Aging conundrum: A perspective for ovarian aging
Progressive loss of physiological integrity and accumulation of degenerative changes leading to functional impairment and increased susceptibility to diseases are the main features of aging. The ovary, the key organ that maintains female reproductive and endocrine function, enters aging earlier and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.952471/full |
| _version_ | 1818483921693704192 |
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| author | Jiachen Wu Yang Liu Yinhua Song Lingjuan Wang Jihui Ai Kezhen Li |
| author_facet | Jiachen Wu Yang Liu Yinhua Song Lingjuan Wang Jihui Ai Kezhen Li |
| author_sort | Jiachen Wu |
| collection | DOAJ |
| description | Progressive loss of physiological integrity and accumulation of degenerative changes leading to functional impairment and increased susceptibility to diseases are the main features of aging. The ovary, the key organ that maintains female reproductive and endocrine function, enters aging earlier and faster than other organs and has attracted extensive attention from society. Ovarian aging is mainly characterized by the progressive decline in the number and quality of oocytes, the regulatory mechanisms of which have yet to be systematically elucidated. This review discusses the hallmarks of aging to further highlight the main characteristics of ovarian aging and attempt to explore its clinical symptoms and underlying mechanisms. Finally, the intervention strategies related to aging are elaborated, especially the potential role of stem cells and cryopreservation of embryos, oocytes, or ovarian tissue in the delay of ovarian aging. |
| first_indexed | 2024-12-10T15:48:23Z |
| format | Article |
| id | doaj.art-6745e33a5a024eb4941bc65c3ec95d94 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T15:48:23Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-6745e33a5a024eb4941bc65c3ec95d942022-12-22T01:42:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-08-011310.3389/fendo.2022.952471952471Aging conundrum: A perspective for ovarian agingJiachen WuYang LiuYinhua SongLingjuan WangJihui AiKezhen LiProgressive loss of physiological integrity and accumulation of degenerative changes leading to functional impairment and increased susceptibility to diseases are the main features of aging. The ovary, the key organ that maintains female reproductive and endocrine function, enters aging earlier and faster than other organs and has attracted extensive attention from society. Ovarian aging is mainly characterized by the progressive decline in the number and quality of oocytes, the regulatory mechanisms of which have yet to be systematically elucidated. This review discusses the hallmarks of aging to further highlight the main characteristics of ovarian aging and attempt to explore its clinical symptoms and underlying mechanisms. Finally, the intervention strategies related to aging are elaborated, especially the potential role of stem cells and cryopreservation of embryos, oocytes, or ovarian tissue in the delay of ovarian aging.https://www.frontiersin.org/articles/10.3389/fendo.2022.952471/fulloocyteovaryagingovarian aginginterventions |
| spellingShingle | Jiachen Wu Yang Liu Yinhua Song Lingjuan Wang Jihui Ai Kezhen Li Aging conundrum: A perspective for ovarian aging Frontiers in Endocrinology oocyte ovary aging ovarian aging interventions |
| title | Aging conundrum: A perspective for ovarian aging |
| title_full | Aging conundrum: A perspective for ovarian aging |
| title_fullStr | Aging conundrum: A perspective for ovarian aging |
| title_full_unstemmed | Aging conundrum: A perspective for ovarian aging |
| title_short | Aging conundrum: A perspective for ovarian aging |
| title_sort | aging conundrum a perspective for ovarian aging |
| topic | oocyte ovary aging ovarian aging interventions |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.952471/full |
| work_keys_str_mv | AT jiachenwu agingconundrumaperspectiveforovarianaging AT yangliu agingconundrumaperspectiveforovarianaging AT yinhuasong agingconundrumaperspectiveforovarianaging AT lingjuanwang agingconundrumaperspectiveforovarianaging AT jihuiai agingconundrumaperspectiveforovarianaging AT kezhenli agingconundrumaperspectiveforovarianaging |