMDPI AGApplied Sciences2076-34172024-02-01145195510.3390/app14051955Application of High-Resolution Terahertz Gas Spectroscopy for Studying the Composition of Thermal Decomposition Products in Human Urine of Prostate Cancer PatientsVladimir Vaks0Elena Domracheva1Maria Chernyaeva2Vladimir Anfertev3Anna Maslennikova4Vagif Atduev5Kurban Atduev6Mikhail Rodionov7Institute for Physics of Microstructures of Russian Academy of Sciences, Nizhny Novgorod 603087, RussiaInstitute for Physics of Microstructures of Russian Academy of Sciences, Nizhny Novgorod 603087, RussiaInstitute for Physics of Microstructures of Russian Academy of Sciences, Nizhny Novgorod 603087, RussiaInstitute for Physics of Microstructures of Russian Academy of Sciences, Nizhny Novgorod 603087, RussiaInstitute of Biology and Biomedicine, Lobachevsky State University, Nizhny Novgorod 603022, RussiaDepartment of Faculty Surgery and Transplantation, Privolzhsky Research Medical University, Nizhny Novgorod 603005, RussiaDepartment of Oncology, Radiation Therapy and Radiation Diagnostics, Privolzhsky Research Medical University, Nizhny Novgorod 603005, RussiaInstitute for Physics of Microstructures of Russian Academy of Sciences, Nizhny Novgorod 603087, RussiaThe results of using nonstationary high-resolution THz spectroscopy for detecting a characteristic set of metabolites of thermal decomposition products of urine from prostate cancer patients, aimed at identifying specific markers, are presented. Studies of the composition of biological fluid in prostate cancer were carried out using 12 urine samples from cancer patients and 4 samples from conditionally healthy volunteers. Differences in the composition and content of substances in the urine samples of cancer patients compared to the urine of conditionally healthy volunteers were identified, which allows preliminary conclusions to be drawn about substances promising for use as markers of prostate cancer in urine. The presented approach is promising for developing a method for noninvasive study of the composition of biological fluids, which makes it possible to identify metabolite markers of various pathologies and diseases.https://www.mdpi.com/2076-3417/14/5/1955THz high-resolution spectroscopyprostate cancerurinaprostate-specific antigenthermal decompositionmetabolite |
| spellingShingle | Vladimir Vaks Elena Domracheva Maria Chernyaeva Vladimir Anfertev Anna Maslennikova Vagif Atduev Kurban Atduev Mikhail Rodionov Application of High-Resolution Terahertz Gas Spectroscopy for Studying the Composition of Thermal Decomposition Products in Human Urine of Prostate Cancer Patients Applied Sciences THz high-resolution spectroscopy prostate cancer urina prostate-specific antigen thermal decomposition metabolite |
| title | Application of High-Resolution Terahertz Gas Spectroscopy for Studying the Composition of Thermal Decomposition Products in Human Urine of Prostate Cancer Patients |
| title_full | Application of High-Resolution Terahertz Gas Spectroscopy for Studying the Composition of Thermal Decomposition Products in Human Urine of Prostate Cancer Patients |
| title_fullStr | Application of High-Resolution Terahertz Gas Spectroscopy for Studying the Composition of Thermal Decomposition Products in Human Urine of Prostate Cancer Patients |
| title_full_unstemmed | Application of High-Resolution Terahertz Gas Spectroscopy for Studying the Composition of Thermal Decomposition Products in Human Urine of Prostate Cancer Patients |
| title_short | Application of High-Resolution Terahertz Gas Spectroscopy for Studying the Composition of Thermal Decomposition Products in Human Urine of Prostate Cancer Patients |
| title_sort | application of high resolution terahertz gas spectroscopy for studying the composition of thermal decomposition products in human urine of prostate cancer patients |
| topic | THz high-resolution spectroscopy prostate cancer urina prostate-specific antigen thermal decomposition metabolite |
| url | https://www.mdpi.com/2076-3417/14/5/1955 |
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