Actinobacillus pleuropneumoniae, surface proteins and virulence: a review

Actinobacillus pleuropneumoniae (App) is a globally distributed Gram-negative bacterium that produces porcine pleuropneumonia. This highly contagious disease produces high morbidity and mortality in the swine industry. However, no effective vaccine exists to prevent it. The infection caused by App p...

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Main Authors: María M. Soto Perezchica, Alma L. Guerrero Barrera, Francisco J. Avelar Gonzalez, Teodulo Quezada Tristan, Osvaldo Macias Marin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Veterinary Science
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2023.1276712/full
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author María M. Soto Perezchica
Alma L. Guerrero Barrera
Francisco J. Avelar Gonzalez
Teodulo Quezada Tristan
Osvaldo Macias Marin
author_facet María M. Soto Perezchica
Alma L. Guerrero Barrera
Francisco J. Avelar Gonzalez
Teodulo Quezada Tristan
Osvaldo Macias Marin
author_sort María M. Soto Perezchica
collection DOAJ
description Actinobacillus pleuropneumoniae (App) is a globally distributed Gram-negative bacterium that produces porcine pleuropneumonia. This highly contagious disease produces high morbidity and mortality in the swine industry. However, no effective vaccine exists to prevent it. The infection caused by App provokes characteristic lesions, such as edema, inflammation, hemorrhage, and necrosis, that involve different virulence factors. The colonization and invasion of host surfaces involved structures and proteins such as outer membrane vesicles (OMVs), pili, flagella, adhesins, outer membrane proteins (OMPs), also participates proteases, autotransporters, and lipoproteins. The recent findings on surface structures and proteins described in this review highlight them as potential immunogens for vaccine development.
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spelling doaj.art-673a068f63ab4600a8b5997dda17dc8a2023-12-01T10:24:54ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-11-011010.3389/fvets.2023.12767121276712Actinobacillus pleuropneumoniae, surface proteins and virulence: a reviewMaría M. Soto Perezchica0Alma L. Guerrero Barrera1Francisco J. Avelar Gonzalez2Teodulo Quezada Tristan3Osvaldo Macias Marin4Laboratorio de Biología Celular y Tisular, Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoLaboratorio de Biología Celular y Tisular, Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoLaboratorio de Estudios Ambientales, Departamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoDepartamento de Ciencias Veterinaria, Centro de Ciencias Agropecuarias, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoLaboratorio de Biología Celular y Tisular, Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoActinobacillus pleuropneumoniae (App) is a globally distributed Gram-negative bacterium that produces porcine pleuropneumonia. This highly contagious disease produces high morbidity and mortality in the swine industry. However, no effective vaccine exists to prevent it. The infection caused by App provokes characteristic lesions, such as edema, inflammation, hemorrhage, and necrosis, that involve different virulence factors. The colonization and invasion of host surfaces involved structures and proteins such as outer membrane vesicles (OMVs), pili, flagella, adhesins, outer membrane proteins (OMPs), also participates proteases, autotransporters, and lipoproteins. The recent findings on surface structures and proteins described in this review highlight them as potential immunogens for vaccine development.https://www.frontiersin.org/articles/10.3389/fvets.2023.1276712/fullActinobacillus pleuropneumoniaebacterial envelopemembrane proteinsproteomevaccinebiofilm
spellingShingle María M. Soto Perezchica
Alma L. Guerrero Barrera
Francisco J. Avelar Gonzalez
Teodulo Quezada Tristan
Osvaldo Macias Marin
Actinobacillus pleuropneumoniae, surface proteins and virulence: a review
Frontiers in Veterinary Science
Actinobacillus pleuropneumoniae
bacterial envelope
membrane proteins
proteome
vaccine
biofilm
title Actinobacillus pleuropneumoniae, surface proteins and virulence: a review
title_full Actinobacillus pleuropneumoniae, surface proteins and virulence: a review
title_fullStr Actinobacillus pleuropneumoniae, surface proteins and virulence: a review
title_full_unstemmed Actinobacillus pleuropneumoniae, surface proteins and virulence: a review
title_short Actinobacillus pleuropneumoniae, surface proteins and virulence: a review
title_sort actinobacillus pleuropneumoniae surface proteins and virulence a review
topic Actinobacillus pleuropneumoniae
bacterial envelope
membrane proteins
proteome
vaccine
biofilm
url https://www.frontiersin.org/articles/10.3389/fvets.2023.1276712/full
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AT teoduloquezadatristan actinobacilluspleuropneumoniaesurfaceproteinsandvirulenceareview
AT osvaldomaciasmarin actinobacilluspleuropneumoniaesurfaceproteinsandvirulenceareview