Association between maternal exposure to environmental endocrine disruptors and the risk of congenital heart diseases in offspring: a systematic review and meta-analysis
Congenital heart disease (CHD) is the most common type of congenital malformation and the leading cause of death in newborns. Some observational studies have investigated the relationship between exposure to environmental endocrine disruptors (EEDs) and CHD in pregnant women. However, the findings o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2024-01-01
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| Series: | Environmental Research Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/1748-9326/ad21b2 |
| _version_ | 1797333806845263872 |
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| author | Kai Pan Jie Xu Chengxing Wang Zhen Mao Yuzhu Xu Haoke Zhang Jie Yu |
| author_facet | Kai Pan Jie Xu Chengxing Wang Zhen Mao Yuzhu Xu Haoke Zhang Jie Yu |
| author_sort | Kai Pan |
| collection | DOAJ |
| description | Congenital heart disease (CHD) is the most common type of congenital malformation and the leading cause of death in newborns. Some observational studies have investigated the relationship between exposure to environmental endocrine disruptors (EEDs) and CHD in pregnant women. However, the findings of epidemiological studies in different countries and regions remain controversial and exhibit significant variations. This meta-analysis aimed to explore the relationship between exposure to EEDs and CHD in pregnant women, hoping to provide some insights into related research in different regions and further demonstrate the relationship between the two. Three databases (PubMed, Embase, and Web of Science) were searched, and 17 studies with 1373 117 participants were selected, including 3 on polycyclic aromatic hydrocarbons (PAHs), 5 on pesticides/insecticides, 4 on phthalates, 4 on alkylphenolic compounds, and 7 on heavy metals. The Newcastle–Ottawa Scale was used to evaluate the quality of the studies. Begg’s and Egger’s tests were used to determine the publication bias of the studies, and the I ^2 statistics to evaluate the statistical heterogeneity among the studies. The adjusted estimates were pooled using the random-effects and fixed-effects models to explore the association between EEDs and CHD and its subtypes. Maternal exposure to PAHs [odds ratio (OR) = 1.34, 95% confidence interval (CI): 1.17–1.53)] (e.g. PAHs and tetralogy of Fallot, septal defects, and conotruncal defects)], pesticides/insecticides (OR = 1.32, 95% CI: 1.20–1.46), alkylphenolic compounds (OR = 1.46, 95% CI: 1.14–1.86), and heavy metals (arsenic, cadmium, mercury, and lead) (OR = 2.09, 95% CI: 1.53–2.86) during pregnancy was positively associated with CHD in offspring. This study found that exposure to EEDs in pregnant women was positively associated with CHD in offspring. These findings are of great significance for researchers to further study the relationship between the two. |
| first_indexed | 2024-03-08T08:10:30Z |
| format | Article |
| id | doaj.art-674779c46aa543cebb29ce5d4af6148a |
| institution | Directory Open Access Journal |
| issn | 1748-9326 |
| language | English |
| last_indexed | 2024-03-08T08:10:30Z |
| publishDate | 2024-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Environmental Research Letters |
| spelling | doaj.art-674779c46aa543cebb29ce5d4af6148a2024-02-02T08:54:50ZengIOP PublishingEnvironmental Research Letters1748-93262024-01-0119202300210.1088/1748-9326/ad21b2Association between maternal exposure to environmental endocrine disruptors and the risk of congenital heart diseases in offspring: a systematic review and meta-analysisKai Pan0Jie Xu1Chengxing Wang2Zhen Mao3Yuzhu Xu4Haoke Zhang5Jie Yu6School of Public Health, Zunyi Medical University , Zunyi, Guizhou 563000, People’s Republic of ChinaSchool of Public Health, Zunyi Medical University , Zunyi, Guizhou 563000, People’s Republic of ChinaSchool of Public Health, Zunyi Medical University , Zunyi, Guizhou 563000, People’s Republic of ChinaSchool of Environment Science and Spatial Informatics, China University of Mining and Technology , Xuzhou 221008, People’s Republic of ChinaSchool of Public Health, Zunyi Medical University , Zunyi, Guizhou 563000, People’s Republic of ChinaSchool of Public Health, Zunyi Medical University , Zunyi, Guizhou 563000, People’s Republic of ChinaSchool of Public Health, Zunyi Medical University , Zunyi, Guizhou 563000, People’s Republic of ChinaCongenital heart disease (CHD) is the most common type of congenital malformation and the leading cause of death in newborns. Some observational studies have investigated the relationship between exposure to environmental endocrine disruptors (EEDs) and CHD in pregnant women. However, the findings of epidemiological studies in different countries and regions remain controversial and exhibit significant variations. This meta-analysis aimed to explore the relationship between exposure to EEDs and CHD in pregnant women, hoping to provide some insights into related research in different regions and further demonstrate the relationship between the two. Three databases (PubMed, Embase, and Web of Science) were searched, and 17 studies with 1373 117 participants were selected, including 3 on polycyclic aromatic hydrocarbons (PAHs), 5 on pesticides/insecticides, 4 on phthalates, 4 on alkylphenolic compounds, and 7 on heavy metals. The Newcastle–Ottawa Scale was used to evaluate the quality of the studies. Begg’s and Egger’s tests were used to determine the publication bias of the studies, and the I ^2 statistics to evaluate the statistical heterogeneity among the studies. The adjusted estimates were pooled using the random-effects and fixed-effects models to explore the association between EEDs and CHD and its subtypes. Maternal exposure to PAHs [odds ratio (OR) = 1.34, 95% confidence interval (CI): 1.17–1.53)] (e.g. PAHs and tetralogy of Fallot, septal defects, and conotruncal defects)], pesticides/insecticides (OR = 1.32, 95% CI: 1.20–1.46), alkylphenolic compounds (OR = 1.46, 95% CI: 1.14–1.86), and heavy metals (arsenic, cadmium, mercury, and lead) (OR = 2.09, 95% CI: 1.53–2.86) during pregnancy was positively associated with CHD in offspring. This study found that exposure to EEDs in pregnant women was positively associated with CHD in offspring. These findings are of great significance for researchers to further study the relationship between the two.https://doi.org/10.1088/1748-9326/ad21b2congenital heart diseasesenvironmental endocrine disruptorsmaternal exposuremeta-analysis |
| spellingShingle | Kai Pan Jie Xu Chengxing Wang Zhen Mao Yuzhu Xu Haoke Zhang Jie Yu Association between maternal exposure to environmental endocrine disruptors and the risk of congenital heart diseases in offspring: a systematic review and meta-analysis Environmental Research Letters congenital heart diseases environmental endocrine disruptors maternal exposure meta-analysis |
| title | Association between maternal exposure to environmental endocrine disruptors and the risk of congenital heart diseases in offspring: a systematic review and meta-analysis |
| title_full | Association between maternal exposure to environmental endocrine disruptors and the risk of congenital heart diseases in offspring: a systematic review and meta-analysis |
| title_fullStr | Association between maternal exposure to environmental endocrine disruptors and the risk of congenital heart diseases in offspring: a systematic review and meta-analysis |
| title_full_unstemmed | Association between maternal exposure to environmental endocrine disruptors and the risk of congenital heart diseases in offspring: a systematic review and meta-analysis |
| title_short | Association between maternal exposure to environmental endocrine disruptors and the risk of congenital heart diseases in offspring: a systematic review and meta-analysis |
| title_sort | association between maternal exposure to environmental endocrine disruptors and the risk of congenital heart diseases in offspring a systematic review and meta analysis |
| topic | congenital heart diseases environmental endocrine disruptors maternal exposure meta-analysis |
| url | https://doi.org/10.1088/1748-9326/ad21b2 |
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