Correlation between changes of arterial stiffness parameters and neurological functional improvement in patients with acute cerebral infarction
Objective To investigate the relationship between the changes of arterial stiffness parameters and neurological functional improvement in patients with acute cerebral infarction. Methods According to clinical prognosis， 107 patients with acute cerebral infarction were divided into the discharge grou...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of New Medicine
2023-07-01
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| Series: | Xin yixue |
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| Online Access: | https://www.xinyixue.cn/fileup/0253-9802/PDF/1691564044928-1944695782.pdf |
| Summary: | Objective To investigate the relationship between the changes of arterial stiffness parameters and neurological functional improvement in patients with acute cerebral infarction. Methods According to clinical prognosis， 107 patients with acute cerebral infarction were divided into the discharge group （n = 90） and in-hospital mortality group （n = 17）. Patients in the discharge group were further divided into functional improvement group （n = 51） and non-functional improvement group （n = 39）. On the 1st and 7th d after admission， 24-h non-invasive blood pressure was monitored and arterial stiffness parameters including arterial stiffness index （ASI） and pulse wave velocity （PWV） were measured. The severity of cerebral infarction was determined by National Institutes of Health Stroke Scale （NIHSS）. The recovery of neurological function was evaluated by modified Rankin scale （mRS）. The independent predictors of in-hospital mortality and neurological functional improvement were identified by Logistic regression analysis. Results NIHSS score， ASI and PWV upon admission of patients in the in-hospital mortality group were significantly higher than those in the discharge group （all P < 0.05）. Logistic regression analysis found that NIHSS score upon admission and ASI were the independent predictors of in-hospital mortality. In the neurological functional improvement group， the PWV measured on the 7th d was significantly lower than that measured on the 1st d （P < 0.05）. There were significant differences in PWV measured on the 1st and 7th d between patients with and without neurological functional improvement （both P < 0.05）. Decline in PWV and central diastolic blood pressure （CDBP） were the independent predictors of neurological functional improvement （both P < 0.05）. Conclusions Increased ASI is associated with higher in-hospital mortality in patients with acute cerebral infarction. Additionally， PWV decline is correlated with neurological functional improvement in patients with acute cerebral infarction during hospitalization. |
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| ISSN: | 0253-9802 |