Spinal meningiomas, from biology to management - A literature review
Meningiomas arise from arachnoidal cap cells of the meninges, constituting the most common type of central nervous system tumors, and are considered benign tumors in most cases. Their incidence increases with age, and they mainly affect females, constituting 25-46% of primary spinal tumors. Spinal m...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1084404/full |
| _version_ | 1828065266639044608 |
|---|---|
| author | Nicolas Serratrice Imène Lameche Christian Attieh Moussa A Chalah Moussa A Chalah Moussa A Chalah Joe Faddoul Joe Faddoul Bilal Tarabay Rabih Bou-Nassif Youssef Ali Joseph G Mattar François Nataf Samar S Ayache Samar S Ayache Samar S Ayache Samar S Ayache Georges N Abi Lahoud Georges N Abi Lahoud |
| author_facet | Nicolas Serratrice Imène Lameche Christian Attieh Moussa A Chalah Moussa A Chalah Moussa A Chalah Joe Faddoul Joe Faddoul Bilal Tarabay Rabih Bou-Nassif Youssef Ali Joseph G Mattar François Nataf Samar S Ayache Samar S Ayache Samar S Ayache Samar S Ayache Georges N Abi Lahoud Georges N Abi Lahoud |
| author_sort | Nicolas Serratrice |
| collection | DOAJ |
| description | Meningiomas arise from arachnoidal cap cells of the meninges, constituting the most common type of central nervous system tumors, and are considered benign tumors in most cases. Their incidence increases with age, and they mainly affect females, constituting 25-46% of primary spinal tumors. Spinal meningiomas could be detected incidentally or be unraveled by various neurological symptoms (e.g., back pain, sphincter dysfunction, sensorimotor deficits). The gold standard diagnostic modality for spinal meningiomas is Magnetic resonance imaging (MRI) which permits their classification into four categories based on their radiological appearance. According to the World Health Organization (WHO) classification, the majority of spinal meningiomas are grade 1. Nevertheless, they can be of higher grade (grades 2 and 3) with atypical or malignant histology and a more aggressive course. To date, surgery is the best treatment where the big majority of meningiomas can be cured. Advances in surgical techniques (ultrasonic dissection, microsurgery, intraoperative monitoring) increase the complete resection rate. Operated patients have a satisfactory prognosis, even in those with poor preoperative neurological status. Adjuvant therapy has a growing role in treating spinal meningiomas, mainly in the case of subtotal resection and tumor recurrence. The current paper reviews the fundamental epidemiological and clinical aspects of spinal meningiomas, their histological and genetic characteristics, and their management, including the various surgical novelties and techniques. |
| first_indexed | 2024-04-10T23:12:16Z |
| format | Article |
| id | doaj.art-67505e2850bc4155b5a5a59ca151ddef |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T23:12:16Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-67505e2850bc4155b5a5a59ca151ddef2023-01-13T04:37:52ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.10844041084404Spinal meningiomas, from biology to management - A literature reviewNicolas Serratrice0Imène Lameche1Christian Attieh2Moussa A Chalah3Moussa A Chalah4Moussa A Chalah5Joe Faddoul6Joe Faddoul7Bilal Tarabay8Rabih Bou-Nassif9Youssef Ali10Joseph G Mattar11François Nataf12Samar S Ayache13Samar S Ayache14Samar S Ayache15Samar S Ayache16Georges N Abi Lahoud17Georges N Abi Lahoud18Institut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico-Chirurgical Bizet, Paris, FranceInstitut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico-Chirurgical Bizet, Paris, FranceInstitut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico-Chirurgical Bizet, Paris, FranceInstitut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico-Chirurgical Bizet, Paris, FranceEA 4391, Excitabilité Nerveuse et Thérapeutique, Faculté de Santé, Université Paris Est, Créteil, FranceGilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, LebanonInstitut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico-Chirurgical Bizet, Paris, FranceService de Neurochirurgie, Centre Hospitalier de la Côte Basque, Bayonne, FranceInstitut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico-Chirurgical Bizet, Paris, FranceDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesInstitut de Chirurgie Osseuse et de Neurochirurgie, Médipole-Montagard, Avignon, FranceInstitut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico-Chirurgical Bizet, Paris, FranceService de Neurochirurgie, Hôpital Lariboisière, Paris, FranceInstitut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico-Chirurgical Bizet, Paris, FranceEA 4391, Excitabilité Nerveuse et Thérapeutique, Faculté de Santé, Université Paris Est, Créteil, FranceGilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, LebanonService de Physiologie-Explorations Fonctionnelles, DMU FIxIT, Hôpital Henri Mondor, Créteil, FranceInstitut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico-Chirurgical Bizet, Paris, FranceGilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, LebanonMeningiomas arise from arachnoidal cap cells of the meninges, constituting the most common type of central nervous system tumors, and are considered benign tumors in most cases. Their incidence increases with age, and they mainly affect females, constituting 25-46% of primary spinal tumors. Spinal meningiomas could be detected incidentally or be unraveled by various neurological symptoms (e.g., back pain, sphincter dysfunction, sensorimotor deficits). The gold standard diagnostic modality for spinal meningiomas is Magnetic resonance imaging (MRI) which permits their classification into four categories based on their radiological appearance. According to the World Health Organization (WHO) classification, the majority of spinal meningiomas are grade 1. Nevertheless, they can be of higher grade (grades 2 and 3) with atypical or malignant histology and a more aggressive course. To date, surgery is the best treatment where the big majority of meningiomas can be cured. Advances in surgical techniques (ultrasonic dissection, microsurgery, intraoperative monitoring) increase the complete resection rate. Operated patients have a satisfactory prognosis, even in those with poor preoperative neurological status. Adjuvant therapy has a growing role in treating spinal meningiomas, mainly in the case of subtotal resection and tumor recurrence. The current paper reviews the fundamental epidemiological and clinical aspects of spinal meningiomas, their histological and genetic characteristics, and their management, including the various surgical novelties and techniques.https://www.frontiersin.org/articles/10.3389/fonc.2022.1084404/fullgross total resection (GTR)meningiomasspinal meningiomasstereotactic body radiation therapy (SBRT)minimally invasive (MIS)microsurgery (MS) |
| spellingShingle | Nicolas Serratrice Imène Lameche Christian Attieh Moussa A Chalah Moussa A Chalah Moussa A Chalah Joe Faddoul Joe Faddoul Bilal Tarabay Rabih Bou-Nassif Youssef Ali Joseph G Mattar François Nataf Samar S Ayache Samar S Ayache Samar S Ayache Samar S Ayache Georges N Abi Lahoud Georges N Abi Lahoud Spinal meningiomas, from biology to management - A literature review Frontiers in Oncology gross total resection (GTR) meningiomas spinal meningiomas stereotactic body radiation therapy (SBRT) minimally invasive (MIS) microsurgery (MS) |
| title | Spinal meningiomas, from biology to management - A literature review |
| title_full | Spinal meningiomas, from biology to management - A literature review |
| title_fullStr | Spinal meningiomas, from biology to management - A literature review |
| title_full_unstemmed | Spinal meningiomas, from biology to management - A literature review |
| title_short | Spinal meningiomas, from biology to management - A literature review |
| title_sort | spinal meningiomas from biology to management a literature review |
| topic | gross total resection (GTR) meningiomas spinal meningiomas stereotactic body radiation therapy (SBRT) minimally invasive (MIS) microsurgery (MS) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1084404/full |
| work_keys_str_mv | AT nicolasserratrice spinalmeningiomasfrombiologytomanagementaliteraturereview AT imenelameche spinalmeningiomasfrombiologytomanagementaliteraturereview AT christianattieh spinalmeningiomasfrombiologytomanagementaliteraturereview AT moussaachalah spinalmeningiomasfrombiologytomanagementaliteraturereview AT moussaachalah spinalmeningiomasfrombiologytomanagementaliteraturereview AT moussaachalah spinalmeningiomasfrombiologytomanagementaliteraturereview AT joefaddoul spinalmeningiomasfrombiologytomanagementaliteraturereview AT joefaddoul spinalmeningiomasfrombiologytomanagementaliteraturereview AT bilaltarabay spinalmeningiomasfrombiologytomanagementaliteraturereview AT rabihbounassif spinalmeningiomasfrombiologytomanagementaliteraturereview AT youssefali spinalmeningiomasfrombiologytomanagementaliteraturereview AT josephgmattar spinalmeningiomasfrombiologytomanagementaliteraturereview AT francoisnataf spinalmeningiomasfrombiologytomanagementaliteraturereview AT samarsayache spinalmeningiomasfrombiologytomanagementaliteraturereview AT samarsayache spinalmeningiomasfrombiologytomanagementaliteraturereview AT samarsayache spinalmeningiomasfrombiologytomanagementaliteraturereview AT samarsayache spinalmeningiomasfrombiologytomanagementaliteraturereview AT georgesnabilahoud spinalmeningiomasfrombiologytomanagementaliteraturereview AT georgesnabilahoud spinalmeningiomasfrombiologytomanagementaliteraturereview |