Heteronuclear-filtered 1H homonuclear multi-quantum correlation experiment at 100 kHz magic-angle spinning
Remarkable advances in fast magic-angle spinning (MAS) techniques significantly improve the resolution of 1H solid-state nuclear magnetic resonance (NMR) spectra. Here, we introduce a heteronuclear-filtered 1H homonuclear multi-quantum (MQ) correlation strategy available at a MAS rate of 100 kHz by...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2022-11-01
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| Series: | Magnetic Resonance Letters |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772516222000420 |
| _version_ | 1811196707922247680 |
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| author | Mingji Zheng Shuangqin Zeng Xiumei Wang Xiuzhi Gao Qiang Wang Jun Xu Feng Deng |
| author_facet | Mingji Zheng Shuangqin Zeng Xiumei Wang Xiuzhi Gao Qiang Wang Jun Xu Feng Deng |
| author_sort | Mingji Zheng |
| collection | DOAJ |
| description | Remarkable advances in fast magic-angle spinning (MAS) techniques significantly improve the resolution of 1H solid-state nuclear magnetic resonance (NMR) spectra. Here, we introduce a heteronuclear-filtered 1H homonuclear multi-quantum (MQ) correlation strategy available at a MAS rate of 100 kHz by combining 1H{X} heteronuclear-filtered methods and 1H homonuclear MQ correlation experiments. The proposed strategy was applied to selectively extract 1H signals of aluminum lactate (Al-Lac) in a mixture of Al-Lac and zinc lactate (Zn-Lac) using 27Al-filtered methods (i.e., 1H{27Al} heteronuclear multiple quantum correlation (HMQC) or 1H{27Al} symmetry-based resonance-echo saturation-pulse double-resonance (S-RESPDOR)). We demonstrate that incorporating these 27Al-filtered methods into two-dimensional (2D) 1H–1H double-quantum (DQ)/single-quantum (SQ), triple-quantum (TQ)/SQ, and even three-dimensional (3D) 27Al/1H(DQ)/1H(SQ) experiments can facilitate the acquisition of spectra without signal overlap and targeted characterization of the 1H species surrounding 27Al sites. The proposed strategy is considered to efficiently extract key structural information from complex spin systems. |
| first_indexed | 2024-04-12T01:03:31Z |
| format | Article |
| id | doaj.art-67390506dcae4e27b0ede37675fe3444 |
| institution | Directory Open Access Journal |
| issn | 2772-5162 |
| language | English |
| last_indexed | 2024-04-12T01:03:31Z |
| publishDate | 2022-11-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Magnetic Resonance Letters |
| spelling | doaj.art-67390506dcae4e27b0ede37675fe34442022-12-22T03:54:22ZengKeAi Communications Co. Ltd.Magnetic Resonance Letters2772-51622022-11-0124266275Heteronuclear-filtered 1H homonuclear multi-quantum correlation experiment at 100 kHz magic-angle spinningMingji Zheng0Shuangqin Zeng1Xiumei Wang2Xiuzhi Gao3Qiang Wang4Jun Xu5Feng Deng6State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, 430071, China; University of Chinese Academy of Sciences, Beijing, 100049, ChinaSINOPEC Research Institute of Petroleum Processing, Beijing, 100083, ChinaBruker (Beijing) Scientific Technology Co. Ltd., Beijing, 100192, ChinaSINOPEC Research Institute of Petroleum Processing, Beijing, 100083, ChinaState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, 430071, China; Corresponding author.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, 430071, China; Corresponding author.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, 430071, China; Corresponding author.Remarkable advances in fast magic-angle spinning (MAS) techniques significantly improve the resolution of 1H solid-state nuclear magnetic resonance (NMR) spectra. Here, we introduce a heteronuclear-filtered 1H homonuclear multi-quantum (MQ) correlation strategy available at a MAS rate of 100 kHz by combining 1H{X} heteronuclear-filtered methods and 1H homonuclear MQ correlation experiments. The proposed strategy was applied to selectively extract 1H signals of aluminum lactate (Al-Lac) in a mixture of Al-Lac and zinc lactate (Zn-Lac) using 27Al-filtered methods (i.e., 1H{27Al} heteronuclear multiple quantum correlation (HMQC) or 1H{27Al} symmetry-based resonance-echo saturation-pulse double-resonance (S-RESPDOR)). We demonstrate that incorporating these 27Al-filtered methods into two-dimensional (2D) 1H–1H double-quantum (DQ)/single-quantum (SQ), triple-quantum (TQ)/SQ, and even three-dimensional (3D) 27Al/1H(DQ)/1H(SQ) experiments can facilitate the acquisition of spectra without signal overlap and targeted characterization of the 1H species surrounding 27Al sites. The proposed strategy is considered to efficiently extract key structural information from complex spin systems.http://www.sciencedirect.com/science/article/pii/S2772516222000420Solid-state NMR spectroscopyProtonHeteronuclear filterHomonuclear correlationMulti-quantumUltra-fast magic angle spinning |
| spellingShingle | Mingji Zheng Shuangqin Zeng Xiumei Wang Xiuzhi Gao Qiang Wang Jun Xu Feng Deng Heteronuclear-filtered 1H homonuclear multi-quantum correlation experiment at 100 kHz magic-angle spinning Magnetic Resonance Letters Solid-state NMR spectroscopy Proton Heteronuclear filter Homonuclear correlation Multi-quantum Ultra-fast magic angle spinning |
| title | Heteronuclear-filtered 1H homonuclear multi-quantum correlation experiment at 100 kHz magic-angle spinning |
| title_full | Heteronuclear-filtered 1H homonuclear multi-quantum correlation experiment at 100 kHz magic-angle spinning |
| title_fullStr | Heteronuclear-filtered 1H homonuclear multi-quantum correlation experiment at 100 kHz magic-angle spinning |
| title_full_unstemmed | Heteronuclear-filtered 1H homonuclear multi-quantum correlation experiment at 100 kHz magic-angle spinning |
| title_short | Heteronuclear-filtered 1H homonuclear multi-quantum correlation experiment at 100 kHz magic-angle spinning |
| title_sort | heteronuclear filtered 1h homonuclear multi quantum correlation experiment at 100 khz magic angle spinning |
| topic | Solid-state NMR spectroscopy Proton Heteronuclear filter Homonuclear correlation Multi-quantum Ultra-fast magic angle spinning |
| url | http://www.sciencedirect.com/science/article/pii/S2772516222000420 |
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