Biomimetic Enamel Regeneration Using Self-Assembling Peptide P<sub>11</sub>-4
The recent understanding of the etiology and pathology of dental caries has shifted its treatment from invasive drill and fill conventional strategies to noninvasive and/or minimally invasive approaches. Guided tissue regeneration (GTR) is a well-established therapeutic approach in medicine and peri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Biomimetics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2313-7673/8/3/290 |
| _version_ | 1797590099181961216 |
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| author | Mohammad Alkilzy Ghalib Qadri Christian H. Splieth Ruth M. Santamaría |
| author_facet | Mohammad Alkilzy Ghalib Qadri Christian H. Splieth Ruth M. Santamaría |
| author_sort | Mohammad Alkilzy |
| collection | DOAJ |
| description | The recent understanding of the etiology and pathology of dental caries has shifted its treatment from invasive drill and fill conventional strategies to noninvasive and/or minimally invasive approaches. Guided tissue regeneration (GTR) is a well-established therapeutic approach in medicine and periodontal and oral surgery. Recently, the concept of biomimetic regeneration has been further expanded to treat the loss of hard dental tissues. Self-assembling peptides have emerged as a promising biomaterial for biomimetic regeneration due to their ability to construct a protein scaffold in the body of early carious lesions and provide a matrix that promotes remineralization. This review article accompanies the development of self-assembling peptide P<sub>11</sub>-4 for the treatment of initial carious lesions. In vitro and in vivo studies on the safety, clinical applicability, and efficacy of P<sub>11</sub>-4 are discussed. Furthermore, different treatment options and potential areas of application are presented. |
| first_indexed | 2024-03-11T01:15:37Z |
| format | Article |
| id | doaj.art-6739c1864a6e4326a4768cc833803783 |
| institution | Directory Open Access Journal |
| issn | 2313-7673 |
| language | English |
| last_indexed | 2024-03-11T01:15:37Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj.art-6739c1864a6e4326a4768cc8338037832023-11-18T18:29:39ZengMDPI AGBiomimetics2313-76732023-07-018329010.3390/biomimetics8030290Biomimetic Enamel Regeneration Using Self-Assembling Peptide P<sub>11</sub>-4Mohammad Alkilzy0Ghalib Qadri1Christian H. Splieth2Ruth M. Santamaría3Department of Preventive and Pediatric Dentistry, University of Greifswald, 17475 Greifswald, GermanyDepartment of Orthodontic and Pediatric Dentistry, Arab American University, Jenin P.O. Box 240, PalestineDepartment of Preventive and Pediatric Dentistry, University of Greifswald, 17475 Greifswald, GermanyDepartment of Preventive and Pediatric Dentistry, University of Greifswald, 17475 Greifswald, GermanyThe recent understanding of the etiology and pathology of dental caries has shifted its treatment from invasive drill and fill conventional strategies to noninvasive and/or minimally invasive approaches. Guided tissue regeneration (GTR) is a well-established therapeutic approach in medicine and periodontal and oral surgery. Recently, the concept of biomimetic regeneration has been further expanded to treat the loss of hard dental tissues. Self-assembling peptides have emerged as a promising biomaterial for biomimetic regeneration due to their ability to construct a protein scaffold in the body of early carious lesions and provide a matrix that promotes remineralization. This review article accompanies the development of self-assembling peptide P<sub>11</sub>-4 for the treatment of initial carious lesions. In vitro and in vivo studies on the safety, clinical applicability, and efficacy of P<sub>11</sub>-4 are discussed. Furthermore, different treatment options and potential areas of application are presented.https://www.mdpi.com/2313-7673/8/3/290biomimeticenamel regenerationP<sub>11</sub>-4initial cariesself-assembling peptide |
| spellingShingle | Mohammad Alkilzy Ghalib Qadri Christian H. Splieth Ruth M. Santamaría Biomimetic Enamel Regeneration Using Self-Assembling Peptide P<sub>11</sub>-4 Biomimetics biomimetic enamel regeneration P<sub>11</sub>-4 initial caries self-assembling peptide |
| title | Biomimetic Enamel Regeneration Using Self-Assembling Peptide P<sub>11</sub>-4 |
| title_full | Biomimetic Enamel Regeneration Using Self-Assembling Peptide P<sub>11</sub>-4 |
| title_fullStr | Biomimetic Enamel Regeneration Using Self-Assembling Peptide P<sub>11</sub>-4 |
| title_full_unstemmed | Biomimetic Enamel Regeneration Using Self-Assembling Peptide P<sub>11</sub>-4 |
| title_short | Biomimetic Enamel Regeneration Using Self-Assembling Peptide P<sub>11</sub>-4 |
| title_sort | biomimetic enamel regeneration using self assembling peptide p sub 11 sub 4 |
| topic | biomimetic enamel regeneration P<sub>11</sub>-4 initial caries self-assembling peptide |
| url | https://www.mdpi.com/2313-7673/8/3/290 |
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