Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers
Active enhancers are still understudied in colorectal cancers (CRC). Here the authors analyse active enhancers in CRC patients using genomics, transcriptomics, and epigenomics, identifying and validating variant super-enhancer loci as well as KLF3 as a relevant transcription factor.
Bibliographic Details
| Main Authors: |
Qing-Lan Li,
Xiang Lin,
Ya-Li Yu,
Lin Chen,
Qi-Xin Hu,
Meng Chen,
Nan Cao,
Chen Zhao,
Chen-Yu Wang,
Cheng-Wei Huang,
Lian-Yun Li,
Mei Ye,
Min Wu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-26600-5
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