Endocrine Crosstalk Between Skeletal Muscle and the Brain
Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal muscle-initiated crosstalk with other tissues is accomplished though the secretion of myokines, protein hormones wh...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00698/full |
| _version_ | 1818154772340932608 |
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| author | Julien Delezie Christoph Handschin |
| author_facet | Julien Delezie Christoph Handschin |
| author_sort | Julien Delezie |
| collection | DOAJ |
| description | Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal muscle-initiated crosstalk with other tissues is accomplished though the secretion of myokines, protein hormones which can exert autocrine, paracrine and long-distance endocrine effects. In addition, the enhanced release or uptake of metabolites from and into contracting muscle cells, respectively, likewise can act as a powerful mediator of tissue interactions, in particular in regard to the central nervous system. The present review will discuss the current stage of knowledge regarding how exercise and the muscle secretome improve a broad range of brain functions related to vascularization, neuroplasticity, memory, sleep and mood. Even though the molecular and cellular mechanisms underlying the communication between muscle and brain is still poorly understood, physical activity represents one of the most effective strategies to reduce the prevalence and incidence of depression, cognitive, metabolic or degenerative neuronal disorders, and thus warrants further study. |
| first_indexed | 2024-12-11T14:31:49Z |
| format | Article |
| id | doaj.art-6743247b3bc54cbeba56775c7641a402 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T14:31:49Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-6743247b3bc54cbeba56775c7641a4022022-12-22T01:02:24ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-08-01910.3389/fneur.2018.00698356938Endocrine Crosstalk Between Skeletal Muscle and the BrainJulien DelezieChristoph HandschinSkeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal muscle-initiated crosstalk with other tissues is accomplished though the secretion of myokines, protein hormones which can exert autocrine, paracrine and long-distance endocrine effects. In addition, the enhanced release or uptake of metabolites from and into contracting muscle cells, respectively, likewise can act as a powerful mediator of tissue interactions, in particular in regard to the central nervous system. The present review will discuss the current stage of knowledge regarding how exercise and the muscle secretome improve a broad range of brain functions related to vascularization, neuroplasticity, memory, sleep and mood. Even though the molecular and cellular mechanisms underlying the communication between muscle and brain is still poorly understood, physical activity represents one of the most effective strategies to reduce the prevalence and incidence of depression, cognitive, metabolic or degenerative neuronal disorders, and thus warrants further study.https://www.frontiersin.org/article/10.3389/fneur.2018.00698/fullphysical exercisemyokinesmetabolitesBDNFPGC-1αhippocampus |
| spellingShingle | Julien Delezie Christoph Handschin Endocrine Crosstalk Between Skeletal Muscle and the Brain Frontiers in Neurology physical exercise myokines metabolites BDNF PGC-1α hippocampus |
| title | Endocrine Crosstalk Between Skeletal Muscle and the Brain |
| title_full | Endocrine Crosstalk Between Skeletal Muscle and the Brain |
| title_fullStr | Endocrine Crosstalk Between Skeletal Muscle and the Brain |
| title_full_unstemmed | Endocrine Crosstalk Between Skeletal Muscle and the Brain |
| title_short | Endocrine Crosstalk Between Skeletal Muscle and the Brain |
| title_sort | endocrine crosstalk between skeletal muscle and the brain |
| topic | physical exercise myokines metabolites BDNF PGC-1α hippocampus |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00698/full |
| work_keys_str_mv | AT juliendelezie endocrinecrosstalkbetweenskeletalmuscleandthebrain AT christophhandschin endocrinecrosstalkbetweenskeletalmuscleandthebrain |