ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens

ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens

IntroductionEstrogens inhibit bone resorption and preserve bone mass, at least in part, via direct effects on osteoclasts. The binding of RANKL, the critical cytokine for osteoclast differentiation, to its receptor in osteoclast precursor cells of the monocyte lineage recruits the adaptor protein TR...

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Bibliographic Details
Main Authors: Adriana Marques-Carvalho, Vilma A. Sardão, Ha-Neui Kim, Maria Almeida
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Endocrinology
Subjects:
osteoclasts
bone resorption
estrogens
ECSIT
mitochondrial metabolism
complex I
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1110369/full

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