DNMT3A Mutation-Induced CDK1 Overexpression Promotes Leukemogenesis by Modulating the Interaction between EZH2 and DNMT3A

DNMT3A Mutation-Induced CDK1 Overexpression Promotes Leukemogenesis by Modulating the Interaction between EZH2 and DNMT3A

<i>DNMT3A</i> mutations are frequently identified in acute myeloid leukemia (AML) and indicate poor prognosis. Previously, we found that the hotspot mutation DNMT3A R882H could upregulate CDK1 and induce AML in conditional knock-in mice. However, the mechanism by which CDK1 is involved i...

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Bibliographic Details
Main Authors: Ying Yang, Yujun Dai, Xuejiao Yang, Songfang Wu, Yueying Wang
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomolecules
Subjects:
acute myeloid leukemia
DNA methyltransferase 3A
mutation
CDK1
targeted therapy
Online Access:https://www.mdpi.com/2218-273X/11/6/781

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