Fast HPLC-based affinity method to determine capsid titer and full/empty ratio of adeno-associated viral vectors

Fast HPLC-based affinity method to determine capsid titer and full/empty ratio of adeno-associated viral vectors

Recombinant adeno-associated viruses (rAAVs) are promising gene delivery vectors in the emerging field of in vivo gene therapies. To ensure their consistent quality during manufacturing and process development, multiple analytical techniques have been proposed for the characterization and quantifica...

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Bibliographic Details
Main Authors: Jakob Heckel, Andres Martinez, Carsten Elger, Markus Haindl, Michael Leiss, Raphael Ruppert, Chris Williams, Jürgen Hubbuch, Tobias Graf
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
high-throughput
gene therapy
adeno-associated
affinity chromatography
fluorescence
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123001870

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