Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers
Active enhancers are still understudied in colorectal cancers (CRC). Here the authors analyse active enhancers in CRC patients using genomics, transcriptomics, and epigenomics, identifying and validating variant super-enhancer loci as well as KLF3 as a relevant transcription factor.
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26600-5 |
| _version_ | 1819199794983206912 |
|---|---|
| author | Qing-Lan Li Xiang Lin Ya-Li Yu Lin Chen Qi-Xin Hu Meng Chen Nan Cao Chen Zhao Chen-Yu Wang Cheng-Wei Huang Lian-Yun Li Mei Ye Min Wu |
| author_facet | Qing-Lan Li Xiang Lin Ya-Li Yu Lin Chen Qi-Xin Hu Meng Chen Nan Cao Chen Zhao Chen-Yu Wang Cheng-Wei Huang Lian-Yun Li Mei Ye Min Wu |
| author_sort | Qing-Lan Li |
| collection | DOAJ |
| description | Active enhancers are still understudied in colorectal cancers (CRC). Here the authors analyse active enhancers in CRC patients using genomics, transcriptomics, and epigenomics, identifying and validating variant super-enhancer loci as well as KLF3 as a relevant transcription factor. |
| first_indexed | 2024-12-23T03:22:00Z |
| format | Article |
| id | doaj.art-674cf176220842dd92978ff6bc45defa |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T03:22:00Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-674cf176220842dd92978ff6bc45defa2022-12-21T18:01:59ZengNature PortfolioNature Communications2041-17232021-11-0112111110.1038/s41467-021-26600-5Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancersQing-Lan Li0Xiang Lin1Ya-Li Yu2Lin Chen3Qi-Xin Hu4Meng Chen5Nan Cao6Chen Zhao7Chen-Yu Wang8Cheng-Wei Huang9Lian-Yun Li10Mei Ye11Min Wu12Frontier Science Center for Immunology and Metabolism, RNA Institute, Hubei Key Laboratory of Cell Homeostasis, Hubei Key Laboratory of Developmentally Originated Disease, Hubei Key Laboratory of Intestinal and Colorectal Diseases, College of Life Sciences, Wuhan UniversityFrontier Science Center for Immunology and Metabolism, RNA Institute, Hubei Key Laboratory of Cell Homeostasis, Hubei Key Laboratory of Developmentally Originated Disease, Hubei Key Laboratory of Intestinal and Colorectal Diseases, College of Life Sciences, Wuhan UniversityDivision of Gastroenterology, Department of Geriatrics, Hubei Clinical Centre & Key Laboratory of Intestinal and Colorectal Diseases, Zhongnan Hospital, Wuhan UniversityFrontier Science Center for Immunology and Metabolism, RNA Institute, Hubei Key Laboratory of Cell Homeostasis, Hubei Key Laboratory of Developmentally Originated Disease, Hubei Key Laboratory of Intestinal and Colorectal Diseases, College of Life Sciences, Wuhan UniversityFrontier Science Center for Immunology and Metabolism, RNA Institute, Hubei Key Laboratory of Cell Homeostasis, Hubei Key Laboratory of Developmentally Originated Disease, Hubei Key Laboratory of Intestinal and Colorectal Diseases, College of Life Sciences, Wuhan UniversityDivision of Gastroenterology, Department of Geriatrics, Hubei Clinical Centre & Key Laboratory of Intestinal and Colorectal Diseases, Zhongnan Hospital, Wuhan UniversityDivision of Gastroenterology, Department of Geriatrics, Hubei Clinical Centre & Key Laboratory of Intestinal and Colorectal Diseases, Zhongnan Hospital, Wuhan UniversityFrontier Science Center for Immunology and Metabolism, RNA Institute, Hubei Key Laboratory of Cell Homeostasis, Hubei Key Laboratory of Developmentally Originated Disease, Hubei Key Laboratory of Intestinal and Colorectal Diseases, College of Life Sciences, Wuhan UniversityFrontier Science Center for Immunology and Metabolism, RNA Institute, Hubei Key Laboratory of Cell Homeostasis, Hubei Key Laboratory of Developmentally Originated Disease, Hubei Key Laboratory of Intestinal and Colorectal Diseases, College of Life Sciences, Wuhan UniversityFrontier Science Center for Immunology and Metabolism, RNA Institute, Hubei Key Laboratory of Cell Homeostasis, Hubei Key Laboratory of Developmentally Originated Disease, Hubei Key Laboratory of Intestinal and Colorectal Diseases, College of Life Sciences, Wuhan UniversityFrontier Science Center for Immunology and Metabolism, RNA Institute, Hubei Key Laboratory of Cell Homeostasis, Hubei Key Laboratory of Developmentally Originated Disease, Hubei Key Laboratory of Intestinal and Colorectal Diseases, College of Life Sciences, Wuhan UniversityDivision of Gastroenterology, Department of Geriatrics, Hubei Clinical Centre & Key Laboratory of Intestinal and Colorectal Diseases, Zhongnan Hospital, Wuhan UniversityFrontier Science Center for Immunology and Metabolism, RNA Institute, Hubei Key Laboratory of Cell Homeostasis, Hubei Key Laboratory of Developmentally Originated Disease, Hubei Key Laboratory of Intestinal and Colorectal Diseases, College of Life Sciences, Wuhan UniversityActive enhancers are still understudied in colorectal cancers (CRC). Here the authors analyse active enhancers in CRC patients using genomics, transcriptomics, and epigenomics, identifying and validating variant super-enhancer loci as well as KLF3 as a relevant transcription factor.https://doi.org/10.1038/s41467-021-26600-5 |
| spellingShingle | Qing-Lan Li Xiang Lin Ya-Li Yu Lin Chen Qi-Xin Hu Meng Chen Nan Cao Chen Zhao Chen-Yu Wang Cheng-Wei Huang Lian-Yun Li Mei Ye Min Wu Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers Nature Communications |
| title | Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers |
| title_full | Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers |
| title_fullStr | Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers |
| title_full_unstemmed | Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers |
| title_short | Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers |
| title_sort | genome wide profiling in colorectal cancer identifies phf19 and tbc1d16 as oncogenic super enhancers |
| url | https://doi.org/10.1038/s41467-021-26600-5 |
| work_keys_str_mv | AT qinglanli genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers AT xianglin genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers AT yaliyu genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers AT linchen genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers AT qixinhu genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers AT mengchen genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers AT nancao genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers AT chenzhao genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers AT chenyuwang genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers AT chengweihuang genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers AT lianyunli genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers AT meiye genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers AT minwu genomewideprofilingincolorectalcanceridentifiesphf19andtbc1d16asoncogenicsuperenhancers |