Actinobacillus pleuropneumoniae, surface proteins and virulence: a review
Actinobacillus pleuropneumoniae (App) is a globally distributed Gram-negative bacterium that produces porcine pleuropneumonia. This highly contagious disease produces high morbidity and mortality in the swine industry. However, no effective vaccine exists to prevent it. The infection caused by App p...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2023-11-01
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Series: | Frontiers in Veterinary Science |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1276712/full |
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author | María M. Soto Perezchica Alma L. Guerrero Barrera Francisco J. Avelar Gonzalez Teodulo Quezada Tristan Osvaldo Macias Marin |
author_facet | María M. Soto Perezchica Alma L. Guerrero Barrera Francisco J. Avelar Gonzalez Teodulo Quezada Tristan Osvaldo Macias Marin |
author_sort | María M. Soto Perezchica |
collection | DOAJ |
description | Actinobacillus pleuropneumoniae (App) is a globally distributed Gram-negative bacterium that produces porcine pleuropneumonia. This highly contagious disease produces high morbidity and mortality in the swine industry. However, no effective vaccine exists to prevent it. The infection caused by App provokes characteristic lesions, such as edema, inflammation, hemorrhage, and necrosis, that involve different virulence factors. The colonization and invasion of host surfaces involved structures and proteins such as outer membrane vesicles (OMVs), pili, flagella, adhesins, outer membrane proteins (OMPs), also participates proteases, autotransporters, and lipoproteins. The recent findings on surface structures and proteins described in this review highlight them as potential immunogens for vaccine development. |
first_indexed | 2024-03-09T10:45:27Z |
format | Article |
id | doaj.art-673a068f63ab4600a8b5997dda17dc8a |
institution | Directory Open Access Journal |
issn | 2297-1769 |
language | English |
last_indexed | 2024-03-09T10:45:27Z |
publishDate | 2023-11-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Veterinary Science |
spelling | doaj.art-673a068f63ab4600a8b5997dda17dc8a2023-12-01T10:24:54ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-11-011010.3389/fvets.2023.12767121276712Actinobacillus pleuropneumoniae, surface proteins and virulence: a reviewMaría M. Soto Perezchica0Alma L. Guerrero Barrera1Francisco J. Avelar Gonzalez2Teodulo Quezada Tristan3Osvaldo Macias Marin4Laboratorio de Biología Celular y Tisular, Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoLaboratorio de Biología Celular y Tisular, Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoLaboratorio de Estudios Ambientales, Departamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoDepartamento de Ciencias Veterinaria, Centro de Ciencias Agropecuarias, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoLaboratorio de Biología Celular y Tisular, Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoActinobacillus pleuropneumoniae (App) is a globally distributed Gram-negative bacterium that produces porcine pleuropneumonia. This highly contagious disease produces high morbidity and mortality in the swine industry. However, no effective vaccine exists to prevent it. The infection caused by App provokes characteristic lesions, such as edema, inflammation, hemorrhage, and necrosis, that involve different virulence factors. The colonization and invasion of host surfaces involved structures and proteins such as outer membrane vesicles (OMVs), pili, flagella, adhesins, outer membrane proteins (OMPs), also participates proteases, autotransporters, and lipoproteins. The recent findings on surface structures and proteins described in this review highlight them as potential immunogens for vaccine development.https://www.frontiersin.org/articles/10.3389/fvets.2023.1276712/fullActinobacillus pleuropneumoniaebacterial envelopemembrane proteinsproteomevaccinebiofilm |
spellingShingle | María M. Soto Perezchica Alma L. Guerrero Barrera Francisco J. Avelar Gonzalez Teodulo Quezada Tristan Osvaldo Macias Marin Actinobacillus pleuropneumoniae, surface proteins and virulence: a review Frontiers in Veterinary Science Actinobacillus pleuropneumoniae bacterial envelope membrane proteins proteome vaccine biofilm |
title | Actinobacillus pleuropneumoniae, surface proteins and virulence: a review |
title_full | Actinobacillus pleuropneumoniae, surface proteins and virulence: a review |
title_fullStr | Actinobacillus pleuropneumoniae, surface proteins and virulence: a review |
title_full_unstemmed | Actinobacillus pleuropneumoniae, surface proteins and virulence: a review |
title_short | Actinobacillus pleuropneumoniae, surface proteins and virulence: a review |
title_sort | actinobacillus pleuropneumoniae surface proteins and virulence a review |
topic | Actinobacillus pleuropneumoniae bacterial envelope membrane proteins proteome vaccine biofilm |
url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1276712/full |
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