Correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver: a multi-center retrospective cohort study
Background/Aims The controlled attenuation parameter (CAP), based on transient elastography, is widely used for noninvasive assessment of the degree of hepatic steatosis (HS). We investigated the correlation of the degree HS between CAP and ultrasound (US) in patients with HS. Methods In total, 986...
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| Format: | Article |
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The Korean Association of Internal Medicine
2020-11-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://www.kjim.org/upload/pdf/kjim-2018-309.pdf |
| _version_ | 1818891355616706560 |
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| author | Jeong-Ju Yoo Yang Jae Yoo Woo Ram Moon Seung Up Kim Soung Won Jeong Ha Na Park Min Gyu Park Jae Young Jang Su Yeon Park Beom Kyung Kim Jun Yong Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Sang Gyune Kim Young Seok Kim Ji Hoon Kim Jong Eun Yeon Kwan Soo Byun |
| author_facet | Jeong-Ju Yoo Yang Jae Yoo Woo Ram Moon Seung Up Kim Soung Won Jeong Ha Na Park Min Gyu Park Jae Young Jang Su Yeon Park Beom Kyung Kim Jun Yong Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Sang Gyune Kim Young Seok Kim Ji Hoon Kim Jong Eun Yeon Kwan Soo Byun |
| author_sort | Jeong-Ju Yoo |
| collection | DOAJ |
| description | Background/Aims The controlled attenuation parameter (CAP), based on transient elastography, is widely used for noninvasive assessment of the degree of hepatic steatosis (HS). We investigated the correlation of the degree HS between CAP and ultrasound (US) in patients with HS. Methods In total, 986 patients with US-based HS who underwent transient elastography within 1 month were evaluated. The US-based grade of HS was categorized as mild (grade 1), moderate (grade 2), or severe (grade 3). Results The CAP was significantly correlated with the US-based grade of HS (r = 0.458, p < 0.001). The median CAP value of each US-based HS grade showed a positive correlation with grade (271.1, 303.7, and 326.7 dB/m for grades 1, 2, and 3). In a multivariate analysis, the US-based HS grade, body mass index, serum albumin, alanine aminotransferase, and total cholesterol, and liver stiffness were all significantly correlated with the CAP value (all p < 0.05). The areas under the receiver operating characteristic curves for grade 2 to 3 and grade 3 HS were 0.749 (95% confidence interval [CI], 0.714 to 0.784) and 0.738 (95% CI, 0.704 to 0.772). The optimal cut-off CAP values to maximize the sum of the sensitivity and specificity for grade 2 to 3 and grade 3 HS were 284.5 dB/m (sensitivity 78.6%, specificity 61.7%) and 298.5 dB/m (sensitivity 84.6%, specificity 55.6%). Conclusions The correlation of the degree of HS between CAP and US was significantly high in patients with HS, and the optimal cut-off CAP values for grade 2 to 3 and grade 3 HS were 284.5 and 298.5 dB/m. |
| first_indexed | 2024-12-19T17:39:30Z |
| format | Article |
| id | doaj.art-67444eae79d641f39a6e649f8cbfb186 |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-19T17:39:30Z |
| publishDate | 2020-11-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-67444eae79d641f39a6e649f8cbfb1862022-12-21T20:12:15ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482020-11-013561346135310.3904/kjim.2018.309170257Correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver: a multi-center retrospective cohort studyJeong-Ju Yoo0Yang Jae Yoo1Woo Ram Moon2Seung Up Kim3Soung Won Jeong4Ha Na Park5Min Gyu Park6Jae Young Jang7Su Yeon Park8Beom Kyung Kim9Jun Yong Park10Do Young Kim11Sang Hoon Ahn12Kwang-Hyub Han13Sang Gyune Kim14Young Seok Kim15Ji Hoon Kim16Jong Eun Yeon17Kwan Soo Byun18 Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea Department of Biostatistics, Soonchunhyang University Seoul Hospital, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaBackground/Aims The controlled attenuation parameter (CAP), based on transient elastography, is widely used for noninvasive assessment of the degree of hepatic steatosis (HS). We investigated the correlation of the degree HS between CAP and ultrasound (US) in patients with HS. Methods In total, 986 patients with US-based HS who underwent transient elastography within 1 month were evaluated. The US-based grade of HS was categorized as mild (grade 1), moderate (grade 2), or severe (grade 3). Results The CAP was significantly correlated with the US-based grade of HS (r = 0.458, p < 0.001). The median CAP value of each US-based HS grade showed a positive correlation with grade (271.1, 303.7, and 326.7 dB/m for grades 1, 2, and 3). In a multivariate analysis, the US-based HS grade, body mass index, serum albumin, alanine aminotransferase, and total cholesterol, and liver stiffness were all significantly correlated with the CAP value (all p < 0.05). The areas under the receiver operating characteristic curves for grade 2 to 3 and grade 3 HS were 0.749 (95% confidence interval [CI], 0.714 to 0.784) and 0.738 (95% CI, 0.704 to 0.772). The optimal cut-off CAP values to maximize the sum of the sensitivity and specificity for grade 2 to 3 and grade 3 HS were 284.5 dB/m (sensitivity 78.6%, specificity 61.7%) and 298.5 dB/m (sensitivity 84.6%, specificity 55.6%). Conclusions The correlation of the degree of HS between CAP and US was significantly high in patients with HS, and the optimal cut-off CAP values for grade 2 to 3 and grade 3 HS were 284.5 and 298.5 dB/m.http://www.kjim.org/upload/pdf/kjim-2018-309.pdffatty liverelasticity imaging techniquesultrasonography |
| spellingShingle | Jeong-Ju Yoo Yang Jae Yoo Woo Ram Moon Seung Up Kim Soung Won Jeong Ha Na Park Min Gyu Park Jae Young Jang Su Yeon Park Beom Kyung Kim Jun Yong Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Sang Gyune Kim Young Seok Kim Ji Hoon Kim Jong Eun Yeon Kwan Soo Byun Correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver: a multi-center retrospective cohort study The Korean Journal of Internal Medicine fatty liver elasticity imaging techniques ultrasonography |
| title | Correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver: a multi-center retrospective cohort study |
| title_full | Correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver: a multi-center retrospective cohort study |
| title_fullStr | Correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver: a multi-center retrospective cohort study |
| title_full_unstemmed | Correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver: a multi-center retrospective cohort study |
| title_short | Correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver: a multi-center retrospective cohort study |
| title_sort | correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver a multi center retrospective cohort study |
| topic | fatty liver elasticity imaging techniques ultrasonography |
| url | http://www.kjim.org/upload/pdf/kjim-2018-309.pdf |
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