Avoidance memory requires CaMKII activity to persist after recall
Abstract Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-11-01
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| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13041-021-00877-5 |
| _version_ | 1818570204572024832 |
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| author | Andressa Radiske Maria Carolina Gonzalez Janine I. Rossato Gênedy Apolinário João R. de Oliveira Lia R. M. Bevilaqua Martín Cammarota |
| author_facet | Andressa Radiske Maria Carolina Gonzalez Janine I. Rossato Gênedy Apolinário João R. de Oliveira Lia R. M. Bevilaqua Martín Cammarota |
| author_sort | Andressa Radiske |
| collection | DOAJ |
| description | Abstract Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses. |
| first_indexed | 2024-12-14T06:57:36Z |
| format | Article |
| id | doaj.art-674679b96aa943ea8b8f97e59bc6c340 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-12-14T06:57:36Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-674679b96aa943ea8b8f97e59bc6c3402022-12-21T23:12:35ZengBMCMolecular Brain1756-66062021-11-011411410.1186/s13041-021-00877-5Avoidance memory requires CaMKII activity to persist after recallAndressa Radiske0Maria Carolina Gonzalez1Janine I. Rossato2Gênedy Apolinário3João R. de Oliveira4Lia R. M. Bevilaqua5Martín Cammarota6Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do NorteMemory Research Laboratory, Brain Institute, Federal University of Rio Grande do NorteMemory Research Laboratory, Brain Institute, Federal University of Rio Grande do NorteMemory Research Laboratory, Brain Institute, Federal University of Rio Grande do NorteMemory Research Laboratory, Brain Institute, Federal University of Rio Grande do NorteMemory Research Laboratory, Brain Institute, Federal University of Rio Grande do NorteMemory Research Laboratory, Brain Institute, Federal University of Rio Grande do NorteAbstract Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses.https://doi.org/10.1186/s13041-021-00877-5ReconsolidationPTSDFearHippocampusRetrieval |
| spellingShingle | Andressa Radiske Maria Carolina Gonzalez Janine I. Rossato Gênedy Apolinário João R. de Oliveira Lia R. M. Bevilaqua Martín Cammarota Avoidance memory requires CaMKII activity to persist after recall Molecular Brain Reconsolidation PTSD Fear Hippocampus Retrieval |
| title | Avoidance memory requires CaMKII activity to persist after recall |
| title_full | Avoidance memory requires CaMKII activity to persist after recall |
| title_fullStr | Avoidance memory requires CaMKII activity to persist after recall |
| title_full_unstemmed | Avoidance memory requires CaMKII activity to persist after recall |
| title_short | Avoidance memory requires CaMKII activity to persist after recall |
| title_sort | avoidance memory requires camkii activity to persist after recall |
| topic | Reconsolidation PTSD Fear Hippocampus Retrieval |
| url | https://doi.org/10.1186/s13041-021-00877-5 |
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