The <i>TREM2</i> H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release

The <i>TREM2</i> H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release

Previously, we reported that H157Y, a rare coding variant on exon 3 of the triggering receptor expressed on myeloid cells 2 gene (<i>TREM2</i>), was associated with Alzheimer’s disease (AD) risk in a Han Chinese population. To date, how this variant increases AD risk has remained unclear...

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Bibliographic Details
Main Authors: Xin-Xin Fu, Shuai-Yu Chen, Hui-Wen Lian, Yang Deng, Rui Duan, Ying-Dong Zhang, Teng Jiang
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Brain Sciences
Subjects:
Alzheimer’s disease
<i>TREM2</i>
H157Y variant
amyloid-β
CRISPR-Cas9
microglia
Online Access:https://www.mdpi.com/2076-3425/13/4/642

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