Binary and ternary inclusion complexation of lapatinib ditosylate with β-cyclodextrin: preparation, evaluation and in vitro anticancer activity

Binary and ternary inclusion complexation of lapatinib ditosylate with β-cyclodextrin: preparation, evaluation and in vitro anticancer activity

Abstract Background Lapatinib ditosylate, an efficient tyrosine kinase inhibitor for breast cancer, poses pharmacokinetic issues, hence developing its oral delivery system is troublesome. The poor aqueous solubility of this medicament is a key impediment in developing its successful formulation. So,...

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Bibliographic Details
Main Authors: Preeti Tanaji Mane, Balaji Sopanrao Wakure, Pravin Shridhar Wakte
Format: Article
Language:English
Published: SpringerOpen 2022-12-01
Series:Beni-Suef University Journal of Basic and Applied Sciences
Subjects:
Lapatinib ditosylate
β-cyclodextrin
Polymer
Organic acid
Complexation
Ternary complex
Online Access:https://doi.org/10.1186/s43088-022-00332-x

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