Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats
The spontaneously hypertensive rat (SHR) is a genetic model of primary hypertension with an etiology that includes sympathetic overdrive. To elucidate the neurogenic mechanisms underlying the pathophysiology of this model, we analyzed the dynamic baroreflex response to spontaneous fluctuations in ar...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Society for Clinical investigation
2020-10-01
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| Series: | JCI Insight |
| Subjects: | |
| Online Access: | https://doi.org/10.1172/jci.insight.139789 |
| _version_ | 1818722990663139328 |
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| author | Feng Gu E. Benjamin Randall Steven Whitesall Kimber Converso-Baran Brian E. Carlson Gregory D. Fink Daniel E. Michele Daniel A. Beard |
| author_facet | Feng Gu E. Benjamin Randall Steven Whitesall Kimber Converso-Baran Brian E. Carlson Gregory D. Fink Daniel E. Michele Daniel A. Beard |
| author_sort | Feng Gu |
| collection | DOAJ |
| description | The spontaneously hypertensive rat (SHR) is a genetic model of primary hypertension with an etiology that includes sympathetic overdrive. To elucidate the neurogenic mechanisms underlying the pathophysiology of this model, we analyzed the dynamic baroreflex response to spontaneous fluctuations in arterial pressure in conscious SHRs, as well as in the Wistar-Kyoto (WKY), the Dahl salt-sensitive, the Dahl salt-resistant, and the Sprague-Dawley rat. Observations revealed the existence of long intermittent periods (lasting up to several minutes) of engagement and disengagement of baroreflex control of heart rate. Analysis of these intermittent periods revealed a predictive relationship between increased mean arterial pressure and progressive baroreflex disengagement that was present in the SHR and WKY strains but absent in others. This relationship yielded the hypothesis that a lower proportion of engagement versus disengagement of the baroreflex in SHR compared with WKY contributes to the hypertension (or increased blood pressure) in SHR compared with WKY. Results of experiments using sinoaortic baroreceptor denervation were consistent with the hypothesis that dysfunction of the baroreflex contributes to the etiology of hypertension in the SHR. Thus, this study provides experimental evidence for the roles of the baroreflex in long-term arterial pressure regulation and in the etiology of primary hypertension in this animal model. |
| first_indexed | 2024-12-17T21:03:24Z |
| format | Article |
| id | doaj.art-673ba72f27fc41bc8d642cb0753088f3 |
| institution | Directory Open Access Journal |
| issn | 2379-3708 |
| language | English |
| last_indexed | 2024-12-17T21:03:24Z |
| publishDate | 2020-10-01 |
| publisher | American Society for Clinical investigation |
| record_format | Article |
| series | JCI Insight |
| spelling | doaj.art-673ba72f27fc41bc8d642cb0753088f32022-12-21T21:32:39ZengAmerican Society for Clinical investigationJCI Insight2379-37082020-10-01519Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive ratsFeng GuE. Benjamin RandallSteven WhitesallKimber Converso-BaranBrian E. CarlsonGregory D. FinkDaniel E. MicheleDaniel A. BeardThe spontaneously hypertensive rat (SHR) is a genetic model of primary hypertension with an etiology that includes sympathetic overdrive. To elucidate the neurogenic mechanisms underlying the pathophysiology of this model, we analyzed the dynamic baroreflex response to spontaneous fluctuations in arterial pressure in conscious SHRs, as well as in the Wistar-Kyoto (WKY), the Dahl salt-sensitive, the Dahl salt-resistant, and the Sprague-Dawley rat. Observations revealed the existence of long intermittent periods (lasting up to several minutes) of engagement and disengagement of baroreflex control of heart rate. Analysis of these intermittent periods revealed a predictive relationship between increased mean arterial pressure and progressive baroreflex disengagement that was present in the SHR and WKY strains but absent in others. This relationship yielded the hypothesis that a lower proportion of engagement versus disengagement of the baroreflex in SHR compared with WKY contributes to the hypertension (or increased blood pressure) in SHR compared with WKY. Results of experiments using sinoaortic baroreceptor denervation were consistent with the hypothesis that dysfunction of the baroreflex contributes to the etiology of hypertension in the SHR. Thus, this study provides experimental evidence for the roles of the baroreflex in long-term arterial pressure regulation and in the etiology of primary hypertension in this animal model.https://doi.org/10.1172/jci.insight.139789Cardiology |
| spellingShingle | Feng Gu E. Benjamin Randall Steven Whitesall Kimber Converso-Baran Brian E. Carlson Gregory D. Fink Daniel E. Michele Daniel A. Beard Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats JCI Insight Cardiology |
| title | Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats |
| title_full | Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats |
| title_fullStr | Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats |
| title_full_unstemmed | Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats |
| title_short | Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats |
| title_sort | potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats |
| topic | Cardiology |
| url | https://doi.org/10.1172/jci.insight.139789 |
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