Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative Materials
Polymeric materials are the first choice for restoring tooth cavities, bonding tooth-colored fillings, sealing root canal systems, and many other dental restorative applications. However, polymeric materials are highly susceptible to bacterial attachment and colonization, leading to dental diseases....
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/7/3/83 |
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| author | Heba Mitwalli Rashed Alsahafi Abdulrahman A. Balhaddad Michael D. Weir Hockin H. K. Xu Mary Anne S. Melo |
| author_facet | Heba Mitwalli Rashed Alsahafi Abdulrahman A. Balhaddad Michael D. Weir Hockin H. K. Xu Mary Anne S. Melo |
| author_sort | Heba Mitwalli |
| collection | DOAJ |
| description | Polymeric materials are the first choice for restoring tooth cavities, bonding tooth-colored fillings, sealing root canal systems, and many other dental restorative applications. However, polymeric materials are highly susceptible to bacterial attachment and colonization, leading to dental diseases. Many approaches have been investigated to minimize the formation of biofilms over polymeric restorative materials and at the tooth/material interfaces. Among them, contact-killing compounds have shown promising results to inhibit dental biofilms. Contact-killing compounds can be immobilized within the polymer structure, delivering a long-lasting effect with no leaching or release, thus providing advantages compared to release-based materials. This review discusses cutting-edge research on the development of contact-killing compounds in dental restorative materials to target oral pathogens. Contact-killing compounds in resin composite restorations, dental adhesives, root canal sealers, denture-based materials, and crown cements have all demonstrated promising antibacterial properties. Contact-killing restorative materials have been found to effectively inhibit the growth and activities of several oral pathogens related to dental caries, periodontal diseases, endodontic, and fungal infections. Further laboratory optimization and clinical trials using translational models are needed to confirm the clinical applicability of this new generation of contact-killing dental restorative materials. |
| first_indexed | 2024-03-10T18:05:10Z |
| format | Article |
| id | doaj.art-67447b20874e49e797421c98be96bad7 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T18:05:10Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-67447b20874e49e797421c98be96bad72023-11-20T08:32:17ZengMDPI AGBioengineering2306-53542020-07-01738310.3390/bioengineering7030083Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative MaterialsHeba Mitwalli0Rashed Alsahafi1Abdulrahman A. Balhaddad2Michael D. Weir3Hockin H. K. Xu4Mary Anne S. Melo5Program in Biomedical Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USAProgram in Biomedical Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USAProgram in Biomedical Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USAProgram in Biomedical Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USAProgram in Biomedical Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USAProgram in Biomedical Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USAPolymeric materials are the first choice for restoring tooth cavities, bonding tooth-colored fillings, sealing root canal systems, and many other dental restorative applications. However, polymeric materials are highly susceptible to bacterial attachment and colonization, leading to dental diseases. Many approaches have been investigated to minimize the formation of biofilms over polymeric restorative materials and at the tooth/material interfaces. Among them, contact-killing compounds have shown promising results to inhibit dental biofilms. Contact-killing compounds can be immobilized within the polymer structure, delivering a long-lasting effect with no leaching or release, thus providing advantages compared to release-based materials. This review discusses cutting-edge research on the development of contact-killing compounds in dental restorative materials to target oral pathogens. Contact-killing compounds in resin composite restorations, dental adhesives, root canal sealers, denture-based materials, and crown cements have all demonstrated promising antibacterial properties. Contact-killing restorative materials have been found to effectively inhibit the growth and activities of several oral pathogens related to dental caries, periodontal diseases, endodontic, and fungal infections. Further laboratory optimization and clinical trials using translational models are needed to confirm the clinical applicability of this new generation of contact-killing dental restorative materials.https://www.mdpi.com/2306-5354/7/3/83antibacterial agentspolymersdental cariesbiofilmscomposite resins |
| spellingShingle | Heba Mitwalli Rashed Alsahafi Abdulrahman A. Balhaddad Michael D. Weir Hockin H. K. Xu Mary Anne S. Melo Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative Materials Bioengineering antibacterial agents polymers dental caries biofilms composite resins |
| title | Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative Materials |
| title_full | Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative Materials |
| title_fullStr | Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative Materials |
| title_full_unstemmed | Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative Materials |
| title_short | Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative Materials |
| title_sort | emerging contact killing antibacterial strategies for developing anti biofilm dental polymeric restorative materials |
| topic | antibacterial agents polymers dental caries biofilms composite resins |
| url | https://www.mdpi.com/2306-5354/7/3/83 |
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