Treatment of Laryngeal Verrucous Carcinoma: 28‐Year Retrospective Cohort Study and Literature Review
Abstract Objective Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. Although controversial, surgery has been the mainstay of treatment, due to concern about anaplastic transformation with radiotherapy. We aimed to study LVC patients to identify treatment patterns for p...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-04-01
|
| Series: | OTO Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/oto2.50 |
| _version_ | 1797537458339971072 |
|---|---|
| author | Ameen Amanian Donald W. Anderson James Scott Durham Eitan Prisman Tony Ng Amanda Hu |
| author_facet | Ameen Amanian Donald W. Anderson James Scott Durham Eitan Prisman Tony Ng Amanda Hu |
| author_sort | Ameen Amanian |
| collection | DOAJ |
| description | Abstract Objective Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. Although controversial, surgery has been the mainstay of treatment, due to concern about anaplastic transformation with radiotherapy. We aimed to study LVC patients to identify treatment patterns for primary and recurrent diseases. Study Design Retrospective cohort study. Setting Tertiary referral center. Methods Patients with a pathological diagnosis of LVC treated over a 28‐year period were included. Baseline demographics, and treatment outcome measures including 5‐year laryngeal preservation rates (LPR), overall survival (OS), and recurrence‐free survival (RFS) were included. A literature review of published studies within the same study period was also completed. Results Thirty‐two patients were included in the analysis (median age 61.5 years, 93.8% [30/32] male). Twenty‐three patients had T1 disease, and 9 had T2 disease with no evidence of regional or metastatic disease. The most common presenting symptom was hoarseness (93.8%) and the majority within the glottis 81.3% (26/32). Twenty‐nine patients underwent primary surgery only (28 local excisions, 1 vertical partial laryngectomy) meanwhile 3 underwent local excision with postoperative radiotherapy. LPR, OS, and RFS at 5 years were 95.8%, 90.1%, and 80.6%, respectively. Our literature review identified 23 previous studies, mostly single‐institution retrospective case series. Our study was the largest Canadian study in the literature to date. Conclusion All LVC patients were treated with primary surgery, consistent with the current literature with excellent 5‐year OS and LPR. There was no consensus on the treatment of recurrent disease. Future prospective multicenter studies are warranted to further study this rare disease population. |
| first_indexed | 2024-03-10T12:16:25Z |
| format | Article |
| id | doaj.art-6739182ba96d4cd0929e67025206e4ef |
| institution | Directory Open Access Journal |
| issn | 2473-974X |
| language | English |
| last_indexed | 2024-03-10T12:16:25Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | OTO Open |
| spelling | doaj.art-6739182ba96d4cd0929e67025206e4ef2023-11-21T15:50:22ZengWileyOTO Open2473-974X2023-04-0172n/an/a10.1002/oto2.50Treatment of Laryngeal Verrucous Carcinoma: 28‐Year Retrospective Cohort Study and Literature ReviewAmeen Amanian0Donald W. Anderson1James Scott Durham2Eitan Prisman3Tony Ng4Amanda Hu5Division of Otolaryngology–Head and Neck Surgery, Department of Surgery University of British Columbia Vancouver CanadaDivision of Otolaryngology–Head and Neck Surgery, Department of Surgery University of British Columbia Vancouver CanadaDivision of Otolaryngology–Head and Neck Surgery, Department of Surgery University of British Columbia Vancouver CanadaDivision of Otolaryngology–Head and Neck Surgery, Department of Surgery University of British Columbia Vancouver CanadaDepartment of Pathology and Laboratory Medicine University of British Columbia Vancouver CanadaDivision of Otolaryngology–Head and Neck Surgery, Department of Surgery University of British Columbia Vancouver CanadaAbstract Objective Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. Although controversial, surgery has been the mainstay of treatment, due to concern about anaplastic transformation with radiotherapy. We aimed to study LVC patients to identify treatment patterns for primary and recurrent diseases. Study Design Retrospective cohort study. Setting Tertiary referral center. Methods Patients with a pathological diagnosis of LVC treated over a 28‐year period were included. Baseline demographics, and treatment outcome measures including 5‐year laryngeal preservation rates (LPR), overall survival (OS), and recurrence‐free survival (RFS) were included. A literature review of published studies within the same study period was also completed. Results Thirty‐two patients were included in the analysis (median age 61.5 years, 93.8% [30/32] male). Twenty‐three patients had T1 disease, and 9 had T2 disease with no evidence of regional or metastatic disease. The most common presenting symptom was hoarseness (93.8%) and the majority within the glottis 81.3% (26/32). Twenty‐nine patients underwent primary surgery only (28 local excisions, 1 vertical partial laryngectomy) meanwhile 3 underwent local excision with postoperative radiotherapy. LPR, OS, and RFS at 5 years were 95.8%, 90.1%, and 80.6%, respectively. Our literature review identified 23 previous studies, mostly single‐institution retrospective case series. Our study was the largest Canadian study in the literature to date. Conclusion All LVC patients were treated with primary surgery, consistent with the current literature with excellent 5‐year OS and LPR. There was no consensus on the treatment of recurrent disease. Future prospective multicenter studies are warranted to further study this rare disease population.https://doi.org/10.1002/oto2.50Ackerman's tumorlaryngeal cancerlaryngeal surgerylaryngeal verrucous carcinomaradiotherapysurvival analysis |
| spellingShingle | Ameen Amanian Donald W. Anderson James Scott Durham Eitan Prisman Tony Ng Amanda Hu Treatment of Laryngeal Verrucous Carcinoma: 28‐Year Retrospective Cohort Study and Literature Review OTO Open Ackerman's tumor laryngeal cancer laryngeal surgery laryngeal verrucous carcinoma radiotherapy survival analysis |
| title | Treatment of Laryngeal Verrucous Carcinoma: 28‐Year Retrospective Cohort Study and Literature Review |
| title_full | Treatment of Laryngeal Verrucous Carcinoma: 28‐Year Retrospective Cohort Study and Literature Review |
| title_fullStr | Treatment of Laryngeal Verrucous Carcinoma: 28‐Year Retrospective Cohort Study and Literature Review |
| title_full_unstemmed | Treatment of Laryngeal Verrucous Carcinoma: 28‐Year Retrospective Cohort Study and Literature Review |
| title_short | Treatment of Laryngeal Verrucous Carcinoma: 28‐Year Retrospective Cohort Study and Literature Review |
| title_sort | treatment of laryngeal verrucous carcinoma 28 year retrospective cohort study and literature review |
| topic | Ackerman's tumor laryngeal cancer laryngeal surgery laryngeal verrucous carcinoma radiotherapy survival analysis |
| url | https://doi.org/10.1002/oto2.50 |
| work_keys_str_mv | AT ameenamanian treatmentoflaryngealverrucouscarcinoma28yearretrospectivecohortstudyandliteraturereview AT donaldwanderson treatmentoflaryngealverrucouscarcinoma28yearretrospectivecohortstudyandliteraturereview AT jamesscottdurham treatmentoflaryngealverrucouscarcinoma28yearretrospectivecohortstudyandliteraturereview AT eitanprisman treatmentoflaryngealverrucouscarcinoma28yearretrospectivecohortstudyandliteraturereview AT tonyng treatmentoflaryngealverrucouscarcinoma28yearretrospectivecohortstudyandliteraturereview AT amandahu treatmentoflaryngealverrucouscarcinoma28yearretrospectivecohortstudyandliteraturereview |