Association between HPV infection and prostate cancer in a Mexican population
Abstract The aim of this study was to evaluate the association between prostate cancer (PCa) and Human papillomavirus (HPV) infection in the Mexican population. We studied 356 paraffin-embedded tissues from unrelated Mexican men with PCa or benign prostatic hyperplasia (BPH), with the latter serving...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2018-11-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000500781&lng=en&tlng=en |
| _version_ | 1811339677004726272 |
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| author | Olivia Medel-Flores Vania Alejandra Valenzuela-Rodríguez Rodolfo Ocadiz-Delgado Leonardo Josué Castro-Muñoz Sandra Hernández-Leyva Gabriel Lara-Hernández Jesús-Gabriel Silva-Escobedo Patricio Gariglio Vidal Virginia Sánchez-Monroy |
| author_facet | Olivia Medel-Flores Vania Alejandra Valenzuela-Rodríguez Rodolfo Ocadiz-Delgado Leonardo Josué Castro-Muñoz Sandra Hernández-Leyva Gabriel Lara-Hernández Jesús-Gabriel Silva-Escobedo Patricio Gariglio Vidal Virginia Sánchez-Monroy |
| author_sort | Olivia Medel-Flores |
| collection | DOAJ |
| description | Abstract The aim of this study was to evaluate the association between prostate cancer (PCa) and Human papillomavirus (HPV) infection in the Mexican population. We studied 356 paraffin-embedded tissues from unrelated Mexican men with PCa or benign prostatic hyperplasia (BPH), with the latter serving as control. HPV detection was performed by polymerase chain reaction (PCR) using universal primers, and viral genotypes were detected using sequencing or multiplex PCR. Light microscopy analyses enabled the identification of koilocytes in samples subsequently analyzed for HPV detection by in situ PCR and for p16-INK4A expression by immunohistochemistry. The results showed that high risk- (HR) HPVs were detected in 37/189 (19.6%) PCa specimens compared to 16/167 (9.6%) of BHP specimens (odds ratio 2.3; 95% CI= 1.2 to 4.3; p=0.01). These data suggest HR-HPV may play a role in PCa. HPV 52 and 58 were the most frequent genotypes (33 and 17%, respectively) detected in the population studied. Koilocytes were detected in all in situ PCR-HPV-positive samples, representing a pathognomonic feature of infection, and we observed the overexpression of p16-INK4A in HPV-positive samples compared to HPV-negative samples, indirectly suggesting the presence of HR-HPV E7 oncoprotein. These results suggest that HPV infection plays an important role in prostate cancer development. |
| first_indexed | 2024-04-13T18:30:20Z |
| format | Article |
| id | doaj.art-6743731deaab49b7a46dcefeac95c223 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-04-13T18:30:20Z |
| publishDate | 2018-11-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-6743731deaab49b7a46dcefeac95c2232022-12-22T02:35:05ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852018-11-0141478178910.1590/1678-4685-gmb-2017-0331S1415-47572018000500781Association between HPV infection and prostate cancer in a Mexican populationOlivia Medel-FloresVania Alejandra Valenzuela-RodríguezRodolfo Ocadiz-DelgadoLeonardo Josué Castro-MuñozSandra Hernández-LeyvaGabriel Lara-HernándezJesús-Gabriel Silva-EscobedoPatricio Gariglio VidalVirginia Sánchez-MonroyAbstract The aim of this study was to evaluate the association between prostate cancer (PCa) and Human papillomavirus (HPV) infection in the Mexican population. We studied 356 paraffin-embedded tissues from unrelated Mexican men with PCa or benign prostatic hyperplasia (BPH), with the latter serving as control. HPV detection was performed by polymerase chain reaction (PCR) using universal primers, and viral genotypes were detected using sequencing or multiplex PCR. Light microscopy analyses enabled the identification of koilocytes in samples subsequently analyzed for HPV detection by in situ PCR and for p16-INK4A expression by immunohistochemistry. The results showed that high risk- (HR) HPVs were detected in 37/189 (19.6%) PCa specimens compared to 16/167 (9.6%) of BHP specimens (odds ratio 2.3; 95% CI= 1.2 to 4.3; p=0.01). These data suggest HR-HPV may play a role in PCa. HPV 52 and 58 were the most frequent genotypes (33 and 17%, respectively) detected in the population studied. Koilocytes were detected in all in situ PCR-HPV-positive samples, representing a pathognomonic feature of infection, and we observed the overexpression of p16-INK4A in HPV-positive samples compared to HPV-negative samples, indirectly suggesting the presence of HR-HPV E7 oncoprotein. These results suggest that HPV infection plays an important role in prostate cancer development.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000500781&lng=en&tlng=enHPVprostatecancerkoilocytes |
| spellingShingle | Olivia Medel-Flores Vania Alejandra Valenzuela-Rodríguez Rodolfo Ocadiz-Delgado Leonardo Josué Castro-Muñoz Sandra Hernández-Leyva Gabriel Lara-Hernández Jesús-Gabriel Silva-Escobedo Patricio Gariglio Vidal Virginia Sánchez-Monroy Association between HPV infection and prostate cancer in a Mexican population Genetics and Molecular Biology HPV prostate cancer koilocytes |
| title | Association between HPV infection and prostate cancer in a Mexican population |
| title_full | Association between HPV infection and prostate cancer in a Mexican population |
| title_fullStr | Association between HPV infection and prostate cancer in a Mexican population |
| title_full_unstemmed | Association between HPV infection and prostate cancer in a Mexican population |
| title_short | Association between HPV infection and prostate cancer in a Mexican population |
| title_sort | association between hpv infection and prostate cancer in a mexican population |
| topic | HPV prostate cancer koilocytes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000500781&lng=en&tlng=en |
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