Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease
Nan Ji,1,2,* Zhongwen Qi,1,* Yueyao Wang,1 Xiaoya Yang,1 Zhipeng Yan,1 Meng Li,1 Qihui Ge,1 Junping Zhang1 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300183, People’s Republic of China; 2National Clinical Research Center for Chinese Medicine Ac...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-06-01
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| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/pyroptosis-a-new-regulating-mechanism-in-cardiovascular-disease-peer-reviewed-fulltext-article-JIR |
| _version_ | 1818718693064966144 |
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| author | Ji N Qi Z Wang Y Yang X Yan Z Li M Ge Q Zhang J |
| author_facet | Ji N Qi Z Wang Y Yang X Yan Z Li M Ge Q Zhang J |
| author_sort | Ji N |
| collection | DOAJ |
| description | Nan Ji,1,2,* Zhongwen Qi,1,* Yueyao Wang,1 Xiaoya Yang,1 Zhipeng Yan,1 Meng Li,1 Qihui Ge,1 Junping Zhang1 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300183, People’s Republic of China; 2National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300193, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junping Zhang Email tjzhtcm@163.comAbstract: Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and apoptosis, pyroptosis has unique characteristics in morphology and mechanism. Specifically, pyroptosis is a kind of cell lysis mediated by the Gasdermin family, releases inflammatory cytokines IL-1β and IL-18. There are three different forms of mechanism, which are caspase-1-mediated, caspase-4/5/11-mediated and caspase-3-mediated. A large number of studies have proved that pyroptosis is closely related to cardiovascular disease. This paper reviewed the recent progress in the related research on pyroptosis and myocardial infarction, ischemia-reperfusion, atherosclerosis, diabetic cardiomyopathy, arrhythmia, heart failure hypertension and Kawasaki disease. Therefore, we believe that pyroptosis may be a new therapeutic target in the cardiovascular field.Keywords: pyroptosis, cardiopathy, NLRP3, caspase-1, IL-1β |
| first_indexed | 2024-12-17T19:55:06Z |
| format | Article |
| id | doaj.art-674f6b8743ae427b859a77a8a5c3ce3d |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-12-17T19:55:06Z |
| publishDate | 2021-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-674f6b8743ae427b859a77a8a5c3ce3d2022-12-21T21:34:37ZengDove Medical PressJournal of Inflammation Research1178-70312021-06-01Volume 142647266666135Pyroptosis: A New Regulating Mechanism in Cardiovascular DiseaseJi NQi ZWang YYang XYan ZLi MGe QZhang JNan Ji,1,2,* Zhongwen Qi,1,* Yueyao Wang,1 Xiaoya Yang,1 Zhipeng Yan,1 Meng Li,1 Qihui Ge,1 Junping Zhang1 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300183, People’s Republic of China; 2National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300193, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junping Zhang Email tjzhtcm@163.comAbstract: Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and apoptosis, pyroptosis has unique characteristics in morphology and mechanism. Specifically, pyroptosis is a kind of cell lysis mediated by the Gasdermin family, releases inflammatory cytokines IL-1β and IL-18. There are three different forms of mechanism, which are caspase-1-mediated, caspase-4/5/11-mediated and caspase-3-mediated. A large number of studies have proved that pyroptosis is closely related to cardiovascular disease. This paper reviewed the recent progress in the related research on pyroptosis and myocardial infarction, ischemia-reperfusion, atherosclerosis, diabetic cardiomyopathy, arrhythmia, heart failure hypertension and Kawasaki disease. Therefore, we believe that pyroptosis may be a new therapeutic target in the cardiovascular field.Keywords: pyroptosis, cardiopathy, NLRP3, caspase-1, IL-1βhttps://www.dovepress.com/pyroptosis-a-new-regulating-mechanism-in-cardiovascular-disease-peer-reviewed-fulltext-article-JIRpyroptosiscardiopathynlrp3caspase-1il-1β |
| spellingShingle | Ji N Qi Z Wang Y Yang X Yan Z Li M Ge Q Zhang J Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease Journal of Inflammation Research pyroptosis cardiopathy nlrp3 caspase-1 il-1β |
| title | Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
| title_full | Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
| title_fullStr | Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
| title_full_unstemmed | Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
| title_short | Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
| title_sort | pyroptosis a new regulating mechanism in cardiovascular disease |
| topic | pyroptosis cardiopathy nlrp3 caspase-1 il-1β |
| url | https://www.dovepress.com/pyroptosis-a-new-regulating-mechanism-in-cardiovascular-disease-peer-reviewed-fulltext-article-JIR |
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