Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant?
<i>Clamydophila psittaci</i> (<i>C. psittaci</i>) has been proposed to be an etiologic factor in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the ocular adnexa. However, the pathogenetical significance of the infection has not been...
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MDPI AG
2021-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/11/2069 |
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| author | Uiju Cho Inju Cho Sung Hak Lee Suk Woo Yang Seok Goo Cho Youn Soo Lee Hye Won Lee Gyeongsin Park |
| author_facet | Uiju Cho Inju Cho Sung Hak Lee Suk Woo Yang Seok Goo Cho Youn Soo Lee Hye Won Lee Gyeongsin Park |
| author_sort | Uiju Cho |
| collection | DOAJ |
| description | <i>Clamydophila psittaci</i> (<i>C. psittaci</i>) has been proposed to be an etiologic factor in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the ocular adnexa. However, the pathogenetical significance of the infection has not been fully elucidated. Many previous studies have shown controversial results regarding <i>C.</i> <i>psittaci</i> detection rates in said patients, ranging from 0 to 87%. We investigated the presence of <i>C. psittaci</i> in a single institutional cohort (<i>n</i> = 150) of ocular adnexal MALT lymphoma (OAML) patients in Korea. We tried to exclude the methodological biases derived from the different primer sets in polymerase chain reaction-based studies. For that reason, we applied five sets of primers, including four previously reported and one newly designed primer set. There was no case of <i>C. psittaci</i>-positive OAML in repeated trials validated with appropriate positive and negative controls. All 150 cases showed negative results with five primer sets. These results suggest that the pathogenetic role of <i>C. psittaci</i> in ocular adnexal MALT lymphoma might have been overestimated to date, at least in the Korean population. Therefore, the molecular diagnosis of <i>C. psittaci</i> is considered a very low priority. |
| first_indexed | 2024-03-10T05:34:26Z |
| format | Article |
| id | doaj.art-673ce986f41e4d04ab9a5e5ddf3fcde6 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T05:34:26Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-673ce986f41e4d04ab9a5e5ddf3fcde62023-11-22T23:01:53ZengMDPI AGDiagnostics2075-44182021-11-011111206910.3390/diagnostics11112069Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant?Uiju Cho0Inju Cho1Sung Hak Lee2Suk Woo Yang3Seok Goo Cho4Youn Soo Lee5Hye Won Lee6Gyeongsin Park7Department of Pathology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Pathology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Pathology, St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Opthalmology, St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Internal Medicine, St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Pathology, St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Pathology, School of Medicine, Keimyung University, Daegu 42601, KoreaDepartment of Pathology, St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea<i>Clamydophila psittaci</i> (<i>C. psittaci</i>) has been proposed to be an etiologic factor in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the ocular adnexa. However, the pathogenetical significance of the infection has not been fully elucidated. Many previous studies have shown controversial results regarding <i>C.</i> <i>psittaci</i> detection rates in said patients, ranging from 0 to 87%. We investigated the presence of <i>C. psittaci</i> in a single institutional cohort (<i>n</i> = 150) of ocular adnexal MALT lymphoma (OAML) patients in Korea. We tried to exclude the methodological biases derived from the different primer sets in polymerase chain reaction-based studies. For that reason, we applied five sets of primers, including four previously reported and one newly designed primer set. There was no case of <i>C. psittaci</i>-positive OAML in repeated trials validated with appropriate positive and negative controls. All 150 cases showed negative results with five primer sets. These results suggest that the pathogenetic role of <i>C. psittaci</i> in ocular adnexal MALT lymphoma might have been overestimated to date, at least in the Korean population. Therefore, the molecular diagnosis of <i>C. psittaci</i> is considered a very low priority.https://www.mdpi.com/2075-4418/11/11/2069<i>Chlamydophila</i> <i>psittaci</i><i>Chlamydia</i>lymphomaB cellmarginal zoneMALT lymphoma |
| spellingShingle | Uiju Cho Inju Cho Sung Hak Lee Suk Woo Yang Seok Goo Cho Youn Soo Lee Hye Won Lee Gyeongsin Park Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant? Diagnostics <i>Chlamydophila</i> <i>psittaci</i> <i>Chlamydia</i> lymphoma B cell marginal zone MALT lymphoma |
| title | Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant? |
| title_full | Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant? |
| title_fullStr | Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant? |
| title_full_unstemmed | Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant? |
| title_short | Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant? |
| title_sort | lack of association between i chlamydophila psittaci i and ocular adnexal malt lymphoma in korean patients is the geographic or genetic difference significant |
| topic | <i>Chlamydophila</i> <i>psittaci</i> <i>Chlamydia</i> lymphoma B cell marginal zone MALT lymphoma |
| url | https://www.mdpi.com/2075-4418/11/11/2069 |
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