Studying the Impact of Persistent Organic Pollutants Exposure on Human Health by Proteomic Analysis: A Systematic Review
Persistent organic pollutants (POPs) are organic chemical substances that are widely distributed in environments around the globe. POPs accumulate in living organisms and are found at high concentrations in the food chain. Humans are thus continuously exposed to these chemical substances, in which t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/14271 |
| _version_ | 1797465029418680320 |
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| author | Sophie Guillotin Nicolas Delcourt |
| author_facet | Sophie Guillotin Nicolas Delcourt |
| author_sort | Sophie Guillotin |
| collection | DOAJ |
| description | Persistent organic pollutants (POPs) are organic chemical substances that are widely distributed in environments around the globe. POPs accumulate in living organisms and are found at high concentrations in the food chain. Humans are thus continuously exposed to these chemical substances, in which they exert hepatic, reproductive, developmental, behavioral, neurologic, endocrine, cardiovascular, and immunologic adverse health effects. However, considerable information is unknown regarding the mechanism by which POPs exert their adverse effects in humans, as well as the molecular and cellular responses involved. Data are notably lacking concerning the consequences of acute and chronic POP exposure on changes in gene expression, protein profile, and metabolic pathways. We conducted a systematic review to provide a synthesis of knowledge of POPs arising from proteomics-based research. The data source used for this review was PubMed. This study was carried out following the PRISMA guidelines. Of the 742 items originally identified, 89 were considered in the review. This review presents a comprehensive overview of the most recent research and available solutions to explore proteomics datasets to identify new features relevant to human health. Future perspectives in proteomics studies are discussed. |
| first_indexed | 2024-03-09T18:16:39Z |
| format | Article |
| id | doaj.art-674f8db6ae444d89b1fea0f9752b30e3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:16:39Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-674f8db6ae444d89b1fea0f9752b30e32023-11-24T08:41:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221427110.3390/ijms232214271Studying the Impact of Persistent Organic Pollutants Exposure on Human Health by Proteomic Analysis: A Systematic ReviewSophie Guillotin0Nicolas Delcourt1Poison Control Centre, Toulouse University Hospital, 31059 Toulouse, FrancePoison Control Centre, Toulouse University Hospital, 31059 Toulouse, FrancePersistent organic pollutants (POPs) are organic chemical substances that are widely distributed in environments around the globe. POPs accumulate in living organisms and are found at high concentrations in the food chain. Humans are thus continuously exposed to these chemical substances, in which they exert hepatic, reproductive, developmental, behavioral, neurologic, endocrine, cardiovascular, and immunologic adverse health effects. However, considerable information is unknown regarding the mechanism by which POPs exert their adverse effects in humans, as well as the molecular and cellular responses involved. Data are notably lacking concerning the consequences of acute and chronic POP exposure on changes in gene expression, protein profile, and metabolic pathways. We conducted a systematic review to provide a synthesis of knowledge of POPs arising from proteomics-based research. The data source used for this review was PubMed. This study was carried out following the PRISMA guidelines. Of the 742 items originally identified, 89 were considered in the review. This review presents a comprehensive overview of the most recent research and available solutions to explore proteomics datasets to identify new features relevant to human health. Future perspectives in proteomics studies are discussed.https://www.mdpi.com/1422-0067/23/22/14271persistent organic pollutantproteomicshepatotoxicityreprotoxicitydevelopmental toxicityneurotoxicity |
| spellingShingle | Sophie Guillotin Nicolas Delcourt Studying the Impact of Persistent Organic Pollutants Exposure on Human Health by Proteomic Analysis: A Systematic Review International Journal of Molecular Sciences persistent organic pollutant proteomics hepatotoxicity reprotoxicity developmental toxicity neurotoxicity |
| title | Studying the Impact of Persistent Organic Pollutants Exposure on Human Health by Proteomic Analysis: A Systematic Review |
| title_full | Studying the Impact of Persistent Organic Pollutants Exposure on Human Health by Proteomic Analysis: A Systematic Review |
| title_fullStr | Studying the Impact of Persistent Organic Pollutants Exposure on Human Health by Proteomic Analysis: A Systematic Review |
| title_full_unstemmed | Studying the Impact of Persistent Organic Pollutants Exposure on Human Health by Proteomic Analysis: A Systematic Review |
| title_short | Studying the Impact of Persistent Organic Pollutants Exposure on Human Health by Proteomic Analysis: A Systematic Review |
| title_sort | studying the impact of persistent organic pollutants exposure on human health by proteomic analysis a systematic review |
| topic | persistent organic pollutant proteomics hepatotoxicity reprotoxicity developmental toxicity neurotoxicity |
| url | https://www.mdpi.com/1422-0067/23/22/14271 |
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