Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats

Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats

Abstract Background Major depressive disorder (MDD) is a recurring affective disorder that is two times more prevalent in females than males. Evidence supports immune system dysfunction as a major contributing factor to MDD, notably in a sexually dimorphic manner. Nuclear factor erythroid 2-related...

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Bibliographic Details
Main Authors: Ryan T. McCallum, Rachel-Karson Thériault, Joshua D. Manduca, Isaac S. B. Russell, Angel M. Culmer, Janan Shoja Doost, Tami A. Martino, Melissa L. Perreault
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Biology of Sex Differences
Subjects:
Sex differences
Major depressive disorder
Neuroinflammation
Nuclear factor erythroid 2-related factor 2
Dimethyl fumarate
Online Access:https://doi.org/10.1186/s13293-024-00589-0

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