Profiling of patient-specific myocytes identifies altered gene expression in the ophthalmoplegic subphenotype of myasthenia gravis

Profiling of patient-specific myocytes identifies altered gene expression in the ophthalmoplegic subphenotype of myasthenia gravis

Abstract Background While extraocular muscles are affected early in myasthenia gravis (MG), but respond to treatment, we observe a high incidence of treatment-resistant ophthalmoplegia (OP-MG) among MG subjects with African genetic ancestry. Previously, using whole exome sequencing, we reported pote...

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Bibliographic Details
Main Authors: Melissa Nel, Sharon Prince, Jeannine M. Heckmann
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Myasthenia gravis
Ophthalmoplegia
Gene expression
Transdifferentiation
Subphenotype
Myotranscriptome
Online Access:http://link.springer.com/article/10.1186/s13023-019-1003-y

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