Fluoro-18-fluorodeoxyglucose positron emission tomography/computed tomography detects Ewing’s sarcoma of the larynx with multiple distant bone metastases: a case report and literature review
Ewing sarcomas (EWS) are highly malignant neoplasms of mesenchymal origin that are rare in the head and neck. Only a few laryngeal EWS have been reported in the literature. We report a 47 years-old man who visited our hospital for medical help after 5 months of hoarseness and sore throat. Computed t...
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1167350/full |
| _version_ | 1797787743038734336 |
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| author | Xianwen Hu Yan Liao Rui Wang Rui Wen Dandan Li Pan Wang Jiong Cai |
| author_facet | Xianwen Hu Yan Liao Rui Wang Rui Wen Dandan Li Pan Wang Jiong Cai |
| author_sort | Xianwen Hu |
| collection | DOAJ |
| description | Ewing sarcomas (EWS) are highly malignant neoplasms of mesenchymal origin that are rare in the head and neck. Only a few laryngeal EWS have been reported in the literature. We report a 47 years-old man who visited our hospital for medical help after 5 months of hoarseness and sore throat. Computed tomography (CT) showed uneven thickening of the epiglottis fold, right vocal cord, and anterior union. In addition, fluoro-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET)/CT has confirmed high activity in the already known laryngeal and nodal lesions, and has revealed otherwise unknown skeletal metastases. We also reviewed the published clinical features, histopathology, and imaging findings of nine patients with laryngeal EWS confirmed by pathology. The main clinical manifestations of laryngeal EWS are rapidly growing lumps, hoarseness, acute respiratory distress, and aphonia. The EWS tumor cells usually express CD99, vimentin, synaptophysin (Syn), and neuron-specific enolase (NSE) but do not express common antigen (LCA), CD20, and chromaffin granin (CgA). Laryngeal EWS’ CT imaging characteristics are mainly homogeneous, well-bounded soft-tissue masses. Our case suggests that EWS should be considered a differential diagnosis of laryngeal cancer, especially when PET/CT reveals distant bone metastasis, which is more likely to indicate EWS. |
| first_indexed | 2024-03-13T01:27:08Z |
| format | Article |
| id | doaj.art-673bfee75ec34374914f893945680a4d |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T01:27:08Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-673bfee75ec34374914f893945680a4d2023-07-04T13:34:42ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-07-011010.3389/fmed.2023.11673501167350Fluoro-18-fluorodeoxyglucose positron emission tomography/computed tomography detects Ewing’s sarcoma of the larynx with multiple distant bone metastases: a case report and literature reviewXianwen Hu0Yan Liao1Rui Wang2Rui Wen3Dandan Li4Pan Wang5Jiong Cai6Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Obstetrics, Zunyi Hospital of Traditional Chinese Medicine, Zunyi, ChinaDepartment of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaEwing sarcomas (EWS) are highly malignant neoplasms of mesenchymal origin that are rare in the head and neck. Only a few laryngeal EWS have been reported in the literature. We report a 47 years-old man who visited our hospital for medical help after 5 months of hoarseness and sore throat. Computed tomography (CT) showed uneven thickening of the epiglottis fold, right vocal cord, and anterior union. In addition, fluoro-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET)/CT has confirmed high activity in the already known laryngeal and nodal lesions, and has revealed otherwise unknown skeletal metastases. We also reviewed the published clinical features, histopathology, and imaging findings of nine patients with laryngeal EWS confirmed by pathology. The main clinical manifestations of laryngeal EWS are rapidly growing lumps, hoarseness, acute respiratory distress, and aphonia. The EWS tumor cells usually express CD99, vimentin, synaptophysin (Syn), and neuron-specific enolase (NSE) but do not express common antigen (LCA), CD20, and chromaffin granin (CgA). Laryngeal EWS’ CT imaging characteristics are mainly homogeneous, well-bounded soft-tissue masses. Our case suggests that EWS should be considered a differential diagnosis of laryngeal cancer, especially when PET/CT reveals distant bone metastasis, which is more likely to indicate EWS.https://www.frontiersin.org/articles/10.3389/fmed.2023.1167350/fullEwing sarcomalarynxcomputed tomographypositron emission tomographycase report |
| spellingShingle | Xianwen Hu Yan Liao Rui Wang Rui Wen Dandan Li Pan Wang Jiong Cai Fluoro-18-fluorodeoxyglucose positron emission tomography/computed tomography detects Ewing’s sarcoma of the larynx with multiple distant bone metastases: a case report and literature review Frontiers in Medicine Ewing sarcoma larynx computed tomography positron emission tomography case report |
| title | Fluoro-18-fluorodeoxyglucose positron emission tomography/computed tomography detects Ewing’s sarcoma of the larynx with multiple distant bone metastases: a case report and literature review |
| title_full | Fluoro-18-fluorodeoxyglucose positron emission tomography/computed tomography detects Ewing’s sarcoma of the larynx with multiple distant bone metastases: a case report and literature review |
| title_fullStr | Fluoro-18-fluorodeoxyglucose positron emission tomography/computed tomography detects Ewing’s sarcoma of the larynx with multiple distant bone metastases: a case report and literature review |
| title_full_unstemmed | Fluoro-18-fluorodeoxyglucose positron emission tomography/computed tomography detects Ewing’s sarcoma of the larynx with multiple distant bone metastases: a case report and literature review |
| title_short | Fluoro-18-fluorodeoxyglucose positron emission tomography/computed tomography detects Ewing’s sarcoma of the larynx with multiple distant bone metastases: a case report and literature review |
| title_sort | fluoro 18 fluorodeoxyglucose positron emission tomography computed tomography detects ewing s sarcoma of the larynx with multiple distant bone metastases a case report and literature review |
| topic | Ewing sarcoma larynx computed tomography positron emission tomography case report |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1167350/full |
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