The Susceptibility and Potential Functions of the LBX1 Gene in Adolescent Idiopathic Scoliosis
Genome-wide association studies have identified many susceptibility genes for adolescent idiopathic scoliosis (AIS). However, most of the results are hard to be replicated in multi-ethnic populations. LBX1 is the most promising candidate gene in the etiology of AIS. We aimed to appraise the literatu...
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2020.614984/full |
| _version_ | 1818964212371685376 |
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| author | Ming Luo Yuxiao Zhang Shishu Huang Yueming Song |
| author_facet | Ming Luo Yuxiao Zhang Shishu Huang Yueming Song |
| author_sort | Ming Luo |
| collection | DOAJ |
| description | Genome-wide association studies have identified many susceptibility genes for adolescent idiopathic scoliosis (AIS). However, most of the results are hard to be replicated in multi-ethnic populations. LBX1 is the most promising candidate gene in the etiology of AIS. We aimed to appraise the literature for the association of LBX1 gene polymorphisms with susceptibility and curve progression in AIS. We also reviewed the function of the LBX1 gene in muscle progenitor cell migration and neuronal determination processes. Three susceptibility loci (rs11190870, rs625039, and rs11598564) near the LBX1 gene, as well as another susceptibility locus (rs678741), related to LBX1 regulation, have been successfully verified to have robust associations with AIS in multi-ethnic populations. The LBX1 gene plays an essential role in regulating the migration and proliferation of muscle precursor cells, and it is known to play a role in neuronal determination processes, especially for the fate of somatosensory relay neurons. The LBX1 gene is the most promising candidate gene in AIS susceptibility due to its position and possible functions in muscle progenitor cell migration and neuronal determination processes. The causality between susceptibility loci related to the LBX1 gene and the pathogenesis of AIS deserves to be explored with further integrated genome-wide and epigenome-wide association studies. |
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| id | doaj.art-673e9cef35af49e6865f99d7947865a0 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-20T12:57:31Z |
| publishDate | 2021-01-01 |
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| series | Frontiers in Genetics |
| spelling | doaj.art-673e9cef35af49e6865f99d7947865a02022-12-21T19:40:02ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-01-011110.3389/fgene.2020.614984614984The Susceptibility and Potential Functions of the LBX1 Gene in Adolescent Idiopathic ScoliosisMing Luo0Yuxiao Zhang1Shishu Huang2Yueming Song3Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaWest China Hospital and West China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaGenome-wide association studies have identified many susceptibility genes for adolescent idiopathic scoliosis (AIS). However, most of the results are hard to be replicated in multi-ethnic populations. LBX1 is the most promising candidate gene in the etiology of AIS. We aimed to appraise the literature for the association of LBX1 gene polymorphisms with susceptibility and curve progression in AIS. We also reviewed the function of the LBX1 gene in muscle progenitor cell migration and neuronal determination processes. Three susceptibility loci (rs11190870, rs625039, and rs11598564) near the LBX1 gene, as well as another susceptibility locus (rs678741), related to LBX1 regulation, have been successfully verified to have robust associations with AIS in multi-ethnic populations. The LBX1 gene plays an essential role in regulating the migration and proliferation of muscle precursor cells, and it is known to play a role in neuronal determination processes, especially for the fate of somatosensory relay neurons. The LBX1 gene is the most promising candidate gene in AIS susceptibility due to its position and possible functions in muscle progenitor cell migration and neuronal determination processes. The causality between susceptibility loci related to the LBX1 gene and the pathogenesis of AIS deserves to be explored with further integrated genome-wide and epigenome-wide association studies.https://www.frontiersin.org/articles/10.3389/fgene.2020.614984/fulladolescent idiopathic scoliosisLBX1genome-wide association studysusceptibilitycurve progressionetiology |
| spellingShingle | Ming Luo Yuxiao Zhang Shishu Huang Yueming Song The Susceptibility and Potential Functions of the LBX1 Gene in Adolescent Idiopathic Scoliosis Frontiers in Genetics adolescent idiopathic scoliosis LBX1 genome-wide association study susceptibility curve progression etiology |
| title | The Susceptibility and Potential Functions of the LBX1 Gene in Adolescent Idiopathic Scoliosis |
| title_full | The Susceptibility and Potential Functions of the LBX1 Gene in Adolescent Idiopathic Scoliosis |
| title_fullStr | The Susceptibility and Potential Functions of the LBX1 Gene in Adolescent Idiopathic Scoliosis |
| title_full_unstemmed | The Susceptibility and Potential Functions of the LBX1 Gene in Adolescent Idiopathic Scoliosis |
| title_short | The Susceptibility and Potential Functions of the LBX1 Gene in Adolescent Idiopathic Scoliosis |
| title_sort | susceptibility and potential functions of the lbx1 gene in adolescent idiopathic scoliosis |
| topic | adolescent idiopathic scoliosis LBX1 genome-wide association study susceptibility curve progression etiology |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2020.614984/full |
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